BRAIN FUNCTION IN SOCIAL AFFILIATION AND PARENTAL MOTIVATION

社会归属和父母动机中的大脑功能

• 批准号: 7716450
• 负责人: Craig F Ferris
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716450
• 关键词: Adult; Animals; Brain; Callithrix; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Data; Female; Functional Magnetic Resonance Imaging; Funding; Grant; Hemorrhage; Hydrocortisone; Infant; Institution; Methods; Motivation; Partner in relationship; Research; Research Personnel; Resources; Serum; Services; Source; Stimulus; Testosterone; United States National Institutes of Health; awake; brain pathway; male; olfactory stimulus; social; stimulus processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate brain pathways involved in mate affiliation and parental motivation. Functional magnetic resonance imaging (fMRI) is carried out on awake male marmosets while they are presented with isolated scents from (familiar vs. unfamiliar) adult females and infants. We have developed methods to present the olfactory stimuli to the male marmosets from both female scents (Ziegler et al., 2005) and from infant scents. Seven male marmosets were presented with scents from their own infants during a 10-minute presentation while the males were in isolation. Males were bled 30 minutes after the onset of the presentation and serum was analyzed for testostereone and cortisol. In a crossover design, males were presented with either their own infants' scents or a vehicle control scent. Males showed a significant decrease in testosterone levels after interacting with the infant scent whereas testosterone following presentation of the control stimulus did not alter from normal testosterone levels for male adult marmosets. Cortisol levels were not significantly different between the infant scent and the vehicle control. These data indicate that male marmosets are responsive to infant stimuli and that the scent stimuli are processed in the brains of the males. This research used WNPRC Animal Services.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究配偶归属和父母动机的脑通路。 功能性磁共振成像（fMRI）是在清醒的雄性绒猴身上进行的，同时它们被提供了来自（熟悉的与不熟悉的）成年雌性和婴儿的孤立气味。 我们已经开发了从两种雌性气味向雄性绒猴呈现嗅觉刺激的方法（齐格勒等人，2005年，从婴儿的气味。 在10分钟的展示过程中，7只雄性绒猴被展示了它们自己婴儿的气味，而雄性绒猴被隔离。 雄性动物在发病后30分钟流血的，并分析血清中的睾酮和皮质醇。 在一个交叉设计中，雄性被给予它们自己的婴儿气味或载体对照气味。 男性表现出显着下降的睾丸激素水平后，与婴儿的气味，而睾丸激素的控制刺激的介绍后，没有改变从正常的雄性成年绒猴的睾丸激素水平。 皮质醇水平在婴儿气味和载体对照之间没有显著差异。 这些数据表明，雄性绒猴对婴儿刺激有反应，并且气味刺激在雄性的大脑中进行处理。这项研究使用WNPRC动物服务。