UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

子宫内脲原体感染：预防神经系统后遗症

• 批准号: 8357809
• 负责人: Peta Louise Grigsby
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357809
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Caring; Cerebrum; Critical Care; Encephalitis; Funding; Genital system; Grant; Infant Care; Inflammation; Intake; Liquid substance; Macaca mulatta; Medical; Mycoplasma; National Center for Research Resources; Neonatal; Neurologic; Neuronal Injury; Newborn Infant; Nurseries; Oxygen; Premature Birth; Prevention; Primates; Principal Investigator; Procedures; Protocols documentation; Research; Research Infrastructure; Research Proposals; Resources; Source; United States National Institutes of Health; Ureaplasma Infections; Veterinarians; cost; fetal; in utero; intraamniotic infection; neurobehavioral; postnatal; prenatal; respiratory; white matter; white matter injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this research proposal are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies, it is necessary to expand the scope of newborn infant care at the ONPRC by establishing a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we developed critical care management plans (i.e., respiratory support, supplemental oxygen, i.v fluids and intakes), as well as standard operating procedures to assure optimal chance of neonatal survival.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项研究的目的是描述生殖器支原体引起的大脑白色物质炎症和神经元损伤的程度（U。parvum），并评估母体抗生素加抗炎治疗在改善胎儿脑炎症和神经元损伤中的功效。我们的假设是，产前治疗U。使用特定抗生素和适当的抗炎剂治疗细小羊膜腔感染（IAI）将延迟早产并减轻新生儿脑白色物质损伤的胎儿起源。为了促进我们的研究，有必要扩大ONPRC新生儿护理的范围，建立一个特殊护理托儿所（SCN），将支持早产恒河猴的产后生存和特定的神经行为评估协议，研究产后神经后遗症。在合作学术兽医和ONPRC兽医的医学指导下，我们制定了重症监护管理计划（即，呼吸支持、补充氧气、静脉输液和摄入）以及标准操作程序，以确保新生儿存活的最佳机会。