Administration

行政

• 批准号: 8181944
• 负责人: Lynn Hlatky
• 金额: $ 104.96万
• 依托单位: STEWARD ST. ELIZABETH'S MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181944
• 关键词: Academic Training; Appointment; Arts; Back; Background Radiation; Biological; Cancer Biology; Cancer Center; Cancer Model; Clinical; Clinical Services; Country; Databases; Development; Environment; Event; Faculty; Funding; Goals; Grant; Investments; Laboratory Research; Letters; Low Dose Radiation; Malignant Neoplasms; Medical Oncology; Medical center; Medicine; Modeling; Molecular; Program Research Project Grants; Research; Research Personnel; Research Training; Resources; Risk; Running; Schools; Solid Neoplasm; Specialized Center; System; Systems Biology; Training; United States National Aeronautics and Space Administration; anticancer research; carcinogenesis; multidisciplinary; oncology; programs; research facility; square foot

The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and fissue-level events underlying cancer evolufion and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and mulfidisciplinary cancer group which it is becoming an internafionally competifive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathemafical and computafional modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million; PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP applicafion would provide an opportunity to connect this established CCSB with the nafional networks of ICBP-funded Centers around the country also embarking on predicfive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruifing Dr. HIatky as director, and the dedicafion of laboratory research space and compufing resources, as well as the subsequent expansion of her group, represents a major insfitufional investment and confinuing commitment to innovafive, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an addifional 8,000 sq ft for Rad One and an addifional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The confinuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.

癌症系统生物学中心（CCSB）塔夫茨大学医学院圣伊丽莎白医学中心 （TUSM），汇集了来自生物，数学，物理和临床的不同研究人员 为了更好地理解癌症演变的分子和裂隙水平事件， 发展在成立三年来，CCSB已经发展成为一个成熟的，深入的 它正在成为一个具有国际竞争力的研究 癌症系统生物学的培训设施和研究数据存储库塔夫茨CCSB已经 两个联邦资助的多学科项目项目赠款的收件人致癌。每个 结合了物理和计算建模与最先进的实验癌症生物学。的 首先是NASA专业研究中心（NSCOR），资助研究实体瘤致癌风险 来自太空辐射暴露（1000万美元; PI博士HIatky）。第二个是能源部资助的研究中心 致癌风险后，低剂量辐射暴露于本底辐射（750万美元，博士。 HIatky和100万Hahnfeldt博士对这个问题的数学分析）。显然，PI和 中心精通运行大型项目赠款致癌。ICBP申请的资金来源 将提供一个机会，将这个已建立的CCSB与ICBP资助的国家网络连接起来， 全国各地的中心也开始进行预测癌症建模，从而为NCI做出贡献。 本计划的目标。Nicolaos Madias，医学博士，医学总监，SEMC，TUSM故意 建立CCSB的战略决策，聘请HIatky博士担任主任，以及 实验室研究空间和计算资源，以及随后她的小组的扩大， 代表了一项重大的投资和承诺，以创新，袖口边缘癌症 research. SEMC支持这一研究承诺，并制定了一项大规模的扩展计划， 在肿瘤中心的临床服务中实施，涉及额外的8，000平方英尺的Rad One 另外还有8，000平方英尺用于肿瘤内科（请参阅支持信Madias博士）。广度和深度 SEMC对这一长期战略目标的承诺是明确的。的约束力， 智力，学术和培训环境是由研究人员以及临床培训加强 通过TUSM预约。