Administrative Core

行政核心

基本信息

  • 批准号:
    7983570
  • 负责人:
  • 金额:
    $ 11.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-03 至 2015-07-31
  • 项目状态:
    已结题

项目摘要

The NSBCC administrative Core is described. The NSBCC is Directed by Jim Heath and co-Directed by Mike Phelps & Leroy Hood. Heath bears overall responsibility for the center, and specific responsibility for the technology development components. Dr. Hood bears specific responsibility for oversight of the biology (and systems biology) project components, and Dr. Phelps oversees the clinical translation of NSBCC projects. Each of the NSBCC leaders has extensive expertise in technology development, clinical translation, and technology commercialization. The NSBCC Leaders are guided by an Internal Review Council comprised of the Project Principal Investigators, and by an External Advisory Board. Descriptions of that guidance are provided. Rationale for how the scientific and personnel composition of the individual projects provide for a culture in which the sum of the components is greater than the parts is given - including a proven vision for accelerating the process of technology innovation to clinical demonstration. Significant partnerships with NCI funded programs, including the Jonsson Comprehensive Cancer Center, are described. Leverage from foundation funded programs and institutes, such as the Broad Institute for Regenerative Medicine, are discussed. Additional funding from foundation and other resources provides significant leverage for the NSBCC projects, and significantly accelerates our pathway into the clinic. Additional partnerships with for-profit companies (Sofie Biosciences, Integrated Diagnostics, and Momentum Biosciences) are described. Examples of how these partnerships are already leading to the commercial development of NSBCC technologies (from existing CCNE funding) are provided.
描述了 NSBCC 管理核心。 NSBCC 由 Jim Heath 领导,联合领导 迈克·菲尔普斯和勒罗伊·胡德。 Heath 对中心负有总体责任,并具体负责 技术开发组件。 Hood 博士对生物学的监督负有具体责任 (和系统生物学)项目组成部分,菲尔普斯博士负责监督 NSBCC 的临床转化 项目。 NSBCC 的每一位领导者都在技术开发、临床 翻译和技术商业化。 NSBCC 领导人以内部审查为指导 理事会由项目首席研究员和外部顾问委员会组成。的描述 提供了该指导。个人的科学和人员构成的基本原理 项目提供了一种文化,其中组成部分的总和大于给定的部分 - 包括加速技术创新到临床示范进程的经过验证的愿景。 与 NCI 资助的项目建立了重要的合作伙伴关系,包括 Jonsson 综合癌症中心、 被描述。来自基金会资助的项目和机构的杠杆作用,例如布罗德研究所 再生医学,进行了讨论。来自基金会和其他资源的额外资金提供 对 NSBCC 项目具有重要影响力,并显着加速我们进入临床的进程。 与营利性公司(Sofie Biosciences、Integrated Diagnostics 和 Momentum 生物科学)进行了描述。这些合作伙伴关系如何已经带来商业化的例子 提供 NSBCC 技术的开发(来自现有的 CCNE 资金)。

