Carolina Center of Cancer Nanotechnology Excellence

卡罗莱纳州癌症纳米技术卓越中心

• 批准号: 7963527
• 负责人: JOSEPH M. DESIMONE
• 金额: $ 259.09万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963527
• 关键词: Carolina; Center; Cancer; Nanotechnology; Excellence

The Carolina CCNE is focused on improving cancer disease control and management by utilizing exciting new and cutting edge nanotechnologies, developed from our first CCNE efforts,. Our efforts will work to improve the quality and duration of life and disease outcome for cancer patients by enhancing treatment and early detection. We propose five projects in two major areas as follows: Nano-Particle Based Biological and Chemotherapy includes Project 1: PRINT Nanoparticles: "Calibration Quality" Nano-tools for Studying Particle Biodistribution, Project 2: Ras pathway siRNA in Lung Cancer, and Project 3: Translational Nanosystems Chemotherapy in Lung Cancer. Carbon Nanotube Based Radiation Therapy and Early Detection include Project 4: Compact Micro Beam Radiation Therapy in Brain Cancer and Project 5: Digital Breast Tomosynthesis System. The proposed nanoparticle science is primarily focused on targeted delivery of biological (siRNA) and chemotherapy to cancer cells. A key basic science question we will address is the implications of nanoparticle size, shape and modulus in accessing various tissues in the body. This question can effectively be answered by the UNC-developed PRINT technology, which features exquisite control over particle properties and will result in the establishment of BioMaps for nanoparticle delivery. Two additional nanoparticle-based projects will deliver biological and chemotherapy in a targeted fashion to lung cancer, with four distinct nanoparticle types that are capable of carrying multiple payloads. We will establish the first direct comparison of efficacy and toxicity of these various approaches against the equivalent of clinical standard of care in sophisticated murine cancer models. With carbon nanotube-based field emission X-ray technology, a new compact microbeam radiation therapy source is proposed that will deliver high intensity and spatially distributed radiotherapy to high grade gliomas and other brain cancers. Lastly, a carbon nanotube-based clinic-ready breast tomosynthesis imaging device is proposed that would advance early detection and characterization of breast abnormalities, and help to distinguish cancer from benign disease. We believe that developing these technologies and preparing them for clinical trials will help in realizing the promise of nanotechnology in cancer care and positively impact the lives of cancer patients. Public Health Relevance: Nanotechnology can be part of an improved cancer management effort. The need for targeted delivery systems, capable of carrying multiple and varied payloads, coupled with early detection, is a prerequisite for efficient therapy and reduced toxicity leading to improved outcomes.

卡罗莱纳州 CCNE 致力于通过利用我们第一个 CCNE 努力开发的令人兴奋的新型尖端纳米技术来改善癌症疾病控制和管理。我们将努力通过加强治疗和早期检测来改善癌症患者的生命质量、寿命和疾病结果。我们提出了以下两个主要领域的五个项目：基于纳米颗粒的生物和化疗包括项目1：PRINT纳米颗粒：用于研究颗粒生物分布的“校准质量”纳米工具，项目2：肺癌中的Ras途径siRNA，以及项目3：肺癌中的转化纳米系统化疗。基于碳纳米管的放射治疗和早期检测包括项目4：脑癌紧凑型微束放射治疗和项目5：数字乳腺断层合成系统。所提出的纳米粒子科学主要集中于向癌细胞靶向递送生物（siRNA）和化疗。我们将解决的一个关键的基础科学问题是纳米颗粒的尺寸、形状和模量对进入体内各种组织的影响。北卡罗来纳大学开发的 PRINT 技术可以有效地回答这个问题，该技术具有对颗粒特性的精确控制，并将导致建立用于纳米颗粒输送的 BioMaps。另外两个基于纳米颗粒的项目将以有针对性的方式为肺癌提供生物和化疗，其中有四种不同的纳米颗粒类型能够携带多种有效载荷。我们将首次将这些不同方法的功效和毒性与复杂的小鼠癌症模型中的临床护理标准进行直接比较。利用基于碳纳米管的场发射 X 射线技术，提出了一种新型紧凑型微束放射治疗源，可为高级神经胶质瘤和其他脑癌提供高强度和空间分布的放射治疗。最后，提出了一种基于碳纳米管的临床就绪乳腺断层合成成像设备，该设备将促进乳腺异常的早期检测和表征，并有助于区分癌症和良性疾病。我们相信，开发这些技术并为临床试验做好准备将有助于实现纳米技术在癌症治疗中的前景，并对癌症患者的生活产生积极影响。 公共卫生相关性：纳米技术可以成为改善癌症管理工作的一部分。对能够携带多种不同有效负载的靶向递送系统的需求，加上早期检测，是有效治疗和减少毒性从而改善结果的先决条件。