Spatial-Temporal Dynamics of Blood Flow in the Normal Human Lung

正常人肺血流的时空动态

• 批准号: 8105825
• 负责人: RICHARD BRUCE BUXTON
• 金额: $ 64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105825
• 关键词: Acinus organ component; Age; Altitude; Animal Model; Asthma; Blood; Blood Vessels; Blood flow; Carbon Dioxide; Defect; Disease; Dissociation; Early Diagnosis; Environmental air flow; Exercise; Foundations; Future; Gases; Goals; Health; Heterogeneity; Human; Hypercapnia; Hyperoxia; Hypoxia; Imaging Techniques; Knowledge; Little' s Disease; Lung; Magnetic Resonance Imaging; Measurement; Measures; Methods; Microspheres; Physiological; Population; Predisposition; Pulmonary Edema; Pulmonary Gas Exchange; Pulmonary artery structure; Recovery; Resolution; Rest; Source; Stress; System; Techniques; Testing; Theoretical Studies; Time; Variant; Work; age effect; age related; base; constriction; design; human subject; insight; lung lobe; novel; pressure; response; tool; vasoconstriction

DESCRIPTION (provided by applicant): The overall long-term goal of these studies is to understand the mechanisms by which pulmonary blood flow is controlled, and how that control contributes to gas exchange defects or optimization in health and disease. The specific goal is to use a novel MRI technique to quantify the spatial and temporal dynamics of blood flow in the normal human lung. Temporal heterogeneity in a number of physiological systems has been found to be a mark of healthy function, yet little is known about the temporal dynamics of blood flow in the human lung because the appropriate tools for measuring temporal heterogeneity have not been available. Recently we developed a noninvasive MRI technique that provides quantitative measurements of pulmonary blood flow with a spatial resolution of <1 cm3 and a temporal resolution of ~10 s in the human lung, permitting us to examine spatial-temporal heterogeneity in the human lung for the first time. The Specific Aims are designed to systematically explore the normal spectrum of spatial-temporal heterogeneity, testing: 1) the effects of altered inspired gas (O2 and CO2) in healthy subjects; 2) the effects of exercise; 3) the effects of ageing; and 4) the effects of altered O2 and CO2 in the lungs of subjects susceptible to high altitude pulmonary edema. This will be the first systematic, quantitative study of the spatial and temporal dynamics of pulmonary blood flow in human subjects, and will lay a foundation for applying these methods in the early detection and characterization of disease. PUBLIC HEALTH RELEVANCE: Oxygenation of the blood in the lungs depends on a close matching of ventilation and blood flow: fresh gas and blood flow need to be at the same place and at the same time. We have developed a novel imaging technique for measuring the distribution of blood flow in the human lung not only spatially, but also over time, a measurement that has not been possible before. In this work we will explore the normal dynamics of blood flow as a foundation for applying these methods to identify, and to better understand, the underlying mechanisms of disease.

描述（由申请人提供）：这些研究的总体长期目标是了解控制肺血流的机制，以及该控制如何导致气体交换缺陷或健康和疾病的优化。具体的目标是使用一种新型的MRI技术来量化正常人肺中血流的空间和时间动力学。已经发现许多生理系统中的时间异质性是健康功能的标志，但是对于人类肺中血流的时间动力学知之甚少，因为尚未获得测量时间异质性的适当工具。最近，我们开发了一种非侵入性MRI技术，该技术提供了对肺血流的定量测量，空间分辨率为<1 cm3，在人肺中提供了〜10 s的时间分辨率，使我们能够首次检查人类肺部的空间异质性。该特定目的旨在系统地探索空间异质性的正常频谱，测试：1）在健康受试者中受到启发的气体（O2和CO2）的影响； 2）运动的影响； 3）衰老的影响； 4）易于高空肺水肿的受试者肺中O2和CO2改变的影响。这将是对人类受试者肺血流的空间和时间动力学的首次系统，定量研究，并将为将这些方法应用于疾病的早期检测和表征奠定基础。 公共卫生相关性：肺中血液的氧合取决于通风和血流的密切匹配：新鲜的气体和血流需要在同一位置和同时进行。我们开发了一种新型的成像技术，用于测量人类肺中血流的分布，不仅在空间上，而且随着时间的流逝，这种测量以前是不可能的。在这项工作中，我们将探讨血流的正常动力学，以此作为应用这些方法来识别和更好地理解疾病的潜在机制的基础。