South Carolina Cancer Disparities Research Center (SC CADRE)

总结 这项为期五年的U54提案是南卡罗来纳州与 南卡罗来纳州立大学（SCSU），历史上的黑人大学（HBCU）和南卡罗来纳州医科大学 Hollings癌症中心（MUSC-HCC），国家癌症研究所指定的癌症中心。伙伴关系 在NCI P20 CPACHE赠款的赞助下于2011年开始，并已发展到生产这种U54南 卡罗莱纳癌症差异研究中心（SC CADRE）申请。通过他们共同社区的投入， 合作伙伴，奥兰治堡马布里癌症中心（RMC-MCC）的区域医疗中心，研究人员在这两个 机构合作设计SC CADRE。SC CADRE的总体目标是增加 SCSU进行跨学科癌症研究的能力，并进一步加强和扩大 纵向研究教育管道，将促进新一代多样化的生物医学研究人员 关注癌症差异。SC CADRE有三大主题。第一个重点是评估 肥胖与前列腺癌和乳腺癌之间的差异。第二个主题强调 晚期糖基化终产物（AGEs）作为一种与癌症相关的新型生物标志物的评价， 差异和肥胖。第三个主题突出了美国东南部独特的人口 沿海地区，海岛（SI）/Gullah人口。在五年内，SC CADRE的目标是：1）进一步 阐明了导致癌症差异的分子机制; 2）增强了多种 癌症研究人员; 3）由SCSU教师领导的NIH研究提案数量增加， 研究人员;和4）更多的社区参与癌症研究。由于长期的SCSU /MUSC-HCC学术合作伙伴关系以及每个实体的研究和教育优势和社区 关系，SC CADRE准备改变南卡罗来纳州的癌症健康结果。

SUMMARY This five-year U54 proposal is a collaborative, inter-institutional partnership between South Carolina State University (SCSU), an Historically Black University (HBCU), and the Medical University of South Carolina Hollings Cancer Center (MUSC-HCC), a National Cancer Institute-designated cancer center. The partnership began in 2011 under the auspices of an NCI P20 CPACHE grant and has grown to produce this U54 South Carolina Cancer Disparities Research Center (SC CADRE) application. With input from their joint community partner, the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC), investigators at both institutions collaborated to design the SC CADRE. The overarching goals of the SC CADRE are to increase SCSU's capacity to conduct transdisciplinary cancer research and to further strengthen and extend a longitudinal research education pipeline that will catalyze a new diverse generation of biomedical researchers focused on cancer disparities. The SC CADRE has three major themes. The first focuses on evaluating the relationship between obesity and prostate and breast cancer disparities. The second theme emphasizes evaluation of advanced glycation endproducts (AGEs) as a novel biomarker related to cancer, cancer disparities, and obesity. The third theme highlights the inclusion of a population unique to the US southeastern coastal region, the Sea Island (SI)/Gullah population. Within five years, the SC CADRE aims for: 1) further elucidation of molecular mechanisms contributing to cancer disparities; 2) an enhanced pipeline of diverse cancer researchers; 3) an increased number of NIH research proposals led by SCSU faculty as independent investigators; and 4) greater community engagement in cancer research. Due to the longstanding SCSU /MUSC-HCC academic partnership and each entity's research and educational strengths and community relationships, the SC CADRE is poised to transform cancer health outcomes for South Carolinians.