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Exploring neural markers of dyslexia as candidate endophenotypes

探索阅读障碍的神经标志物作为候选内表型

基本信息

批准号：
8054958
负责人：
Thad A Polk
金额：
$ 18.54万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8054958
关键词：
Accounting Affect Alleles Behavior Behavioral Biological Brain Candidate Disease Gene Chromosomes, Human, Pair 6 Cognitive Complex Developmental reading disorder Diffusion Magnetic Resonance Imaging Disease Dyslexia Epigenetic Process Eye Factor Analysis Functional Magnetic Resonance Imaging Future Genes Genetic Risk Genotype Goals Impairment Lead Learning Learning Disabilities Left Light Link Magnetic Resonance Imaging Measurable Measures Participant Pathway interactions Performance Phenotype Process Reading Research Risk Schizophrenia School-Age Population Screening procedure Single Nucleotide Polymorphism Structure Susceptibility Gene Symptoms Variant Work base behavioral impairment endophenotype genetic analysis genome wide association study improved interest lexical magnocellular neuroimaging novel phonology public health relevance relating to nervous system response spelling trait

项目摘要

DESCRIPTION (provided by applicant): Developmental dyslexia is highly heritable, but the search for susceptibility genes is challenging because the pathway from genotype to dyslexic phenotypes is very complex. We hypothesize that neural markers of dyslexia that have been discovered using neuroimaging could be endophenotypes: intermediate traits unseen by the unaided eye that are associated with dyslexia but that are more directly linked to the underlying genotype. We propose to (1) explore the factors underlying neural markers of dyslexia (Aim 1), (2) explore the relationship between the neural factors and behavior (Aim 2) and (3) explore the relationship between the neural factors and a specific genotype that is associated with dyslexia risk (Aim 3). We hope to find a neural factor that is associated with both a behavioral phenotype and an underlying genotype. Such a marker would be a promising candidate endophenotype that could make the search for susceptibility genes more straightforward, and in turn could lead to novel biological treatments for dyslexia in the future. PUBLIC HEALTH RELEVANCE: Identifying the genes that contribute to dyslexia could revolutionize treatment, but is very challenging. We plan to search for a neural signature of dyslexia that is on the pathway from genes to the behavioral impairments in the hopes of making the search for dyslexia genes more straightforward and successful.

描述（由申请人提供）：发育性阅读障碍具有高度遗传性，但由于从基因型到阅读障碍表型的途径非常复杂，因此寻找易感基因具有挑战性。我们假设，使用神经成像技术发现的阅读障碍的神经标记物可能是内表型：肉眼看不到的与阅读障碍相关的中间特征，但与潜在的基因型更直接相关。我们的目标是：（1）探索阅读障碍的神经标记物的潜在因素（目标1），（2）探索神经因素与行为之间的关系（目标2）和（3）探索神经因素与阅读障碍风险相关的特定基因型之间的关系（目标3）。我们希望找到一个神经因子，是与行为表型和潜在的基因型。这样的标记将是一个有前途的候选内表型，可以使易感基因的搜索更直接，反过来可能导致未来的阅读障碍的新的生物治疗。公共卫生相关性：识别导致阅读障碍的基因可能会彻底改变治疗方法，但非常具有挑战性。我们计划寻找从基因到行为障碍的通路上的诵读困难的神经信号，希望使诵读困难基因的寻找更加直接和成功。