Stationary Breast Tomosynthesis

项目总结(见说明)； 项目5：固定式乳房断层合成 乳腺癌是女性中第二常见的癌症类型。超过10%的女性发育为乳房 癌症，这些患者中有30%到40%死于这种疾病，Eariy检测到 被视为降低死亡率的最大希望。全视野数字化乳房X光摄影是目前的黄金技术 早期检测的标准，但有其局限性。数字乳房断层合成(DBT)，一种三维成像 技术。被普遍认为是下一代筛查设备，具有改进的潜力 与FFDM相比的性能。在美国，来自3家领先商业供应商的DBT扫描仪已进入 临床试验的高级阶段。最近的临床研究表明，DBT虽然有更好的检测能力 与FFDM相比，对肿块的能力对微钙化(MC)的敏感度较低 对癌症的早期识别至关重要。低MC可探测性主要归因于低图像 由于患者和X射线源在相对较长的扫描过程中的Mofion模糊而导致的分辨率 FIME。本项目的目标是开发一种具有潜在潜力的新型固定式DBT(S-DBT)技术 以提高我们早期发现人类乳房肿瘤的能力。关键的使能技术是 基于碳纳米管(CNT)的多束场发射X射线(MBFEX)是我们团队首创的。 在第一个CCNE项目中，我们提出了S-DBT的概念，并论证了 构建扫描速度和空间分辨率均有明显提高的S-DBT扫描仪 到目前的DBT技术。我们的假设是，高空间分辨率将提高灵敏度。 对肿块和微钙化都适用。此外，快速的扫描速度将减少患者的不适 由于长时间的压缩。在这个项目中，我们将开发一个可用于临床测试的S-DBT系统原型 并通过体模测量和读者研究来验证其性能。这项研究将是 与霍洛奇密切合作进行的，霍洛奇是女性医疗保健的市场领先者，也是 DBT技术的开发商。

PROJECT SUMMARY (See instructions); Project 5: Stationary Breast Tomosynthesis Breast cancer is the second most common cancer type among women. Over 10% of women develop breast cancer during their lifetimes and 30% to 40% of these patients die from the disease, Eariy detecfion is viewed as the best hope to decrease mortality. Full-field digital mammography (FFDM) is the current gold standard for eariy detecfion but has it limitations. Digital breast tomosynthesis (DBT), a 3-D imaging technique. Is generally considered to be the next generation screening device with the potenfial for improved performance compared to FFDM. In the U.S., DBT scanners from 3 leading commercial vendors are in advanced stages of clinical trials. Recent clinical studies have shown that DBT, while having better detection capability for masses compared to FFDM, suffers from lower sensitivity for micro-calcifications (MC) which is critical for eariy cancer identification. The low MC detectability is attributed mainly to the low image resolufion due to mofion blurring of both the patient and the x-ray source during the relatively long scanning fime. The goal of this project is to develop a novel stationary DBT (s-DBT) technology that has the potential to improve our capability for eariy detection of human breast tumors. The key enabling technology is the carbon nanotube (CNT) based multi-beam field emission x-ray (MBFEX) that was pioneered by our team. During the first CCNE program, we proposed the s-DBT concept and demonstrated the possibility of construcfing a s-DBT scanner with significantly increased scanning speed and spafial resolufion compared to the current DBT technology. Our hypothesis is that the high spatial resolution will improve the sensitivity for both masses and micro-calcifications. In addition, the fast scanning speed will reduce patient discomfort due to prolonged compression. For this project we will develop a clinical-test ready prototype s-DBT system and validate its performance through phantom measurements and reader studies. The research will be carried out in close collaboration with Hologic, a market leader in women's healthcare and one ofthe major developers of the DBT technology.