Acquisition of Rigaku MicroMax-007 HF lab x-ray system

购买 Rigaku MicroMax-007 HF 实验室 X 射线系统

• 批准号: 7794221
• 负责人: EATON E LATTMAN
• 金额: $ 49.77万
• 依托单位: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2011-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794221
• 关键词: Anodes; Data Collection; Disease; Drug Design; Equipment; Failure; Funding; Housing; Image; Institutes; Life; Medical Research; Organism; Pharmaceutical Preparations; Process; Proteins; Research Institute; Robotics; Roentgen Rays; Saturn; Site; System; Time; Work; detector

DESCRIPTION (provided by applicant): The Hauptman-Woodward Medical Research Institute seeks to replace an obsolete Rigaku RU- 200 rotating anode x-ray generator with another rotating anode, the Rigaku MicroMax-007 microfocus unit. With the Micromax we are also requesting a Rigaku Saturn 944+ CCD detector and related equipment, the whole comprising a complete X-ray data collection system. The RU-200 was purchased in 1992, and Rigaku has announced that the machine will no longer be supported. Irreversible failure could happen at any time, and the need for replacement is urgent. The Institute currently houses two image plate detectors, one a MAR 345 unit on loan from Stanford and the other our workhorse, an R AXIS IV sited on a RU-H3RHB generator. The MAR unit is dedicated to a collaborative project with Stanford on robotic crystal mounting, and is rarely available for normal data collection. There are 11 NIH-funded projects - plus a slew of more preliminary ones - seeking time on the R AXIS IV, and the queue is often discouragingly long. We feel that the need for a second general purpose data collection system is compelling. HEALTH RELEVANCE: Protein molecules carry out most of the functions in living organisms, and many drugs work by targeting proteins involved in a disease process. The requested equipment will allow us to create three-dimensional images of various protein molecules. These images greatly expedite and refine the process of designing drugs by letting us tailor the drug to its complementary site in the protein.

描述（由申请人提供）：Hauptman-Woodward医学研究所寻求用另一个旋转阳极Rigaku MicroMax-007微聚焦单元替换过时的Rigaku RU- 200旋转阳极X射线发生器。对于Micromax，我们还需要理学Saturn 944+ CCD探测器和相关设备，整个系统包括一个完整的X射线数据收集系统。RU-200于1992年购买，理学公司宣布不再支持该机器。不可逆的故障随时可能发生，更换的需求非常迫切。该研究所目前拥有两个图像板探测器，一个是从斯坦福大学借来的MAR 345单元，另一个是我们的主力，一个安装在RU-H3 RHB发电机上的R AXIS IV。MAR单元专用于与斯坦福大学合作的机器人晶体安装项目，很少用于正常数据收集。有11个NIH资助的项目--加上一系列更初步的项目--在R轴IV上寻求时间，排队的队伍往往长得令人沮丧。我们认为迫切需要第二个通用数据收集系统。 健康相关性：蛋白质分子执行生物体中的大部分功能，许多药物通过靶向参与疾病过程的蛋白质来发挥作用。所需设备将 使我们能够创建各种蛋白质分子的三维图像。这些图像极大地加快和完善了设计药物的过程，让我们根据蛋白质中的互补位点定制药物。