BRAIN FUNCTION IN SOCIAL AFFILIATION AND PARENTAL MOTIVATION

社会归属和父母动机中的大脑功能

• 批准号: 7958774
• 负责人: Craig F Ferris
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958774
• 关键词: Adult; Animals; Blood; Body Temperature; Brain; Callithrix; Computer Retrieval of Information on Scientific Projects Database; Data; Equipment; Female; Fiber Optics; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Grant; Hormones; IACUC; Infant; Institution; Monitor; Motivation; Partner in relationship; Primates; Publications; Reporting; Research; Research Personnel; Resources; Services; Site; Source; Technology; Temperature; United States National Institutes of Health; Wisconsin; Work; awake; brain pathway; male; medical schools; sensor; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate brain pathways involved in mate affiliation and parental motivation. Functional magnetic resonance imaging (fMRI) is carried out on awake male marmosets while being presented with isolated scents from (familiar vs. unfamiliar) adult females and infants. Specific hormones in the blood and CSF are used to correlate brain responsiveness with hormone levels. These were initial studies to determine if the magnet facilities at Medical College of Wisconsin would prove a useful Midwest site for the WNPRC marmosets. In addition, pilot data was collected for mate affiliation and parental motivation. There were some problems with the technology that caused increased body temperature in the marmosets during functional imaging. We have worked out the technology issue and now have a temperature controller (ability to increase or reduce the body temperature as needed), fiber-optic sensor, and other magnet compatible monitoring equipment. We are working on getting IACUC approval to continue these studies. This research used WNPRC Animal Services. Funding ended before this reporting period. A publication has resulted.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：研究涉及配偶归属和父母动机的大脑通路。 功能性磁共振成像（fMRI）是在清醒的雄性狨猴身上进行的，同时呈现来自（熟悉与不熟悉）成年雌性和婴儿的孤立气味。 血液和脑脊液中的特定激素用于将大脑反应性与激素水平相关联。这些是初步研究，旨在确定威斯康星医学院的磁铁设施是否会成为 WNPRC 狨猴在中西部的有用地点。此外，还收集了有关配偶关系和父母动机的试点数据。该技术存在一些问题，导致狨猴在功能成像过程中体温升高。我们已经解决了技术问题，现在拥有温度控制器（能够根据需要升高或降低体温）、光纤传感器和其他磁铁兼容的监控设备。我们正在努力获得 IACUC 的批准以继续这些研究。这项研究使用了 WNPRC 动物服务中心。 资金在本报告期之前结束。结果已出版。