Pre- and Postdoctoral Training in Biochemistry of Aging

描述（由申请人提供）：本申请要求继续进行博士前和博士后联合培训计划。使用尖端的方法，该计划侧重于衰老的细胞，分子和遗传生物化学，解决神经退行性疾病，细胞凋亡，皮肤老化，胰岛素功能，高血压，结缔组织/炎症，受体和骨再生的生物化学等年龄相关领域。该计划以生物化学系为基础，但它合并了其他基础和临床部门的教学和研究优势，如老年服务，波士顿大学阿尔茨海默病核心中心（ADCC），皮肤科，遗传学，药理学，病理学和惠特克高血压研究所。医学系老年科和ADCC的教学和临床优势通过指导学员了解伴随衰老的社会问题来增加该计划。21名核心教员，来自生物化学系，也来自上述学科，作为导师参加该计划。该计划由执行委员会管理，并由咨询委员会审查。申请要求继续目前的总实习生名额：4个博士前和4个博士后职位。培训教师的研究计划以及整个生物化学系都得到了很好的资助，并为学员提供了一个非常好的工作环境。该计划包括正式的课程工作，研讨会，期刊俱乐部，实习生会议和演示以及个人研究项目，适用于基础科学框架内的衰老细胞和分子生物学以及衰老的临床和流行病学方面。该计划有一个很好的记录。在过去10年的36名学员中，有15人现在担任学术教师职务，11人从事非学术研究（许多人是资深科学家），其余的人仍在接受博士后或住院医师的培训。在过去的十年里，他的项目招募了六名少数民族学员。五个人现在不在计划之内，他们做得很好，而一个人目前正在训练。该计划培养年轻科学家，他们计划将自己的生命奉献给减轻或消除与衰老相关的疾病。此外，我们希望我们的许多学员也将致力于延长人类寿命的方法，但有尊严和舒适。

DESCRIPTION (provided by applicant): This application requests continuation of a combined pre and postdoctoral training program. Using cutting edge approaches the program focuses on cellular, molecular and genetic biochemistry of aging, addressing such age related areas as the biochemistry of neurodegenerative disease, apoptosis, dermal aging, insulin function, hypertension, connective tissue/inflammation, receptors and bone regeneration. The program is based in the Biochemistry Department but it merges the teaching and research strengths of other basic and clinical departments such as the Geriatric Service, the Boston University Alzheimer's Disease Core Center (ADCC), the departments of Dermatology, Genetics, Pharmacology, Pathology and the Whitaker Hypertension Institute. The teaching and clinical strengths of the Geriatrics Section of the Department of Medicine and the ADCC add to the program by instructing the trainees in the social issues which accompany senescence. Twenty one core faculty members, from the department of biochemistry but also from the above disciplines, participate as mentors in the program. The program is run by an executive committee and reviewed by and advisory committee. The application requests a continuation of the current number of total trainee slots: 4 predoctoral and 4 postdoctoral positions. The research programs of the training faculty as well as the Department of Biochemistry as a whole are very well funded and provide a very good working environment for the trainee. The program includes formal course work, seminars, journal clubs, trainee meetings and presentations and individual research projects that apply to cell and molecular biology of aging within a framework of basic science and clinical and epidemiological aspects of aging. The program has an excellent record. Of the 36 combined past trainees over the last 10 years, 15 are now in academic faculty positions, 11 are in nonacademic research (many are senior scientists) and the rest are still training as postdocs or residents The program is also involved in active minority recruitment. Within the last ten years he program has recruited six minority trainees. Five are now outside the program and doing very well while one is presently in training. This program trains young scientists who plan to dedicate their lives to alleviate or eliminate diseases associated with aging. In addition we expect that many of our trainees will also work on ways to extend human lifespan but with dignity and in comfort.