Axiom zeego shared instrument grant

描述（由申请人提供）：本项目的目的是通过升级到Siemens Artis zeego（一种机器人安装的数字平板C形臂）来改进和扩展Axiom实验室C形臂CT系统的成像能力。该设备将由15名用户共享。总共有13个NIH赠款（R 01 s，R21 s，K99，SCRR，P50，STTR）和几个未资助的项目将通过购买仪器得到显着增强。西门子Artis zeego系统是目前唯一销售的同类系统，它将极大地增强我们的成像能力。该系统的三个主要技术优势是：1. 6自由度机器人安装C形臂，实现轨迹规格的完全灵活性; 2.极高帧率数字检测器（120 fps）; 3.非常快，非常可重复的旋转和/或运动预定义的轨迹（高达1200/s）。该系统提供了在运动期间进行实时荧光透视成像、承重高分辨率CT成像、ECG门控心脏成像以及在足够大以覆盖整个人脑的体积上进行定量灌注的机会。该系统完全处于目前任何其他技术都未涵盖的X射线成像机制中，因此为研究新问题和开发新成像协议提供了独特的机会。我们正在从根据平均反应治疗疾病转向根据个别患者的具体特征治疗疾病。成像和图像引导具有关键作用，通过结合高分辨率诊断成像、术中引导和对给定治疗的反应评价，有可能提供有针对性的个性化医疗保健。Zeego系统上的成像协议和图像引导技术的研究和开发将直接转化为临床，因此该系统也提供了从台架到床边的重要桥梁。 公共卫生相关性：该项目的总体目标是将Axiom实验室升级为Siemens Artis zeego机器人安装的数字平板C形臂透视和CT成像系统。该系统将用于广泛领域的研究，包括承重高分辨率 CT成像、定量灌注成像和心血管成像。该系统提供了一种重要的桥接诊断和图像引导技术，有助于将新疗法引入临床。

DESCRIPTION (provided by applicant): The aim of this project is to both improve and expand the imaging capabilities of the Axiom lab C-arm CT system by upgrading to the Siemens Artis zeego, a robot-mounted digital flat panel C-arm. The equipment will be shared by 15 users. A total of 13 NIH grants (R01s, R21s, K99, SCRR, P50, STTR) and several unfunded projects will be significantly enhanced by the instrumentation purchase. The hardware technology that will greatly enhance our imaging capabilities is the Siemens Artis zeego system, currently the only system of its kind being sold. The three main technical advantages of this system are: 1. 6-degrees-of-freedom robot-mounted C-arm, for full flexibility of trajectory specification; 2. very high frame rate digital detector (120 fps); 3. Very fast, very reproducible rotations and/or motions for pre-defined trajectories (up to 1200/s). This system provides the opportunity to do real-time fluoroscopic imaging during motion, weight-bearing high-resolution CT imaging, ECG- gated cardiac imaging, and quantitative perfusion over a volume that is large enough to cover the whole human brain. The system sits squarely in an x-ray imaging regime that is not currently covered by any other technology, and therefore provides a unique opportunity to investigate new questions and develop new imaging protocols. We are moving from treating a disease based on average response to treating the disease based on the individual patient's specific characteristics. Imaging and Image Guidance have key roles to play, with the potential to provide targeted, personalized healthcare by combining high-resolution diagnostic imaging, intra-procedural guidance, and evaluation of response to a given therapy. Research and development of imaging protocols and image guidance techniques on the zeego system will be directly translatable into the clinic, and so the system also provides an important bridge from bench to bedside. PUBLIC HEALTH RELEVANCE: The overall goal of this project is to upgrade the Axiom lab to a Siemens Artis zeego robot-mounted digital flat panel C-arm fluoroscopy and CT imaging system. The system will be used for research in a broad range of areas including weight-bearing high-resolution CT imaging, quantitative perfusion imaging and cardiovascular imaging. The system provides an important bridging diagnostic and image guidance technology that will help move new therapies into the clinic.