PRE- AND POSTDOCTORAL TRAINING IN BIOCHEMISTRY OF AGING

描述：为BUSM为6名博士后和6名博士后研究员提供的机构培训计划要求提供五年的持续支持，总直接费用为1,645,548美元。培训的重点是衰老的细胞和分子生物学，特别强调衰老的生物化学。这项申请将合并位于生物化学系和皮肤科的两个先前独立的NIA赞助的培训项目，并将包括24名对神经生物学、细胞生长、细胞信号、结缔组织生物化学和遗传学研究感兴趣的教职员工。它要求继续保留目前6个博士前和6个博士后职位的实习生职位总数。其中两个博士后名额目前位于皮肤科培训计划中，该计划将纳入该计划。培训包括在老龄化的临床和流行病学方面的框架内，开展关于衰老的细胞和分子生物学领域的正式课程、研讨会、期刊俱乐部和个人研究项目。目标是为博士和医学博士/博士学位培训这些领域的个人，他们将在以后从事老年学研究的独立调查人员的职业生涯。

DESCRIPTION: Five years of continuing support totaling $1,645,548 in direct costs are requested for an institutional training program at BUSM for six predoctoral and six postdoctoral fellows. The training focuses on the cellular and molecular biology of aging, with particular emphasis on the biochemistry of aging. This application will merge two previously independent NIA sponsored training programs located in the Departments of Biochemistry and Dermatology, and will include 24 faculty members with research interests in neurobiology, cell growth, cell signaling, connective tissue biochemistry, and genetics. It requests continuation of the combined current number of trainee slots of six predoctoral and six postdoctoral positions. Two of the postdoctoral slots are presently located in the Department of Dermatology training program which will be incorporated into this program. The training includes formal course work, seminars, journal clubs and individual research projects in the areas of cell and molecular biology of aging within a framework of the clinical and epidemiologic aspects of aging. The goal is to train individuals in these areas for both the Ph.D. and M.D./Ph.D. degrees who will later pursue careers as independent investigators in gerontological research.