EVALUATION OF RANTES ANALOGUES FOR PROTECTION FROM SHIV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 迫切需要有效的艾滋病毒预防战略，但最近关键疫苗和“杀微生物剂”临床试验的失败突显了在相关动物模型中验证新方法的必要性。在这里，我们展示了两种新的趋化因子(C-C基序)受体5抑制剂，5P12-RANTES(受激活调节，正常T细胞表达和分泌)和6P4-RANTES，在恒河猴阴道攻击模型中完全保护免受感染。这些高效分子易于低成本生产，代表着杀菌剂流水线上有希望的新成员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Effective strategies for HIV prevention are urgently needed, but recent failures in key vaccine and 'microbicide' clinical trials highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.