PROTEOMIC CHANGES IN MUSCLE CELLS WITH PULMONARY HYPERTENSION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 肺动脉高压(PAH)是一种严重的疾病，其结局通常是致命的。目前还没有可靠的治疗方法，很大程度上是因为生化病因和病程尚不清楚。目前还没有合适的动物模型。我们正在对受影响个体的组织进行蛋白质组学研究，以了解与疾病一起受到影响的途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pulmonary arterial hypertension (PAH) is a devastating disease with a usually fatal outcome There is as yet no reliable treatment for PAH, largely because the biochemical cause and course remain unknown.There are no adequate animal models. We are undertaking proteomics investigations of tissues from affected individuals, in order to gain knowledge about the pathways that are affected in conjunction with the disease.