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PK/PD Evaluation Resistance Development in Caseating Granuloma

PK/PD Evaluation Resistance Development in Caseating Granuloma
干酪样肉芽肿的 PK/PD 评估耐药性发展
批准号：
8114048
负责人：
WILLIAM Ramses BISHAI
金额：
$64.62万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-08-07 至 2013-07-31
来源：
https://reporter.nih.gov/project-details/8114048
关键词：
AddressAdjuvant TherapyAnimal ModelAnimalsAnti-Inflammatory AgentsAnti-inflammatoryAntibioticsAutopsyBacteriaCaviaClarithromycinDevelopmentDexamethasoneDoseDrug CombinationsDrug resistanceDrug usageEtanerceptEvaluationFiberFrequenciesGranulomaHigh Pressure Liquid ChromatographyImageImaging technologyImmunosuppressive AgentsIn SituIn VitroInflammationLabelLeadLesionLifeLungMicrobeModelingMusMycobacterium tuberculosisNecrosisOryctolagus cuniculusPathologicPatientsPenetrationPharmaceutical PreparationsPharmacodynamicsPhotonsPositronPositron-Emission TomographyPropertyRecombinantsRelative (related person)ResistanceResistance developmentRoleSamplingSerumSiteSteroidsSystemTNF geneTestingThymidine KinaseTissuesTuberculosisX-Ray Computed Tomographybacterial resistancebasefialuridinefluorodeoxyglucose positron emission tomographyinhibitor/antagonistnoveltooltuberculosis treatment

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Active tuberculosis causes lung cavities where TB-bacteria grow to high levels. Cavitary TB is more transmissible to others, harder to treat in the patient who has it, and more likely to lead to drug resistance. This proposal will combine an animal model in which TB cavities reproducibly develop with novel radiologic imaging technologies and traditional pharmacologic tools to determine whether the TB cavity serves as a sanctuary site where bacteria may escape high drug concentrations and develop resistance. The last part of the study will determine whether giving immunosuppressive drugs which block cavity development together with antibiotics is useful in accelerating cure in an animal model of TB.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge.
DOI： 10.1016/j.tube.2011.07.003
发表时间： 2011-09
期刊： Tuberculosis (Edinburgh, Scotland)
影响因子： --
作者： [Be NA, Klinkenberg LG, Bishai WR, Karakousis PC, Jain SK]
通讯作者： Jain SK
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIV
  • 批准号：
    10557906
  • 项目类别：
  • 资助金额：
    $81.38万
  • 财政年份：
    2022
  • 负责人：
    WILLIAM Ramses BISHAI
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIV
  • 批准号：
    10484064
  • 项目类别：
  • 资助金额：
    $81.38万
  • 财政年份：
    2022
  • 负责人：
    WILLIAM Ramses BISHAI
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Microbiology, Immunology, Animal Modeling and Imaging
  • 批准号：
    10431023
  • 项目类别：
  • 资助金额：
    $13.92万
  • 财政年份：
    2022
  • 负责人：
    WILLIAM Ramses BISHAI
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
Microbiology, Immunology, Animal Modeling and Imaging
  • 批准号：
    10593152
  • 项目类别：
  • 资助金额：
    $14.07万
  • 财政年份：
    2022
  • 负责人：
    WILLIAM Ramses BISHAI
  • 依托单位：
    JOHNS HOPKINS UNIVERSITY
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