Finding solutions to alleviate gastrointestinal health in dairy cows and calves

寻找缓解奶牛和犊牛胃肠健康的解决方案

• 批准号: 570914-2021
• 负责人: Steele, MichaelM
• 金额: $ 9.69万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=743544
• 关键词: Finding; solutions; alleviate; gastrointestinal; health

The Canadian dairy industry contributes almost $20 billion to the gross domestic product, constituting one of the country's largest agricultural sectors. Given its contribution and significance, it is critical that the dairy industry find solutions to issues that jeopardize animal health, welfare, and productivity. One common concern among periparturient dairy cows and preweaning calves is increased gastrointestinal (GIT) barrier dysfunction and inflammation, associated with high morbidity and decreased productivity, negatively impacting animal welfare and farm profitability. Probiotics have been successfully used to treat and prevent GIT-related disorders in humans. In monogastric animals, supplementation of the probiotic yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 (SCB) has been shown to modulate GIT permeability, microbiota, and immune response of immune-compromised subjects, effectively improving GIT function, health, and productivity. Previous studies evaluating yeast supplementation in dairy cows focused mainly on feed intake, digestibility of feeds, and production responses in established lactation. However, there is a paucity of studies assessing the effects of SCB on GIT permeability and inflammation of periparturient cows and preweaning calves. Therefore, the overall objective of this research project is to evaluate SCB supplementation as an innovative solution to alleviate GIT barrier dysfunction and inflammation during the transition and preweaning periods of dairy cows and calves. The outcomes of this research will determine the efficacy of a nonantimicrobial alternative to enhance the health, welfare, and performance of dairy cows and preweaning calves. As such, this proposal will reduce the dairy industry's reliance on antimicrobial treatments, thus aligning with the market and consumer demands to improve animal health, welfare, and food safety.

加拿大乳制品业为国内生产总值贡献了近 200 亿加元，是该国最大的农业部门之一。鉴于其贡献和重要性，乳制品行业找到解决危害动物健康、福利和生产力问题的解决方案至关重要。围产期奶牛和断奶前犊牛普遍担心的一个问题是胃肠道 (GIT) 屏障功能障碍和炎症增加，这与高发病率和生产力下降有关，对动物福利和农场盈利能力产生负面影响。益生菌已成功用于治疗和预防人类胃肠道相关疾病。在单胃动物中，补充益生菌酿酒酵母变种。 boulardii CNCM I-1079 (SCB) 已被证明可以调节免疫受损受试者的胃肠道通透性、微生物群和免疫反应，有效改善胃肠道功能、健康和生产力。之前评估奶牛酵母补充量的研究主要集中在采食量、饲料消化率以及泌乳期的生产反应。然而，很少有研究评估 SCB 对围产期奶牛和断奶前犊牛胃肠道通透性和炎症的影响。因此，该研究项目的总体目标是评估 SCB 补充剂作为一种创新解决方案，以缓解奶牛和犊牛在过渡期和断奶前期的胃肠道屏障功能障碍和炎症。这项研究的结果将确定非抗生素替代品在增强奶牛和断奶前犊牛的健康、福利和生产性能方面的功效。因此，该提案将减少乳制品行业对抗菌治疗的依赖，从而符合市场和消费者改善动物健康、福利和食品安全的需求。