Age-related Changes in Neural Distinctiveness: Scope, Causes and Consequences

与年龄相关的神经特征变化：范围、原因和后果

• 批准号: 9103719
• 负责人: Thad A Polk
• 金额: $ 45.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9103719
• 关键词: Age; Aging; Animals; Auditory; Auditory area; Behavior; Behavioral; Benzodiazepines; Brain; Brain region; Cognitive; Disease; Elderly; Emotional; Exhibits; Functional Magnetic Resonance Imaging; GABA Agonists; Hearing; Human; Impairment; Individual Differences; Intervention; Life; Light; Liquid substance; Lorazepam; Magnetic Resonance Spectroscopy; Measures; Memory; Motor; Motor Cortex; Neurologic; Neurotransmitters; Participant; Pattern; Perception; Performance; Process; Research; Sensory; Somatosensory Cortex; Stimulus; Surveys; Testing; Touch sensation; United States National Institutes of Health; Visual; Visual Cortex; Work; age related; aging brain; base; behavioral impairment; cognitive performance; experience; gamma-Aminobutyric Acid; insight; motor control; neuroimaging; normal aging; novel; public health relevance; relating to nervous system; response; somatosensory; young adult

 DESCRIPTION (provided by applicant): Cognitive, sensory, and motor function all usually decline with age, but some people age much more gracefully than others. Why? We hypothesize that one important factor is individual differences in neural distinctiveness. In previous work we've repeatedly found that neural activation patterns in response to different stimuli are significantly less distinctive in older compared with younger adults. Furthermore, we've found that older adults with more distinctive neural representations perform significantly better than others on a range of fluid processing tasks. Animal work confirms these age-related reductions in neural distinctiveness and suggests that declines in the neurotransmitter gamma-aminobutyric acid (GABA) may be an important cause. Building on this work, we propose to investigate the scope, cause, and consequences of age-related changes in neural distinctiveness. First, we will use functional MRI to test whether neural distinctiveness declines in auditory cortex, somatosensory cortex, and motor cortex, like it does in visual cortex (Aim 1: Scope). Second, we will use magnetic resonance spectroscopy to measure GABA levels and use the GABA agonist Lorazepam to manipulate GABA levels in order to investigate whether age-related reductions in GABA cause reductions in neural distinctiveness (Aim 2: Cause). Third, we will collect an extensive battery of measures assessing behavioral performance in the same participants in order to assess the relationship between neural distinctiveness and behavior (Aim 3: Consequences). The proposed studies will provide novel insights into how the brain changes with age, whether those changes can predict successful aging, and whether changes in GABA levels are a contributing cause. Such insights could provide the basis for novel interventions to slow, or conceivably even reverse, the behavioral declines seen during normal aging.