Imaging Core

成像核心

• 批准号: 7984287
• 负责人: Craig F Ferris
• 金额: $ 14.75万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7984287
• 关键词: Animal Disease Models; Biodistribution; Data; Data Analyses; Data Storage and Retrieval; Detection; Diagnostic; Disease model; Faculty; Functional Imaging; Housing; Human Resources; Image; Imagery; Intervention; Intervention Studies; Kinetics; Label; Libraries; Longitudinal Studies; Measurement; Metric; Modeling; Monitor; Online Systems; Organ; Pharmaceutical Preparations; Positron-Emission Tomography; Property; Protocols documentation; Radio; Research Personnel; Resolution; Schedule; System; Therapeutic Intervention; Time; Universities; base; data acquisition; disease diagnosis; drug development; experience; in vivo; instrumentation; neuroimaging; novel; oncology; pre-clinical; protocol development; repository; single photon emission computed tomography; tumor

Imaging Core The imaging capabilities at the Center for Translational Neuroimaging at Northeastern University offer unique capabilities for the visualization of nanopreparations in vivo. The center currently houses a high-resolution microSPECT/CT (NanoSPECT/CT, Bioscan, Inc.) and a 7T MR system (BioSpec, Bruker Biospin, Inc.) with a microPET to be installed in Q4 of this year. With extensive experience in onco-based imaging protocols, the imaging core enables the assessment of kinetics and dynamics of radio-labeled nanopreparations via SPECT and PET as well as nanopreparations for contrast enhanced MR studies. Multi-modal data acquisition support projects in drug development, intervention monitoring, disease diagnosis and tracking, and functional imaging. In addition to instrumentation and protocol development, the core offers a library of analysis functions for longitudinal studies of animal models of disease. Such functionality focuses on the tracking of nanopreparations via standard in vivo and ex vivo biodistribution analysis as well as novel sub-organ and sub-tumor metrics of distribution. The core hosts data and analysis results on a web-based data storage and analysis center dedicated to pre-clinical longitudinal imaging studies. Faculty and collaborating researchers have real-time access to data via the web-based repository along with remote scheduling and study-planning capabilities.

成像核心 东北大学翻译神经成像中心的成像能力 为体内纳米修复的可视化提供独特的能力。该中心目前拥有一台高分辨率的MicroSPECT/CT(NanoSPECT/CT，BioSCAN，Inc.)和7T磁共振系统(BioSpec， Bruker Biospin，Inc.今年第四季度将安装一台微型PET。在以下领域拥有丰富经验 基于肿瘤的成像协议，成像核心能够通过SPECT和PET评估放射性标记纳米修复的动力学和动力学，以及用于对比的纳米修复 增强了磁共振研究。在药物开发、干预监测、疾病诊断和跟踪以及功能成像方面的多模式数据获取支持项目。除了仪器和方案开发，该核心还为疾病动物模型的纵向研究提供了一个分析函数库。这种功能侧重于通过标准的体内和体外生物分布分析以及新的亚器官和亚肿瘤分布度量来跟踪纳米修复。 CORE在一个基于网络的数据存储和分析中心上托管数据和分析结果，该中心致力于临床前纵向成像研究。教师和协作研究人员可以通过基于Web的存储库实时访问数据，以及远程日程安排和学习规划功能。