项目成果

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James R. Heath其他文献

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
  • DOI:
    10.1186/s13073-023-01278-0
  • 发表时间:
    2024-01-06
  • 期刊:
  • 影响因子:
    11.200
  • 作者:
    Daniela Matuozzo;Estelle Talouarn;Astrid Marchal;Peng Zhang;Jeremy Manry;Yoann Seeleuthner;Yu Zhang;Alexandre Bolze;Matthieu Chaldebas;Baptiste Milisavljevic;Adrian Gervais;Paul Bastard;Takaki Asano;Lucy Bizien;Federica Barzaghi;Hassan Abolhassani;Ahmad Abou Tayoun;Alessandro Aiuti;Ilad Alavi Darazam;Luis M. Allende;Rebeca Alonso-Arias;Andrés Augusto Arias;Gokhan Aytekin;Peter Bergman;Simone Bondesan;Yenan T. Bryceson;Ingrid G. Bustos;Oscar Cabrera-Marante;Sheila Carcel;Paola Carrera;Giorgio Casari;Khalil Chaïbi;Roger Colobran;Antonio Condino-Neto;Laura E. Covill;Ottavia M. Delmonte;Loubna El Zein;Carlos Flores;Peter K. Gregersen;Marta Gut;Filomeen Haerynck;Rabih Halwani;Selda Hancerli;Lennart Hammarström;Nevin Hatipoğlu;Adem Karbuz;Sevgi Keles;Christèle Kyheng;Rafael Leon-Lopez;Jose Luis Franco;Davood Mansouri;Javier Martinez-Picado;Ozge Metin Akcan;Isabelle Migeotte;Pierre-Emmanuel Morange;Guillaume Morelle;Andrea Martin-Nalda;Giuseppe Novelli;Antonio Novelli;Tayfun Ozcelik;Figen Palabiyik;Qiang Pan-Hammarström;Rebeca Pérez de Diego;Laura Planas-Serra;Daniel E. Pleguezuelo;Carolina Prando;Aurora Pujol;Luis Felipe Reyes;Jacques G. Rivière;Carlos Rodriguez-Gallego;Julian Rojas;Patrizia Rovere-Querini;Agatha Schlüter;Mohammad Shahrooei;Ali Sobh;Pere Soler-Palacin;Yacine Tandjaoui-Lambiotte;Imran Tipu;Cristina Tresoldi;Jesus Troya;Diederik van de Beek;Mayana Zatz;Pawel Zawadzki;Saleh Zaid Al-Muhsen;Mohammed Faraj Alosaimi;Fahad M. Alsohime;Hagit Baris-Feldman;Manish J. Butte;Stefan N. Constantinescu;Megan A. Cooper;Clifton L. Dalgard;Jacques Fellay;James R. Heath;Yu-Lung Lau;Richard P. Lifton;Tom Maniatis;Trine H. Mogensen;Horst von Bernuth;Alban Lermine;Michel Vidaud;Anne Boland;Jean-François Deleuze;Robert Nussbaum;Amanda Kahn-Kirby;France Mentre;Sarah Tubiana;Guy Gorochov;Florence Tubach;Pierre Hausfater;Isabelle Meyts;Shen-Ying Zhang;Anne Puel;Luigi D. Notarangelo;Stephanie Boisson-Dupuis;Helen C. Su;Bertrand Boisson;Emmanuelle Jouanguy;Jean-Laurent Casanova;Qian Zhang;Laurent Abel;Aurélie Cobat
  • 通讯作者:
    Aurélie Cobat
C60's smallest cousin
C60 的最小“亲戚”
  • DOI:
    10.1038/31579
  • 发表时间:
    1998-06-25
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    James R. Heath
  • 通讯作者:
    James R. Heath
Protein Catalyzed Capture (PCC) Agents for Antigen Targeting.
用于抗原靶向的蛋白质催化捕获 (PCC) 试剂。
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    M. Idso;B. Lai;Heather D Agnew;James R. Heath
  • 通讯作者:
    James R. Heath
Planar Patch-Clamp Electrodes for Single Cell and Neural Network Studies
  • DOI:
    10.1016/j.bpj.2009.12.3287
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    John M. Nagarah;Daniel A. Wagenaar;James R. Heath
  • 通讯作者:
    James R. Heath
Stereochemical engineering of a peptide macrocycle allosteric inhibitor of phospho-Akt2 controls cell penetration by fine-tuning macrocycle-cell membrane interactions
磷酸 Akt2 肽大环变构抑制剂的立体化学工程通过微调大环 - 细胞膜相互作用来控制细胞渗透
  • DOI:
    10.26434/chemrxiv-2021-kldh7
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    5.9
  • 作者:
    Arundhati Nag;A. Mafi;Samir R Das;Mary Beth Yu;Belen Alvarez;W. Goddard;James R. Heath
  • 通讯作者:
    James R. Heath

James R. Heath的其他文献

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{{ truncateString('James R. Heath', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10526102
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)
用于指导序贯靶向抑制剂的时空肿瘤分析:免疫治疗组合(ST-Analytics)
  • 批准号:
    10708901
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
PROJECT 1: TIME-Based Spatiotemporal Cancer Immunograms Predictive for Immunotherapy-Targeted Therapy Sequential Combinations
项目 1:基于时间的时空癌症免疫图预测免疫治疗靶向治疗顺序组合
  • 批准号:
    10907268
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)
用于指导序贯靶向抑制剂的时空肿瘤分析:免疫治疗组合(ST-Analytics)
  • 批准号:
    10526101
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
PROJECT 1: TIME-Based Spatiotemporal Cancer Immunograms Predictive for Immunotherapy-Targeted Therapy Sequential Combinations
项目 1:基于时间的时空癌症免疫图预测免疫治疗靶向治疗顺序组合
  • 批准号:
    10526103
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10708920
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
PROJECT 1: TIME-Based Spatiotemporal Cancer Immunograms Predictive for Immunotherapy-Targeted Therapy Sequential Combinations
项目 1:基于时间的时空癌症免疫图预测免疫治疗靶向治疗顺序组合
  • 批准号:
    10708924
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
Data-driven Patient-Specific Agent Based Models of Metastatic Melanoma for Immunotherapy Response Prediction
用于免疫治疗反应预测的数据驱动的基于患者特异性药物的转移性黑色素瘤模型
  • 批准号:
    10831325
  • 财政年份:
    2022
  • 资助金额:
    $ 11.61万
  • 项目类别:
Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization
用于新抗原特异性 T 细胞捕获和表征的纳米和生物分子工程技术
  • 批准号:
    10297588
  • 财政年份:
    2021
  • 资助金额:
    $ 11.61万
  • 项目类别:
Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization
用于新抗原特异性 T 细胞捕获和表征的纳米和生物分子工程技术
  • 批准号:
    10489832
  • 财政年份:
    2021
  • 资助金额:
    $ 11.61万
  • 项目类别:

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