South Carolina Cancer Disparities Research Center (SC CADRE)

摘要 这项为期五年的U54提案是南卡罗来纳州之间的合作、机构间伙伴关系 历史悠久的黑人大学(HBCU)和南卡罗来纳医科大学 霍林斯癌症中心(MUSC-HCC)，国家癌症研究所指定的癌症中心。合作伙伴关系 在NCI P20 CPACHE赠款的赞助下于2011年开始，并已发展到生产U54 South 卡罗莱纳州癌症差异研究中心(SC CADRE)的申请。来自他们共同社区的投入 合作伙伴，奥兰治堡马布里癌症中心区域医疗中心(RMC-MCC)，两家公司的调查人员 各机构合作设计了SC干部。高级管理干部的首要目标是增加 SCSU进行跨学科癌症研究的能力以及进一步加强和扩大 纵向研究教育管道将催化新一代多样化的生物医学研究人员 重点关注癌症的差异。SC干部有三大主题。第一个重点是评估 肥胖与前列腺癌和乳腺癌差异的关系。第二个主题强调 晚期糖基化终产物(AGEs)作为与癌症相关的新生物标志物的评价 差异和肥胖症。第三个主题突出了美国东南部独有的人口 沿海地区，海岛(SI)/古拉人口。在五年内，SC干部的目标是：1)进一步 阐明导致癌症差异的分子机制；2)增强不同 癌症研究人员；3)由南加州大学教职员工独立领导的NIH研究提案数量增加 研究人员；以及4)社区更多地参与癌症研究。由于华南理工大学的历史悠久 /MUSC-CC学术伙伴关系以及每个实体的研究和教育优势以及社区 这位SC干部正准备改变南卡罗来纳州人的癌症健康结果。

SUMMARY This five-year U54 proposal is a collaborative, inter-institutional partnership between South Carolina State University (SCSU), an Historically Black University (HBCU), and the Medical University of South Carolina Hollings Cancer Center (MUSC-HCC), a National Cancer Institute-designated cancer center. The partnership began in 2011 under the auspices of an NCI P20 CPACHE grant and has grown to produce this U54 South Carolina Cancer Disparities Research Center (SC CADRE) application. With input from their joint community partner, the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC), investigators at both institutions collaborated to design the SC CADRE. The overarching goals of the SC CADRE are to increase SCSU's capacity to conduct transdisciplinary cancer research and to further strengthen and extend a longitudinal research education pipeline that will catalyze a new diverse generation of biomedical researchers focused on cancer disparities. The SC CADRE has three major themes. The first focuses on evaluating the relationship between obesity and prostate and breast cancer disparities. The second theme emphasizes evaluation of advanced glycation endproducts (AGEs) as a novel biomarker related to cancer, cancer disparities, and obesity. The third theme highlights the inclusion of a population unique to the US southeastern coastal region, the Sea Island (SI)/Gullah population. Within five years, the SC CADRE aims for: 1) further elucidation of molecular mechanisms contributing to cancer disparities; 2) an enhanced pipeline of diverse cancer researchers; 3) an increased number of NIH research proposals led by SCSU faculty as independent investigators; and 4) greater community engagement in cancer research. Due to the longstanding SCSU /MUSC-HCC academic partnership and each entity's research and educational strengths and community relationships, the SC CADRE is poised to transform cancer health outcomes for South Carolinians.