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Graduated sensory salience as an intervention for intrusive negative thinking

分级感官显着性作为侵入性消极思维的干预措施

基本信息

批准号：
9337053
负责人：
GREG J SIEGLE
金额：
$ 32.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9337053
关键词：
Acute Affect Anxiety Attention Behavioral Biological Brain Clinical Cognition Cognitive Crying Depressed mood Dimensions Discipline Educational Intervention Electroencephalography Elements Emotional Esthesia Evaluation Feedback Functional Magnetic Resonance Imaging Goals Individual Intervention Lip structure Measures Mental Depression Mental disorders Mind Modernization Moods Outcome Pain Parietal Participant Pathway interactions Patient Self-Report Patients Pharmacology Phase Placebos Positioning Attribute Pruritus Psychometrics Psychopathology Psychotherapy Randomized Controlled Trials Recording of previous events Resistance Sensory Stimulus Suicide Symptoms System Techniques Thinking Training Trauma Treatment outcome Volition Work Yang chronic pain cognitive control cognitive task cognitive training directed attention dysphoria emotion regulation emotional stimulus improved indexing midbrain central gray substance neurobehavioral neuroimaging novel post intervention prognostic psychologic recruit relating to nervous system response retinal rods sensory stimulus somatosensory success sustained attention

项目摘要

DESCRIPTION (provided by applicant): Intrusive negative cognitions are key transdiagnostic features of many psychiatric disorders, are difficult to treat, and predict poor outcomes in conventional and neurobehavioral interventions. Here, we evaluate the extent to which a novel intervention capitalizing on a preserved neurocircuitry for attending to evolutionarily salient somatosensory stimuli can be used to train attentional mechanisms to override otherwise pre-potent negative cognitions. The R21 period will involve intervention refinement and mechanistic evaluation of mechanism; N=35 individuals with high levels of intrusive negative cognitions and dysphoria will be assessed pre/post intervention. The R33 phase will involve mechanistic comparison to control conditions and psychometric evaluation; N=60 individuals with high levels of intrusive negative cognitions and associated dysphoria will undergo either an active intervention involving directed attention to graduated decreasing degrees of physical sensation (N=40) or a non-graduated control condition (N=40). Mechanisms of attentional focus on non-emotional and emotional stimuli will be assessed via neuroimaging in these individuals before and after the intervention along with 20 healthy control participants who will be assessed a twice. Success will suggest a new intervention pathway for a traditionally treatment-resistant dimension of psychopathology.