权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

NMR instrumentation: Stanford core facility 800 MHz console

NMR 仪器：斯坦福核心设施 800 MHz 控制台

基本信息

批准号：
7790418
负责人：
JOSEPH D PUGLISI
金额：
$ 44.61万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-16 至 2011-12-15
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The Stanford Magnetic Resonance Laboratory SMRL) is a research core facility in the Stanford University School of Medicine, providing high-field NMR instrumentation and expertise to the Stanford research community. The SMRL seeks a new console for the aging Varian Inova 800 MHz spectrometer in order to best support high-field research. The 11 year old 800 spectrometer was purchased in 1998 by Stanford with University funds to stimulate high field spectroscopy. Then, it was one of the first four produced by Varian (console) and Oxford (magnet) in the world. It has served well for the past decade-plus supporting a plethora of NIH-funded research projects. The magnet continues to function well, but the console is showing its age with increased electronic component instabilities and downtimes. By leveraging an existing 800 MHz magnet in an established facility, upgrading the spectrometer console will provide immediate benefits to the high-field user base at a quarter to a third the cost of a entirely new 800 MHz spectrometer system and without need for any new infrastructure improvements. The new console will immediately provide state-of-the-art technology to the challenging projects of the high-field NIH-funded user base at the SMRL (Axel Brunger, Ronald Davis, K. Christopher Garcia, Daniel Herschlag, Brian Kobilka, Roger Kornberg, Merritt Maduke, and Joseph Puglisi). Benefits include highly parallelized architecture, advanced digital filter algorithms, and full digital receiver, enabling the ability to run the most demanding of high- field experiments including advanced support for fast techniques, non-linear sampling methods, and capability for multiple receiver technology. Research efforts from the high-field NMR users range from studying the fundamental workings of the immune system, to seeking a clinical understanding of the physiological contributors to traumatic distress and disease, to utilization of novel model systems of human disease, to screening for new drugs and therapeutics; projects that will all benefit greatly from the shared instrumentation resource to be provided by the NIH.

描述（由申请人提供）：斯坦福大学磁共振实验室（SMRL）是斯坦福大学医学院的研究核心设施，为斯坦福大学研究界提供高场核磁共振仪器和专业知识。SMRL为老化的Varian Inova 800 MHz光谱仪寻找新的控制台，以最好地支持高场研究。1998年，斯坦福大学用大学基金购买了11年历史的800光谱仪，用于激发高场光谱学。当时，它是世界上最早由瓦里安（控制台）和牛津（磁铁）生产的四台之一。在过去的十多年中，它一直很好地支持了大量NIH资助的研究项目。磁铁继续运作良好，但控制台显示其年龄与增加电子元件不稳定和停机时间。通过利用现有设施中现有的800 MHz磁体，升级光谱仪控制台将为高场用户群提供直接利益，其成本是全新800 MHz光谱仪系统的四分之一到三分之一，并且不需要任何新的基础设施改进。新的控制台将立即提供国家的最先进的技术，以具有挑战性的项目的高领域NIH资助的用户群在SMRL（阿克塞尔布伦杰，罗纳德戴维斯，K。Christopher Garcia，丹尼尔赫施拉格，Brian Kobilka，Roger Kornberg，Merritt Maduke，and Joseph Puglisi）.其优势包括高度并行化架构、先进的数字滤波算法和全数字接收器，能够运行最苛刻的高场实验，包括对快速技术、非线性采样方法的先进支持，以及多接收器技术的能力。高场NMR用户的研究工作范围从研究免疫系统的基本工作，到寻求对创伤性痛苦和疾病的生理贡献者的临床理解，到利用人类疾病的新模型系统，到筛选新药和治疗方法;这些项目都将从NIH提供的共享仪器资源中受益匪浅。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1.

DOI：
10.1007/s10858-015-9898-7
发表时间：
2015-04
期刊：
JOURNAL OF BIOMOLECULAR NMR
影响因子：
2.7
作者：
Abraham, Sherwin J.;Cheng, Ricky C.;Chew, Thomas A.;Khantwal, Chandra M.;Liu, Corey W.;Gong, Shimei;Nakamoto, Robert K.;Maduke, Merritt
通讯作者：
Maduke, Merritt

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.