Homeostatic regulation and trafficking of AMPA receptors at single synapses
单突触 AMPA 受体的稳态调节和运输
基本信息
- 批准号:8113426
- 负责人:
- 金额:$ 36.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AMPA ReceptorsAddressApplications GrantsBrainCalciumCell surfaceCellsDataDiffusionEndocytosisEngineeringEventExcisionGlutamate ReceptorHealthIndividualInvestigationLearningLightLocationLong-Term DepressionLong-Term PotentiationLysosomesMediatingMemoryMonitorNeuraxisNeuronsPHluorinPhysiologicalPhysiologyPopulationPotassium ChannelProteasome InhibitorProtein BiosynthesisProteinsReceptor ActivationReceptor CellRegulationResearchRoleSignal TransductionSpinalSurfaceSynapsesSynaptic plasticityTimeUbiquitinVertebral columnVesiclebaseinsightintercellular communicationmanmulticatalytic endopeptidase complexpresynapticprotein degradationreceptorreceptor expressionreceptor internalizationresponsesensortrafficking
项目摘要
DESCRIPTION (provided by applicant): In the central nervous system, a neuron receives a large number of synaptic inputs from many surrounding cells, with individual synapses acting independently of one another. Synaptic plasticity, which is essential for high brain functions including learning and memory, is a synapse autonomous event under physiological conditions. A large amount of data has shown that both Hebbian-type synaptic plasticity including long-term potentiation (LTP) and long-term depression (LTD), as well as non-Hebbian type homeostatic synaptic plasticity are expressed via regulation of synaptic AMPA receptor (AMPAR) abundance, often by vesicle-mediated receptor trafficking. Given the fact that plasticity is highly synapse specific, investigation of synapse specific, activity-dependent regulation of AMPAR expression will provide crucial insights in our understanding of synapse physiology and brain function. Furthermore, homeostatic plasticity has been studied only at the neuronal population level; if and how it is expressed at single synapses remains elusive. To address these issues, we have set up two experimental paradigms in neuronal culture, in which activity levels of identifiable single synapses are specifically regulated. We will investigate the cellular mechanisms by which AMPAR abundance is specifically regulated in response to activity changes at single synapses. PUBLIC HEALTH RELEVANCE: The application aims to understand the mechanisms by which the strength of intercellular communication is regulated in neurons. By investigating synapse specific, activity-dependent regulation of AMPAR expression, this study will provide crucial insights in our understanding of synapse physiology and brain function.
描述(由申请人提供):在中枢神经系统中,神经元接收来自许多周围细胞的大量突触输入,其中各个突触彼此独立地起作用。突触可塑性是在生理条件下发生的突触自主活动,对学习记忆等高级脑功能至关重要。大量数据表明,包括长时程增强(LTP)和长时程抑制(LTD)在内的赫布型突触可塑性以及非赫布型稳态突触可塑性都是通过调节突触AMPA受体(AMPAR)丰度来表达的,通常是通过囊泡介导的受体运输。鉴于可塑性是高度突触特异性的事实,研究突触特异性的、活动依赖性的AMPAR表达调控将为我们理解突触生理学和脑功能提供重要的见解。此外,稳态可塑性仅在神经元群体水平上进行了研究;它是否以及如何在单个突触上表达仍然是难以捉摸的。为了解决这些问题,我们已经建立了两个实验范式,在神经元培养,其中可识别的单个突触的活动水平进行了专门的调节。我们将研究AMPAR丰度在单个突触活动变化中特异性调节的细胞机制。公共卫生关系:该应用程序旨在了解神经元中细胞间通讯强度的调节机制。通过研究突触特异性的、活动依赖性的AMPAR表达调控,这项研究将为我们理解突触生理学和脑功能提供重要的见解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hengye Man其他文献
Hengye Man的其他文献
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{{ truncateString('Hengye Man', 18)}}的其他基金
Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice
NEXMIF 镶嵌表达对雌性小鼠神经元发育和连接的影响研究
- 批准号:
10642436 - 财政年份:2023
- 资助金额:
$ 36.2万 - 项目类别:
Molecular mechanisms of homeostatic synaptic plasticity
稳态突触可塑性的分子机制
- 批准号:
10659418 - 财政年份:2023
- 资助金额:
$ 36.2万 - 项目类别:
Molecular Mechanisms of Homeostatic Synaptic Plasticity
稳态突触可塑性的分子机制
- 批准号:
8818510 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
Homeostatic regulation and trafficking of AMPA receptors at single synapses
单突触 AMPA 受体的稳态调节和运输
- 批准号:
7661422 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
Molecular Mechanisms of Homeostatic Synaptic Plasticity
稳态突触可塑性的分子机制
- 批准号:
9302847 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
Molecular Mechanisms of Homeostatic Synaptic Plasticity
稳态突触可塑性的分子机制
- 批准号:
8922051 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
Homeostatic regulation and trafficking of AMPA receptors at single synapses
单突触 AMPA 受体的稳态调节和运输
- 批准号:
8309377 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
Homeostatic regulation and trafficking of AMPA receptors at single synapses
单突触 AMPA 受体的稳态调节和运输
- 批准号:
7892966 - 财政年份:2008
- 资助金额:
$ 36.2万 - 项目类别:
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