Neuroprotective strategies in seizure-induced damage

癫痫引起的损伤的神经保护策略

• 批准号: 8209124
• 负责人: JANA VELISKOVA
• 金额: $ 34.41万
• 依托单位: NEW YORK MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209124
• 关键词: Action Potentials; Affect; Anxiety; Area; Axon; Back; Budgets; Cell Count; Cells; Charge; Complement; Electrodes; Epilepsy; Equilibrium; Estradiol; Event; Excision; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Female; Fiber; Frequencies; GTP-Binding Proteins; Gender; Glutamates; Grant; Hilar; Hippocampus (Brain); Histology; Immunohistochemistry; In Vitro; Link; Manuscripts; Measures; Mediating; Mental Depression; Metabotropic Glutamate Receptors; Methods; N-Methyl-D-Aspartate Receptors; Neurodegenerative Disorders; Neurons; Neuropeptides; Neurotransmitters; Oils; Output; Peptides; Perforant Pathway; Phase; Physiologic pulse; Physiological; Population; Postsynaptic Membrane; Principal Investigator; Process; Progesterone; Property; Rattus; Records; Research; Research Personnel; Screening procedure; Seizures; Slice; Solutions; Status Epilepticus; Stimulus; Stress; Structure; Surface; Synapses; Synaptic Transmission; System; Testing; Time; Wages; base; dentate gyrus; entorhinal cortex; extracellular; feeding; granule cell; in vivo; insight; male; memory process; metabotropic glutamate receptor 4; neuropeptide Y; neuroprotection; novel; postsynaptic; presynaptic; prevent; programs; receptor; receptor expression; research study; response; stimulus interval; transmission process

项目成果

Prenatal stress promotes development of spasms in infant rats.

• DOI: 10.1111/j.1528-1167.2011.03357.x
• 发表时间: 2012-03
• 期刊: Epilepsia
• 影响因子: 5.6
• 作者: Yum MS;Chachua T;Velíšková J;Velíšek L
• 通讯作者: Velíšek L

New avenue of research: antiepileptic drug and estradiol neuroprotection in epilepsy.

研究新途径：抗癫痫药物和雌二醇对癫痫的神经保护作用。

• DOI: 10.2174/157488908784534577
• 发表时间: 2008
• 期刊: Recent patents on CNS drug discovery
• 作者: Velísek,Libor;Velísková,Jana
• 通讯作者: Velísková,Jana

Gonadal status-dependent effects of in vivo β-estradiol administration to female rats on in vitro epileptiform activity induced by low [Mg2+]₀ in combined hippocampus-entorhinal cortex slices.

雌性大鼠体内β-雌二醇给药对海马-内嗅皮层联合切片中低[Mg2]-诱导的体外癫痫样活动的性腺状态依赖性影响。

• DOI: 10.1016/j.eplepsyres.2013.09.002
• 发表时间: 2013
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Velíšková,Jana;Velíšek,Libor
• 通讯作者: Velíšek,Libor

Anti-seizure medications and estradiol for neuroprotection in epilepsy: the 2013 update.

• DOI: 10.2174/1574889811308010004
• 发表时间: 2013-03
• 期刊: Recent patents on CNS drug discovery
• 作者: L. Velíšek;N. Nebieridze;T. Chachua;J. Velíšková

Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats.

• DOI: 10.1111/j.1528-1167.2012.03674.x
• 发表时间: 2012-11
• 期刊: Epilepsia
• 影响因子: 5.6
• 作者: Chachua T;Poon KL;Yum MS;Nesheiwat L;DeSantis K;Velíšková J;Velíšek L
• 通讯作者: Velíšek L