Research Methods Core

关于认知行为疗法（CBT）对焦虑青年的改变机制知之甚少， 这可能是因为大多数治疗结果研究仅关注诊断状态的变化， 症状，而不是使用多方法方法来了解跨多个系统的更改 与复苏有关。这一核心将采用跨学科方法，为以下方面提供一个综合结构： 检查症状的变化，在家庭和同伴环境中的行为，睡眠和大脑反应， 焦虑儿童在认知行为治疗前后的认知和情绪信息加工任务 还有CCT这些数据将用作所有三个主要项目的分析基础。 具体而言，该核心描述了以下评估。治疗前后，参与者将 使用评分法对临床状态、症状、情感风格和亲子互动进行完整测量 量表、自我报告测量和行为观察。还将收集基因数据。参与者 将在功能磁共振成像和并行瞳孔期间完成认知和情感信息处理测量 扩张/眼动追踪评估，以及事件相关电位（ERP）评估。每两周 在整个治疗过程中，参与者将完成自我报告的口腔病学，学生， 扩张/眼动跟踪评估，以及基于家庭的生态瞬时评估和睡眠 腕动记录方案。这一核心整合并监督所有项目的评估方法。的 特别重要的是，提供了用于为每个主要数据创建复合摘要索引的方法， 评估领域，用于每个项目和跨项目分析，通过核心 3. 将这些方法集中在一个单一的核心中，有一个单一的项目协调员， 测量方法对于这种CIDAR机制至关重要。集中管理这些 评估将1）有助于更好地理解这些评估如何结合在一起，2）促进 以后整合项目间的分析和结果，3）提高效率，减少参与者 通过以方便和有计划的方式整合评估来减轻负担。

Little is known about the mechanisms of change in cognitive behavioral therapy (CBT) for anxious youth, potentially because most treatment outcome studies have focused only on changes in diagnostic status and symptoms, rather than using a multi-method approach to understand changes across multiple systems associated with recovery. Using a transdisciplinary approach, this core will provide an integrated structure for examining changes in symptoms, behavior in family and peer contexts, sleep, and brain reactivity to cognitive and emotional information processing tasks among anxious children before, during, and after CBT and CCT. These data will be used as the basis for analyses across all three of the primary projects. Specifically, this core describes the following assessments. Before and after treatment, participants will complete measures of clinical status, symptoms, affective style, and parent-child interactions using rating scales, self-report measures, and behavioral observations. Genetic data will also be acquired. Participants will complete cognitive and affective information processing measures during fMRI and concurrent pupil dilation/eyetracking assessment, as well as event-related potential (ERP) assessment. On a biweekly basis throughout treatment, participants will complete self-report ratings of symptomatology, pupil dilation/eyetracking assessments, and a home based Ecological Momentary Assessment and sleep actigraphy protocol. This core integrates and oversees the assessment methodologies for all projects. Of particular importance, methods are provided for creating composite summary indices for each primary domain of assessment, for use in each project and in cross-project analyses, via methods developed in Core 3. Having these methods centralized in a single core, with a single project coordinator, and an integrative measurement approach is essential for this CIDAR mechanism. Centralizing the administration of these assessments will 1) contribute to a better understanding of how these assessments fit together, 2) facilitate later integration of analyses and results across projects, and 3) increase efficiency and decrease participant burden by integrating assessments in a convenient and planful manner.