Acquisition of a Biacore T100 Surface Plasmon Resonance Instrument

描述（申请人提供）：需要一台Biacore T100表面等离子体共振仪。该仪器将被安置在UTHSCSA大分子相互作用中心。它将支持由美国国立卫生研究院7个不同研究所支持的广泛项目，包括国家过敏和传染病研究所（NIAID），国家关节炎和肌肉骨骼和皮肤病研究所（NIAMS），国家癌症研究所（NCI），国家牙科和颅面研究所（NIDCR），国家生物医学成像和生物工程研究所（NIBIB），国家眼科研究所（NEI），国立眼科研究所（NEI），国立癌症研究所（NCI）。国家普通医学科学研究所（NIGMS）和国家神经疾病和中风研究所（NS）。该中心和用户组在表面等离子体共振方法应用于生物医学研究方面拥有广泛的专业知识。但是我们中心的仪器从2001年开始就没有更新过。我们所要求的新技术仪器的选择主要是因为它具有更高的灵敏度，这对于高质量的动力学研究和药物-靶标相互作用的研究尤其重要。这将极大地增强我们的用户组的NIH资助的工作，并将特别有价值的转化研究，特别强调化合物的特性，有望导致改善癌症治疗

DESCRIPTION (provided by applicant): A Biacore T100 Surface Plasmon Resonance instrument is requested. The instrument will be housed in the UTHSCSA Center for Macromolecular Interactions. It will support a wide range of projects that are supported by 7 different NIH institutes including the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Eye Institute (NEI), the National Institute of General Medical Sciences (NIGMS), and the National Institute of Neurological Disorders and Stroke (NS). The center and user group have extensive expertise in the application of surface plasmon resonance approaches to biomedical research. However, the instrumentation in our center has not been updated since 2001. The new state of the art instrument that we are requesting was chosen primarily due to its enhanced sensitivity, which is especially important for high quality kinetic studies, and for the study of drug-target interactions. This will greatly enhance the NIH funded work of our user group, and will be especially valuable for translational research, with a special emphasis on the characterization of compounds expected to lead to improved cancer therapeutics