UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

子宫内脲原体感染：预防神经系统后遗症

• 批准号: 8173301
• 负责人: Peta Louise Grigsby
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173301
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Caring; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Critical Care; Encephalitis; Funding; Genital system; Grant; Inflammation; Institution; Macaca mulatta; Medical; Mycoplasma; Neonatal; Neurologic; Neuronal Injury; Nurseries; Premature Birth; Prevention; Procedures; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Ureaplasma Infections; Veterinarians; fetal; in utero; intraamniotic infection; neurobehavioral; postnatal; prenatal; white matter; white matter injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies we will establish a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we will develop critical care management plans, as well as standard operating procedures neonatal care.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是描述生殖器支原体引起的脑白质炎症和神经元损伤的程度，并评估母体抗生素加抗炎治疗在改善胎儿脑部炎症和神经元损伤方面的疗效。我们的假设是，产前使用特定的抗生素和适当的抗炎药治疗微小葡萄球菌羊膜内感染(IAI)将延迟早产，并减轻新生儿脑白质损伤的胎儿起源。为了方便我们的研究，我们将建立一个特别护理托儿所(SCN)来支持早产恒河猴的出生后存活，并建立专门的神经行为评估方案来研究出生后神经后遗症。在学术新生儿专家和ONPRC兽医的共同指导下，我们将制定危重护理管理计划，以及标准的新生儿护理操作程序。