COMPARTMENTAL ANALYSIS OF PROTEOMIC BIOMARKERS DURING INTRA-UTERINE INFECTIONS

子宫内感染期间蛋白质组生物标志物的区室分析

• 批准号: 8173276
• 负责人: Peta Louise Grigsby
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173276
• 关键词: ANXA2 gene; Biological Markers; Characteristics; Clinical Management; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Early Diagnosis; Endocrine; Experimental Models; Funding; Grant; Homeostasis; Infection; Institution; Insulin-Like Growth-Factor Binding Protein 1; Intervention; Modeling; Molecular Profiling; Physiological Adaptation; Placental Circulation; Premature Birth; Proteomics; Research; Research Personnel; Resources; Risk; Source; Staging; Therapeutic; United States National Institutes of Health; Ureaplasma urealyticum biovar 1; Woman; Work; career development; expectation; fetal; hemodynamics; improved; intraamniotic infection; nonhuman primate; respiratory

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research and career development grant are to utilize a nonhuman primate experimental model of intra-uterine infection with Ureaplasma parvum to characterize the temporal and mechanistic interactions among biomarker expression profiles (i.e., IGFBP-1 proteolytic fragments, calgranulins A and B and annexin II), in maternal and fetal compartments at defined stages of ascending uterine infection (from choriodecidual to intra-amniotic models). It is our hypothesis that specific biomarker profiles (spatial and temporal characteristics), will serve as surrogates for the stage of progression of ascending intra-uterine infection. An important aspect of this study is to determine the fetal physiologic adaptations to intra-amniotic infection (i.e., endocrine status, respiratory parameters and hemodynamic changes in regional and placental circulations), and to assess the efficacy of a combined therapeutic approach for improving fetal cardio-respiratory homeostasis. The work proposed is unique in its combined use of diagnostic and interventional strategies in a nonhuman primate model of intra-uterine infection (experimental choriodecidual and intra-amniotic stages). It is our expectation that the results of these studies will advance clinical management and facilitate the early diagnosis of women that are at risk for preterm delivery as a consequence of intra-uterine infection.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究和职业发展的目的是利用尿素内感染的非​​人类灵长类动物 - 田内感染模型，以表征生物标志物表达曲线之间的时间和机械相互作用，即IGFBP-1蛋白水解蛋白质片段，Calgranuline a和b and b and b and by n and commental in compention in compention and commental in Maternalne in Maternalne in Maternalne in Maternalne in Maternalne in Malternal in Malternal in Malternal in Maternalne in Maternalne in Malternal in Maternaln （从脉络膜上到散布模型）。我们的假设是，特定的生物标志物谱（空间和时间特征）将成为上升 - 局内感染阶段的替代物。这项研究的一个重要方面是确定胎儿生理学适应对肿瘤内感染的适应性（即内分泌状态，呼吸参数和区域和胎盘循环中的血液动力学变化），并评估一种综合治疗方法来改善胎儿性辅助性呼吸性稳态的疗效。提出的工作是在非人类的uterine肾上腺内感染模型（实验性脉络化脉络化和散布阶段）中的诊断和介入策略的联合使用。我们期望这些研究的结果将提高临床管理，并促进因局内感染而受到早产风险的妇女的早期诊断。