Multiphoton Laser Scanning Microscope
多光子激光扫描显微镜
基本信息
- 批准号:7792822
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-27 至 2011-05-26
- 项目状态:已结题
- 来源:
- 关键词:AIDS-Associated NephropathyArterial Fatty StreakBiomedical EngineeringCell physiologyCellsEpithelial CellsFluorescenceGenerationsGenesHousingHuman ResourcesImageImmune systemImmunobiologyInstitutionKidneyLasersMaintenanceMedicineMicroscopeMicroscopyNeoplasm MetastasisNeurologyOrganOrthopedic Surgery proceduresResearch PersonnelResource SharingScanningSensorySubarachnoid HemorrhageSupervisionTendon structureTimeTrainingin vivoinstrumentlaboratory facilitymedical schoolsneurosurgeryrepairedsecond harmonictissue preparationtumor
项目摘要
DESCRIPTION (provided by applicant): A multiphoton laser scanning microscope is requested for the use of eight major users at the Mount Sinai School of Medicine. The instrument will be used for multichannel fluorescence and second harmonic generation imaging of a variety of organs and tissue preparations including both ex-vivo and in-vivo observations. The investigators, from the Departments of Gene and Cell Medicine, Immunobiology, Medicine, Neurology, Neurosurgery and Orthopedic Surgery, will study atherosclerotic plaques, HIV-associated nephropathy, tumor metastasis, tendon damage and repair, subarachnoid hemorrhage, vestibular sensory organs, immune system dynamics, and renal epithelial cell function. The instrument will be situated in and managed by the Microscopy Shared Resource Facility, an ongoing and successful institution-wide core which houses other confocal and widefield microscopes and is currently used by personnel from more than 100 Mount Sinai laboratories, The facility's staff of two full time biomedical engineers will provide supervision and training for users of the requested instrument and will be responsible for its maintenance.
描述(由申请人提供):一个多光子激光扫描显微镜被要求在西奈山医学院的八个主要用户使用。该仪器将用于多种器官和组织制备的多通道荧光和二次谐波成像,包括体外和体内观察。来自基因和细胞医学、免疫生物学、医学、神经学、神经外科和骨科的研究人员将研究动脉粥样硬化斑块、艾滋病毒相关肾病、肿瘤转移、肌腱损伤和修复、蛛网膜下腔出血、前庭感觉器官、免疫系统动力学和肾上皮细胞功能。该仪器将位于显微镜共享资源设施内并由其管理,该设施是一个持续和成功的机构范围内的核心,其中包含其他共聚焦和宽视场显微镜,目前由100多个西奈山实验室的人员使用,该设施的两名全职生物医学工程师将为所需仪器的用户提供监督和培训,并负责其维护。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Delayed exercise promotes remodeling in sub-rupture fatigue damaged tendons.
- DOI:10.1002/jor.22856
- 发表时间:2015-06
- 期刊:
- 影响因子:2.8
- 作者:Bell, R.;Boniello, M. R.;Gendron, N. R.;Flatow, E. L.;Andarawis-Puri, N.
- 通讯作者:Andarawis-Puri, N.
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