Parallel Transmit Array for 7T MRI System

7T MRI 系统并行传输阵列

• 批准号: 7793727
• 负责人: Ravinder Reddy
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793727
• 关键词: Arthritis; Biomedical Research; Bone Diseases; Brain imaging; Cancer Detection; Cardiovascular Diseases; Clinical; Development; Diagnosis; Early Diagnosis; Funding; Future; Growth; Human; Imaging technology; Institution; Joints; Laboratories; Magnetic Resonance; Magnetic Resonance Imaging; Masks; Metabolic Diseases; Monitor; Nerve Degeneration; Neurosciences; Noise; Osteoporosis; Pathology; Patients; Pennsylvania; Perfusion; Physiology; Play; Program Research Project Grants; Request for Proposals; Research; Resources; Role; Running; Scanning; Signal Transduction; Spectrum Analysis; Structure; System; Time; Tissues; Universities; Variant; bioimaging; body system; human disease; insight; method development; molecular imaging; neuroimaging; novel; novel strategies; optical imaging; public health relevance; radiofrequency

DESCRIPTION (provided by applicant): During the past two decades, there has been an explosive growth in the utilization of magnetic resonance imaging (MRI) in biomedical research, such that MRI currently plays a significant role for the diagnosis and management of patients involving virtually every pathology. Since the MR image quality per unit scan time is largely determined by the intrinsic signal-to-noise ratio, several leading institutions in the US and overseas either already have 7T whole-body systems or are on their way to acquiring ultrahigh- field scanners in the near future. Initial results from a few laboratories suggest MRI and MRS at field strengths of 7-9T to have great promise by providing insight into structure, function and physiology in humans not obtainable at lower fields. However, it is well known that at these field strengths, radiofrequency field (RF) in the tissue is highly inhomogeneous which results in spatially dependent tissue contrast and thus masks subtle changes in the contrast due to pathological changes in the tissue. Despite many advantages of ultra high field MRI, the above-mentioned spatial variation of RF field severely limits our ability to exploit the high field advantages to fullest extent. It has been shown that parallel transmit arrays enable one to largely overcome these problems. In this proposal, we request funds for the acquisition of a parallel transmit array for interfacing with 7T whole-body MRI scanner at the University of Pennsylvania. We show that the proposed upgrade of the system will substantially enhance ongoing research in 23 R01s, one P41 and three program project grants at four centers: the Center for Magnetic Resonance and Optical Imaging (CMROI), the Center for Functional Neuroimaging (CfN), the Center for Molecular imaging (CEMI), and the Laboratory for Structural NMR Imaging (LSNI). Biomedical imaging research in these four laboratories covers a wide range of applications and new methods development involving functional brain imaging for basic and clinical neuroscience, the study of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease and tissue perfusion, and joint and bone disease (arthritis and osteoporosis). The 7T system is integrated into the Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS) at the University of Pennsylvania. The resource will be run by an Executive Committee (EC) under the auspices of the current CAMRIS Committee. PUBLIC HEALTH RELEVANCE: Imaging technologies developed at the 7T resource will have substantial impact on fundamental understanding, early diagnosis, and development of novel therapies for several human diseases.

描述（由申请人提供）：在过去的二十年中，磁共振成像（MRI）在生物医学研究中的应用呈爆炸性增长，因此MRI目前在涉及几乎所有病理的患者的诊断和管理中发挥着重要作用。由于每单位扫描时间的MR图像质量在很大程度上取决于固有信噪比，因此美国和海外的几家领先机构要么已经拥有7 T全身系统，要么正在采购近场扫描仪。一些实验室的初步结果表明，在7- 9 T场强下的MRI和MRS具有很大的前景，可以提供在较低场强下无法获得的对人体结构、功能和生理学的洞察。然而，众所周知，在这些场强下，组织中的射频场（RF）是高度不均匀的，这导致空间依赖的组织对比度，从而掩盖了由于组织中的病理变化而导致的对比度的细微变化。尽管超高场MRI具有许多优点，但RF场的上述空间变化严重限制了我们最大程度地利用高场优势的能力。已经表明，并行发射阵列使人们能够在很大程度上克服这些问题。在本提案中，我们请求资金用于购买并行发射阵列，用于与宾夕法尼亚大学的7 T全身MRI扫描仪接口。我们表明，拟议的系统升级将大大提高正在进行的研究在23 R 01，一个P41和三个程序项目赠款在四个中心：中心磁共振和光学成像（CMROI），中心功能神经成像（CfN），中心分子成像（CEMI），和实验室结构核磁共振成像（LSNI）。这四个实验室的生物医学成像研究涵盖了广泛的应用和新方法开发，涉及基础和临床神经科学的功能性脑成像，神经退行性疾病和代谢紊乱的研究，癌症检测和治疗监测的分子成像，心血管疾病和组织灌注的新方法，以及关节和骨骼疾病（关节炎和骨质疏松症）。7 T系统集成到宾夕法尼亚大学高级磁共振成像和光谱学中心（CAMRIS）。该资源将由一个执行委员会在目前的环境管理信息系统委员会的主持下管理。 公共卫生关系：7 T资源开发的成像技术将对几种人类疾病的基本理解、早期诊断和新疗法的开发产生重大影响。