South Carolina Cancer Disparities Research Center (SC CaDRe)

SC 干部 1U54CA210963-01A1 过桥资金 摘要 这项为期五年的 U54 提案是一项协作性、机构间伙伴关系 南卡罗来纳州立大学 (SCSU)、一所历史悠久的黑人大学 (HBCU) 和 南卡罗来纳医科大学霍林斯癌症中心 (MUSC-HCC) 癌症研究所指定癌症中心。该合作伙伴关系于 2011 年在一家公司的支持下开始 NCI P20 CPACHE 拨款并已发展到产生 U54 南卡罗来纳州癌症差异 研究中心（SC CADRE）申请。根据联合社区合作伙伴的意见， 奥兰治堡马布里癌症中心区域医疗中心 (RMC-MCC)，两个机构的研究人员 各机构合作设计了 SC CADRE。 SC CADRE 的总体目标是 提高 SCSU 进行跨学科癌症研究的能力并进一步加强 并扩展纵向研究教育渠道，以促进新一代多样化的人才 生物医学研究人员关注癌症差异。 SC 干部有三大主题。 第一个重点是评估肥胖与前列腺癌和乳腺癌之间的关系 差异。第二个主题强调晚期糖基化终末产物（AGE）的评估 作为与癌症、癌症差异和肥胖相关的新型生物标志物。第三个主题亮点 包括美国东南沿海地区海岛特有的人口 (SI)/古拉人口。五年内，SC CADRE 的目标是： 1) 进一步阐明 导致癌症差异的分子机制； 2）丰富的多元化渠道 癌症研究人员； 3) 由 SCSU 教师领导的 NIH 研究提案数量增加 独立调查员； 4) 社区更多地参与癌症研究。由于 SCSU / MUSC-HCC 的长期学术合作伙伴关系以及每个实体的研究和 凭借教育优势和社区关系，SC CADRE 有望改变癌症 南卡罗来纳州居民的健康状况

SC CADRE 1U54CA210963-01A1 Bridge Funding SUMMARY This five-year U54 proposal is a collaborative, inter-institutional partnership between South Carolina State University (SCSU), an Historically Black University (HBCU), and the Medical University of South Carolina Hollings Cancer Center (MUSC-HCC), a National Cancer Institute-designated cancer center. The partnership began in 2011 under the auspices of an NCI P20 CPACHE grant and has grown to produce this U54 South Carolina Cancer Disparities Research Center (SC CADRE) application. With input from their joint community partner, the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC), investigators at both institutions collaborated to design the SC CADRE. The overarching goals of the SC CADRE are to increase SCSU’s capacity to conduct transdisciplinary cancer research and to further strengthen and extend a longitudinal research education pipeline that will catalyze a new diverse generation of biomedical researchers focused on cancer disparities. The SC CADRE has three major themes. The first focuses on evaluating the relationship between obesity and prostate and breast cancer disparities. The second theme emphasizes evaluation of advanced glycation endproducts (AGEs) as a novel biomarker related to cancer, cancer disparities, and obesity. The third theme highlights the inclusion of a population unique to the US southeastern coastal region, the Sea Island (SI)/Gullah population. Within five years, the SC CADRE aims for: 1) further elucidation of molecular mechanisms contributing to cancer disparities; 2) an enhanced pipeline of diverse cancer researchers; 3) an increased number of NIH research proposals led by SCSU faculty as independent investigators; and 4) greater community engagement in cancer research. Due to the longstanding SCSU /MUSC-HCC academic partnership and each entity’s research and educational strengths and community relationships, the SC CADRE is poised to transform cancer health outcomes for South Carolinians