South Carolina Cancer Disparities Research Center (SC CaDRe)

SC CADRE 1U54CA210963 - 01A1 桥梁资金 U54五年期提案是一个协作性的机构间伙伴关系， 南卡罗来纳州州立大学（SCSU），历史上的黑人大学（HBCU），和 南卡罗来纳州霍林斯癌症中心医科大学（MUSC-HCC），一个国家级的 癌症研究所指定的癌症中心。该伙伴关系始于2011年， NCI P20 CPACHE补助金，并已发展到产生这种U54南卡罗来纳州癌症差异 研究中心（SC CADRE）申请。通过他们的联合社区合作伙伴的投入， 奥兰治堡马布里癌症中心区域医疗中心（RMC-MCC）， 机构合作设计SC CADRE。SC CADRE的总体目标是 提高SCSU进行跨学科癌症研究的能力，并进一步加强 并延伸纵向研究教育管道，这将促进新一代多样化的教育， 生物医学研究人员关注癌症差异。SC CADRE有三大主题。 第一项研究的重点是评估肥胖与前列腺癌和乳腺癌之间的关系 差距。第二个主题强调晚期糖基化终产物（AGEs）的评价 作为一种与癌症、癌症差异和肥胖相关的新生物标志物。第三个主题突出 包括美国东南沿海地区特有的人口，海岛 (SI)/Gullah人。在五年内，SC CADRE的目标是：1）进一步阐明 导致癌症差异的分子机制; 2）增强的多样化 癌症研究人员; 3）由SCSU教师领导的NIH研究提案数量增加， 独立研究者; 4）更多的社区参与癌症研究。由于 SCSU/MUSC-HCC长期的学术合作伙伴关系以及每个实体的研究和 教育优势和社区关系，SC CADRE准备改变癌症 南卡罗来纳州的健康结果

SC CADRE 1U54CA210963-01A1 Bridge Funding SUMMARY This five-year U54 proposal is a collaborative, inter-institutional partnership between South Carolina State University (SCSU), an Historically Black University (HBCU), and the Medical University of South Carolina Hollings Cancer Center (MUSC-HCC), a National Cancer Institute-designated cancer center. The partnership began in 2011 under the auspices of an NCI P20 CPACHE grant and has grown to produce this U54 South Carolina Cancer Disparities Research Center (SC CADRE) application. With input from their joint community partner, the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC), investigators at both institutions collaborated to design the SC CADRE. The overarching goals of the SC CADRE are to increase SCSU’s capacity to conduct transdisciplinary cancer research and to further strengthen and extend a longitudinal research education pipeline that will catalyze a new diverse generation of biomedical researchers focused on cancer disparities. The SC CADRE has three major themes. The first focuses on evaluating the relationship between obesity and prostate and breast cancer disparities. The second theme emphasizes evaluation of advanced glycation endproducts (AGEs) as a novel biomarker related to cancer, cancer disparities, and obesity. The third theme highlights the inclusion of a population unique to the US southeastern coastal region, the Sea Island (SI)/Gullah population. Within five years, the SC CADRE aims for: 1) further elucidation of molecular mechanisms contributing to cancer disparities; 2) an enhanced pipeline of diverse cancer researchers; 3) an increased number of NIH research proposals led by SCSU faculty as independent investigators; and 4) greater community engagement in cancer research. Due to the longstanding SCSU /MUSC-HCC academic partnership and each entity’s research and educational strengths and community relationships, the SC CADRE is poised to transform cancer health outcomes for South Carolinians