UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本研究的目的是描述生殖器支原体引起的脑白质炎症和神经元损伤的程度，并评估母体抗生素加抗炎治疗在改善胎儿脑部炎症和神经元损伤方面的疗效。我们的假设是，产前使用特定的抗生素和适当的抗炎药治疗微小葡萄球菌羊膜内感染(IAI)将延迟早产，并减轻新生儿脑白质损伤的胎儿起源。为了方便我们的研究，有必要扩大ONPRC的新生儿护理范围，建立一个特殊护理托儿所(SCN)，支持早产猕猴的出生后存活，并制定具体的神经行为评估方案，以研究出生后神经后遗症。在学术新生儿专家和ONPRC兽医的医学指导下，我们制定了重症监护管理计划(即呼吸支持、补充氧气、静脉输液和摄入量)以及标准操作程序，以确保新生儿存活的最佳机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this research proposal are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies, it is necessary to expand the scope of newborn infant care at the ONPRC by establishing a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we developed critical care management plans (i.e., respiratory support, supplemental oxygen, i.v fluids and intakes), as well as standard operating procedures to assure optimal chance of neonatal survival.