Next Generation Digital Breast Tomosynthesis Scanner

下一代数字乳腺断层合成扫描仪

基本信息

批准号：
8255563
负责人：
OTTO Z ZHOU
金额：
$ 39.52万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-19 至 2014-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Mammography is currently the most effective screening and diagnostic tool for early detection of breast cancer. However the current 2-view mammography method lacks sensitivity and has a very high false alarm rate. X-ray digital breast tomosynthesis (DBT) is an emerging technique for producing multi-slice images to provide depth resolution and improved contrast. The goal of this proposal is to develop the next generation DBT scanner with significantly improved system performance at potentially reduced dose and cost. All current commercial prototype DBT scanners use a regular full-field digital mammography (FFDM) system to generate a series of projection views from a limited angle range using a single x-ray source that moves along an arc above the compressed breast. Such scanners have several intrinsic limitations including: 1) the source rotation leads to long scanning time and discomfort for patients from breast compression; and 2) the slow motion of the source leads to motion blurring and system instability that limited the spatial resolution. In addition the long scanning time prevents the adaptation of advanced imaging methods such as dual energy and quasi-monochromatic, and k- edge imaging which can potentially provide better contrast and reduce imaging dose. We propose to develop a novel stationary DBT scanner to mitigate the above limitations. This proposed device is based on the new carbon nanotube (CNT) multi-pixel field emission x- ray (MBFEX) technology invented and demonstrated by our team. The scanner will be designed to offer the following advantages over the current commercial units: a factor of 10 increase of the imaging speed; increased spatial resolution; simplified system design and reduced cost; and dual energy and quasi-monochromatic imaging at a reasonable scanning time. The feasibility of the proposed device has been demonstrated. The goal of this proposal is to take this technology to the next level moving from a laboratory proof-of-concept assembly to a fully functional system that will be used for clinical studies. We have formed a partnership comprising an interdisciplinary team from the University of North Carolina Chapel Hill (UNC), Southern Illinois University (SIU), and XinRay Systems - a Siemens and Xintek Joint Venture (XinRay). The UNC team pioneered the CNT MBFEX technology and the stationary tomography imaging concept. XinRay was recently established specifically for the purpose of manufacturing and commercializing the MBFEX technology for x-ray imaging. The group at SIU has extensive experiences is reconstruction and image analysis for breast tomosynthesis. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to develop the next generation digital breast tomosynthesis (DBT) scanner for detection and diagnostic of human breast cancer with significantly improved imaging speed and resolution, and potentially reduced dose and cost. To perform this work we have formed a partnership comprising an interdisciplinary team from the University of North Carolina Chapel Hill (UNC), Southern Illinois University (SIU), and XinRay Systems - a Siemens and Xintek Joint Venture (XinRay). The optimized device will be installed at the UNC medical school as a shared imaging facility and for future clinical studies

描述（由申请人提供）：乳房X线摄影是目前最有效的筛查和诊断工具，用于早期检测乳腺癌。但是，当前的2视乳房X线摄影方法缺乏灵敏度，并且错误警报率很高。 X射线数字乳房断层合成（DBT）是一种新兴技术，用于产生多板图像，以提供深度分辨率和改进的对比度。该提案的目的是开发下一代DBT扫描仪，并在潜在降低剂量和成本下大大提高了系统性能。所有当前的商业原型DBT扫描仪都使用常规的全场数字乳房X线摄影（FFDM）系统，使用单个X射线源从有限的角度范围内生成一系列投影视图，该X射线源沿压缩乳房上方移动。这样的扫描仪具有几个固有的局限性，包括：1）源旋转会导致长时间的扫描时间和乳房压缩患者的不适； 2）源的慢动作会导致运动模糊和系统不稳定性，从而限制了空间分辨率。此外，长时间的扫描时间可防止高级成像方法的适应，例如双能和准单色和k-边成像，它们可能会提供更好的对比度并减少成像剂量。我们建议开发一种新型的固定DBT扫描仪来减轻上述局限性。该提出的设备基于新的碳纳米管（CNT）多像素场发射X- Ray（MBFEX）技术由我们的团队发明和演示。该扫描仪将旨在提供以下优势，比当前的商业单位：成像速度增加10倍；空间分辨率增加；简化的系统设计和降低的成本；以及在合理的扫描时间进行双重能量和准单色成像。已经证明了该设备的可行性。该提案的目的是将这项技术提升到从实验室概念验证组件转变为将用于临床研究的功能齐全的系统。我们建立了一个合作伙伴关系，包括北卡罗来纳大学教堂山（UNC），南伊利诺伊大学（SIU）和Xinray Systems的跨学科团队 - 西门子和Xintek合资企业（Xinray）。 UNC团队开创了CNT MBFEX技术和固定断层扫描成像概念。 Xinray最近是为了制造和商业化用于X射线成像的MBFEX技术的目的而建立的。 SIU的小组具有丰富的经验，这是乳房合成的重建和图像分析。公共卫生相关性：该提案的目的是开发下一代数字乳房合成（DBT）扫描仪，以检测和诊断人类乳腺癌，并具有显着改善的成像速度和分辨率，并有可能降低剂量和成本。为了执行这项工作，我们建立了一个合作伙伴关系，包括来自北卡罗来纳大学教堂山（UNC），南伊利诺伊大学（SIU）和Xinray Systems的跨学科团队 - 西门子和Xintek合资企业（Xinray）。优化的设备将作为共享成像设施安装在UNC医学院，并为将来的临床研究安装