Stationary Breast Tomosynthesis

固定式乳房断层合成

• 批准号: 7982956
• 负责人: OTTO Z ZHOU
• 金额: $ 12.77万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982956
• 关键词: Algorithms; Anodes; Breast; CCNE1 gene; Carbon; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Detection; Development; Devices; Digital Mammography; Disease; Early Diagnosis; Electron Beam; Electrons; Evaluation; Experimental Designs; Goals; Gold; Healthcare; Heating; Human; Image; Image Analysis; Imaging Phantoms; Imaging Techniques; Instruction; Malignant Neoplasms; Mammary Neoplasms; Marketing; Measurement; Mechanics; Motion; Optics; Patients; Performance; Reader; Research; Research Design; Resolution; Scanning; Screening procedure; Source; Speed; Staging; System; Systems Integration; Technology; Testing; Three-Dimensional Imaging; Time; Validation; Vendor; Woman; Women' s Health; base; calcification; cancer type; design; digital; image processing; improved; malignant breast neoplasm; mortality; next generation; novel; programs; prototype; reconstruction; success

PROJECT SUMMARY (See instructions); Project 5: Stationary Breast Tomosynthesis Breast cancer is the second most common cancer type among women. Over 10% of women develop breast cancer during their lifetimes and 30% to 40% of these patients die from the disease, Eariy detecfion is viewed as the best hope to decrease mortality. Full-field digital mammography (FFDM) is the current gold standard for eariy detecfion but has it limitations. Digital breast tomosynthesis (DBT), a 3-D imaging technique. Is generally considered to be the next generation screening device with the potenfial for improved performance compared to FFDM. In the U.S., DBT scanners from 3 leading commercial vendors are in advanced stages of clinical trials. Recent clinical studies have shown that DBT, while having better detection capability for masses compared to FFDM, suffers from lower sensitivity for micro-calcifications (MC) which is critical for eariy cancer identification. The low MC detectability is attributed mainly to the low image resolufion due to mofion blurring of both the patient and the x-ray source during the relatively long scanning fime. The goal of this project is to develop a novel stationary DBT (s-DBT) technology that has the potential to improve our capability for eariy detection of human breast tumors. The key enabling technology is the carbon nanotube (CNT) based multi-beam field emission x-ray (MBFEX) that was pioneered by our team. During the first CCNE program, we proposed the s-DBT concept and demonstrated the possibility of construcfing a s-DBT scanner with significantly increased scanning speed and spafial resolufion compared to the current DBT technology. Our hypothesis is that the high spatial resolution will improve the sensitivity for both masses and micro-calcifications. In addition, the fast scanning speed will reduce patient discomfort due to prolonged compression. For this project we will develop a clinical-test ready prototype s-DBT system and validate its performance through phantom measurements and reader studies. The research will be carried out in close collaboration with Hologic, a market leader in women's healthcare and one ofthe major developers of the DBT technology.

项目总结（见说明书）；