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Affective Neuroscience of Schizophrenia and Bipolar Disorder

精神分裂症和双相情感障碍的情感神经科学

基本信息

批准号：
8114243
负责人：
WILLIAM P. HORAN
金额：
$ 17.51万
依托单位：
BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8114243
关键词：
Affective Anhedonia Applications Grants Arousal Auditory Benchmarking Biological Markers Bipolar Disorder Blinking Classification Clinical Communities Cues Diagnosis Diagnostic Discrimination Disease Emotional Emotional Disturbance Emotions Event-Related Potentials Funding Goals Impairment Incentives Individual Differences Measures Mental disorders Methods Moods National Institute of Mental Health Neurosciences Research Outcome Outpatients Patient Self-Report Patients Pattern Peripheral Peripheral Nervous System Physiological Process Psychotic Disorders Punishment Reaction Time Recording of previous events Recruitment Activity Research Resistance Rewards Schizophrenia Signal Transduction Stimulus Symptoms System Testing affective neuroscience attenuation base clinical phenotype comparison group disability emotional stimulus endophenotype expectation indexing novel pleasure psychosocial research study response severe mental illness therapy development trait

项目摘要

DESCRIPTION (provided by applicant): Schizophrenia (SCZ) and bipolar disorder-I (BPD) have many similarities, but they have notably different emotional response profiles to appetitive stimuli, and these are present even among clinically stable patients. The goal of this R21 application is to apply current affective neuroscience methods to understand the underlying processes for these different emotional response profiles. We will test hypotheses that stable outpatients with SCZ and euthymic BPD-I patients with a history of psychosis will demonstrate opposite central and peripheral nervous system responses to rewarding stimuli during two types of tasks: affective chronometry, which refers to the temporal parameters (e.g., anticipation, offset) of emotional responding, and motivational engagement, which refers to mobilization of physiological response systems during impending rewards and punishments. 35 SCZ outpatients, 35 euthymic BPD outpatients, and 35 matched healthy controls will complete the two types of paradigms while simultaneous ERP and startle eye blink responses are recorded. Affective chronometry will be measured with a passive emotional picture viewing task with startle probes before, during, and after picture presentation. Motivational engagement will be measured with an active motivational gradient task, in which cues signaling reward or punishment appear to loom progressively closer to the viewer. We predict SCZ patients will demonstrate hypo-reactivity and BPD patients will show hyper-reactivity for specific physiological responses to positive stimuli. Identification of emotional disturbances that are uniquely associated with SCZ and BPD would have direct implications for treatment development and identification of novel endophenotypes. PUBLIC HEALTH RELEVANCE: Schizophrenia (SCZ) and bipolar disorder-I (BPD) are two of the most severely disabling psychiatric disorders, and recent evidence suggests that notably different emotional response abnormalities contribute to poor outcome within each disorder. The goal of this R21 exploratory grant application is to apply affective neuroscience methods to test the hypothesis that stable outpatients with SCZ or BPD-I with a history of psychosis (in a euthymic mood state) will demonstrate differential central and peripheral nervous system responses during tasks that index affective chronometry and motivational engagement. Identification of emotional disturbances that are uniquely associated with each disorder would have direct implications for treatment development and novel emotional endophenotypes.

描述（由申请人提供）：精神分裂症（SCZ）和双相情感障碍i （BPD）有许多相似之处，但它们对食欲刺激的情绪反应谱明显不同，即使在临床稳定的患者中也存在这些差异。本R21应用程序的目标是应用当前的情感神经科学方法来理解这些不同情绪反应概况的潜在过程。我们将检验以下假设：在两种类型的任务中，稳定的SCZ门诊患者和有精神病史的健康BPD-I患者会表现出相反的中枢和外周神经系统对奖励刺激的反应：情感计时，指的是情绪反应的时间参数（例如，预期，抵消）；动机参与，指的是在即将到来的奖励和惩罚期间生理反应系统的动员。将35例SCZ门诊患者、35例胸痹BPD门诊患者和35例匹配的健康对照完成两种范式，同时记录ERP和惊眼眨眼反应。情感计时器将在图片呈现前、期间和之后用惊吓探针进行被动情绪图片观看任务来测量。动机参与将通过一个积极的动机梯度任务来衡量，在这个任务中，暗示奖励或惩罚的线索似乎越来越接近观众。我们预测SCZ患者会表现出低反应性，而BPD患者会表现出对积极刺激的特定生理反应的高反应性。识别与SCZ和BPD独特相关的情绪障碍将对治疗发展和识别新的内表型具有直接意义。