BRAIN FUNCTION IN SOCIAL AFFILIATION AND PARENTAL MOTIVATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究与配偶关系和父母动机有关的大脑通路。 功能磁共振成像(FMRI)是在清醒的雄性绒猴身上进行的，当它们被呈现出来自(熟悉的或陌生的)成年雌性和婴儿的单独气味时。我们已经开发出了从雌性气味和婴儿气味向雄性绒猴提供嗅觉刺激的方法(Ziegler等人，2005年)。在10分钟的展示中，七只雄性绒猴被呈现给他们自己的婴儿的气味，而雄性绒猴则处于隔离状态。男性在出现症状30分钟后放血，并分析血清中素和皮质醇的含量。在一个交叉设计中，男性被呈现给他们自己的婴儿气味或车辆控制的气味。雄性在与婴儿气味相互作用后，睾酮水平显着下降，而在提供对照刺激后，雄性成年绒猴的睾酮水平并没有改变。在婴儿气味和车辆对照组之间，皮质醇水平没有显著差异。这些数据表明，雄性绒猴对婴儿的刺激有反应，气味刺激是在雄性绒猴的大脑中处理的。这项研究使用了WNPRC动物服务中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate brain pathways involved in mate affiliation and parental motivation. Functional magnetic resonance imaging (fMRI) is carried out on awake male marmosets while they are presented with isolated scents from (familiar vs. unfamiliar) adult females and infants. We have developed methods to present the olfactory stimuli to the male marmosets from both female scents (Ziegler et al., 2005) and from infant scents. Seven male marmosets were presented with scents from their own infants during a 10-minute presentation while the males were in isolation. Males were bled 30 minutes after the onset of the presentation and serum was analyzed for testostereone and cortisol. In a crossover design, males were presented with either their own infants' scents or a vehicle control scent. Males showed a significant decrease in testosterone levels after interacting with the infant scent whereas testosterone following presentation of the control stimulus did not alter from normal testosterone levels for male adult marmosets. Cortisol levels were not significantly different between the infant scent and the vehicle control. These data indicate that male marmosets are responsive to infant stimuli and that the scent stimuli are processed in the brains of the males. This research used WNPRC Animal Services.