BRAIN FUNCTION IN SOCIAL AFFILIATION AND PARENTAL MOTIVATION

社会归属和父母动机中的大脑功能

• 批准号: 7958774
• 负责人: Craig F Ferris
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958774
• 关键词: Adult; Animals; Blood; Body Temperature; Brain; Callithrix; Computer Retrieval of Information on Scientific Projects Database; Data; Equipment; Female; Fiber Optics; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Grant; Hormones; IACUC; Infant; Institution; Monitor; Motivation; Partner in relationship; Primates; Publications; Reporting; Research; Research Personnel; Resources; Services; Site; Source; Technology; Temperature; United States National Institutes of Health; Wisconsin; Work; awake; brain pathway; male; medical schools; sensor; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate brain pathways involved in mate affiliation and parental motivation. Functional magnetic resonance imaging (fMRI) is carried out on awake male marmosets while being presented with isolated scents from (familiar vs. unfamiliar) adult females and infants. Specific hormones in the blood and CSF are used to correlate brain responsiveness with hormone levels. These were initial studies to determine if the magnet facilities at Medical College of Wisconsin would prove a useful Midwest site for the WNPRC marmosets. In addition, pilot data was collected for mate affiliation and parental motivation. There were some problems with the technology that caused increased body temperature in the marmosets during functional imaging. We have worked out the technology issue and now have a temperature controller (ability to increase or reduce the body temperature as needed), fiber-optic sensor, and other magnet compatible monitoring equipment. We are working on getting IACUC approval to continue these studies. This research used WNPRC Animal Services. Funding ended before this reporting period. A publication has resulted.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：研究伴侣隶属关系和父母动机涉及的大脑通路。 功能性磁共振成像（fMRI）是在清醒的雄性果蝇上进行的，同时呈现出（熟悉与陌生）成年女性和婴儿的孤立气味。 血液和CSF中的特定激素用于将脑反应能力与激素水平相关联。这些是最初的研究，以确定威斯康星州医学院的磁铁设施是否会证明是WNPRC Marmosets的有用地点。此外，还收集了试点数据以进行伴侣的隶属关系和父母的动机。在功能成像过程中，该技术导致果果会的体温升高存在一些问题。我们已经解决了技术问题，现在有一个温度控制器（能够根据需要升高或降低体温），光纤传感器和其他兼容监测设备。我们正在努力获得IACUC批准，以继续这些研究。这项研究使用了WNPRC动物服务。 资金在此报告期之前结束。产生了出版物。