Administration

行政

• 批准号: 8181944
• 负责人: Lynn Hlatky
• 金额: $ 104.96万
• 依托单位: STEWARD ST. ELIZABETH'S MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181944
• 关键词: Academic Training; Appointment; Arts; Back; Background Radiation; Biological; Cancer Biology; Cancer Center; Cancer Model; Clinical; Clinical Services; Country; Databases; Development; Environment; Event; Faculty; Funding; Goals; Grant; Investments; Laboratory Research; Letters; Low Dose Radiation; Malignant Neoplasms; Medical Oncology; Medical center; Medicine; Modeling; Molecular; Program Research Project Grants; Research; Research Personnel; Research Training; Resources; Risk; Running; Schools; Solid Neoplasm; Specialized Center; System; Systems Biology; Training; United States National Aeronautics and Space Administration; anticancer research; carcinogenesis; multidisciplinary; oncology; programs; research facility; square foot

The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and fissue-level events underlying cancer evolufion and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and mulfidisciplinary cancer group which it is becoming an internafionally competifive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathemafical and computafional modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million; PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP applicafion would provide an opportunity to connect this established CCSB with the nafional networks of ICBP-funded Centers around the country also embarking on predicfive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruifing Dr. HIatky as director, and the dedicafion of laboratory research space and compufing resources, as well as the subsequent expansion of her group, represents a major insfitufional investment and confinuing commitment to innovafive, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an addifional 8,000 sq ft for Rad One and an addifional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The confinuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.

癌症系统生物学中心（CCSB）圣伊丽莎白医疗中心，塔夫茨大学医学院 （TUSM），从生物学，数学，物理和临床上汇集了不同的研究人员 背景可以更好地了解癌症演变的分子和触发级事件 发展。自成立以来的三年中，CCSB已成熟成一个良好的，深厚的 互动和含实的学科癌症小组正在成为一项国内竞争性的研究 癌症系统生物学簇的培训设施和研究数据存储库CCSB已经是 两个联邦政府资助的多学科计划项目授予致癌的接受者。每个 将数学和计算机模型与最先进的实验性癌症生物学结合在一起。这 首先是用于研究实体瘤致癌风险的NASA专业研究中心（NSCOR） 从太空透明接触（1000万美元； Pi Dr. Hiatky）。第二个是由母鹿资助的中心学习 低剂量辐射从背景辐射暴露后的癌变风险（对博士的750万美元 Hiatky和Hahnfeldt博士为此问题进行数学分析。显然，PI和 中心非常精心运行有关致癌作用的大型计划补助。此ICBP应用程序的资金 将提供一个机会，将此已建立的CCSB与ICBP资助的Nafional网络联系起来 全国各地还开始进行预性癌症建模，从而为NCI做出了贡献 该计划的直接目标。 TUSM SEMC医学总监Nicolaos Madias医学博士进行了故意 建立CCSB的战略决策，招募Hiatky博士担任董事，并专门 实验室研究空间和资源以及随后的小组扩张， 代表了对创新，袖口癌症的主要投资和牢固的承诺 研究。 SEMC通过大规模扩展计划支持了这项研究承诺 在肿瘤学中心为其临床服务实施 以及用于医学肿瘤学的8,000平方英尺（请参阅Madias博士支持信）。广度和深度 SEMC对这一长期战略目标的承诺很明确。限制的力量 智力，学术和培训环境由研究教师以及临床培训加强 通过TUSM约会。