Axiom zeego shared instrument grant

描述（由申请人提供）：该项目的目的是通过升级到西门子Artis zeego，一种安装在机器人上的数字平板c型臂，来改进和扩展Axiom实验室c型臂CT系统的成像能力。该设备将由15个用户共享。总共13个NIH拨款（R01s, R21s, K99， SCRR, P50， STTR）和几个未获资助的项目将通过购买仪器而得到显著加强。硬件技术将大大提高我们的成像能力是西门子Artis zeego系统，目前唯一的同类系统正在出售。本系统的技术优势主要有三个方面：1。6自由度机器人安装c型臂，实现轨迹规格的充分灵活性；2. 超高帧率数字检测器（120fps）；3. 非常快速，非常可重复的旋转和/或预定义轨迹的运动（高达1200/s）。该系统提供了在运动过程中进行实时透视成像、负重高分辨率CT成像、ECG门控心脏成像和足够大的容量覆盖整个人脑的定量灌注的机会。该系统正好位于x射线成像系统中，这是目前任何其他技术都无法覆盖的，因此为研究新问题和开发新的成像方案提供了独特的机会。我们正在从根据平均反应来治疗疾病转变为根据个体患者的具体特征来治疗疾病。成像和图像指导发挥着关键作用，通过结合高分辨率诊断成像、手术内指导和对给定治疗反应的评估，有可能提供有针对性的个性化医疗保健。zeego系统的成像协议和图像引导技术的研究和开发将直接转化为临床，因此该系统也提供了从实验室到床边的重要桥梁。

DESCRIPTION (provided by applicant): The aim of this project is to both improve and expand the imaging capabilities of the Axiom lab C-arm CT system by upgrading to the Siemens Artis zeego, a robot-mounted digital flat panel C-arm. The equipment will be shared by 15 users. A total of 13 NIH grants (R01s, R21s, K99, SCRR, P50, STTR) and several unfunded projects will be significantly enhanced by the instrumentation purchase. The hardware technology that will greatly enhance our imaging capabilities is the Siemens Artis zeego system, currently the only system of its kind being sold. The three main technical advantages of this system are: 1. 6-degrees-of-freedom robot-mounted C-arm, for full flexibility of trajectory specification; 2. very high frame rate digital detector (120 fps); 3. Very fast, very reproducible rotations and/or motions for pre-defined trajectories (up to 1200/s). This system provides the opportunity to do real-time fluoroscopic imaging during motion, weight-bearing high-resolution CT imaging, ECG- gated cardiac imaging, and quantitative perfusion over a volume that is large enough to cover the whole human brain. The system sits squarely in an x-ray imaging regime that is not currently covered by any other technology, and therefore provides a unique opportunity to investigate new questions and develop new imaging protocols. We are moving from treating a disease based on average response to treating the disease based on the individual patient's specific characteristics. Imaging and Image Guidance have key roles to play, with the potential to provide targeted, personalized healthcare by combining high-resolution diagnostic imaging, intra-procedural guidance, and evaluation of response to a given therapy. Research and development of imaging protocols and image guidance techniques on the zeego system will be directly translatable into the clinic, and so the system also provides an important bridge from bench to bedside. PUBLIC HEALTH RELEVANCE: The overall goal of this project is to upgrade the Axiom lab to a Siemens Artis zeego robot-mounted digital flat panel C-arm fluoroscopy and CT imaging system. The system will be used for research in a broad range of areas including weight-bearing high-resolution CT imaging, quantitative perfusion imaging and cardiovascular imaging. The system provides an important bridging diagnostic and image guidance technology that will help move new therapies into the clinic.