Acquisition of a Biacore T100 Surface Plasmon Resonance Instrument

购买 Biacore T100 表面等离子共振仪器

• 批准号: 7795416
• 负责人: EILEEN M. LAFER
• 金额: $ 36.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-17 至 2010-12-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795416
• 关键词: Arts; Biomedical Research; Drug Delivery Systems; Funding; Housing; Institutes; Kinetics; Lead; Malignant Neoplasms; National Cancer Institute; National Eye Institute; National Institute of Allergy and Infectious Disease; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Biomedical Imaging and Bioengineering; National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Surface Plasmon Resonance; Therapeutic; Translational Research; United States National Institutes of Health; Update; Work; improved; instrument; instrumentation

DESCRIPTION (provided by applicant): A Biacore T100 Surface Plasmon Resonance instrument is requested. The instrument will be housed in the UTHSCSA Center for Macromolecular Interactions. It will support a wide range of projects that are supported by 7 different NIH institutes including the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Eye Institute (NEI), the National Institute of General Medical Sciences (NIGMS), and the National Institute of Neurological Disorders and Stroke (NS). The center and user group have extensive expertise in the application of surface plasmon resonance approaches to biomedical research. However, the instrumentation in our center has not been updated since 2001. The new state of the art instrument that we are requesting was chosen primarily due to its enhanced sensitivity, which is especially important for high quality kinetic studies, and for the study of drug-target interactions. This will greatly enhance the NIH funded work of our user group, and will be especially valuable for translational research, with a special emphasis on the characterization of compounds expected to lead to improved cancer therapeutics

描述（由申请人提供）：申请使用Biacore T100表面等离子体共振仪器。仪器将存放在UTHSCSA大分子相互作用中心。它将支持由7个不同的NIH研究所支持的广泛项目，包括国家过敏和传染病研究所（NIAID），国家关节炎和肌肉骨骼和皮肤疾病研究所（NIAMS），国家癌症研究所（NCI），国家牙科和颅面研究所（NIDCR），国家生物医学成像和生物工程研究所（NIBIB），国家眼科研究所（NEI）、国家普通医学科学研究所（NIGMS）和国家神经疾病和中风研究所（NS）。该中心和用户组在表面等离子体共振方法应用于生物医学研究方面拥有广泛的专业知识。然而，自2001年以来，我们中心的仪器一直没有更新。选择我们要求的最先进的新仪器主要是因为其灵敏度增强，这对于高质量的动力学研究和药物-靶标相互作用的研究尤其重要。这将极大地增强我们用户组的NIH资助工作，并且对于转化研究特别有价值，特别强调有望改善癌症治疗的化合物的表征