Murine Models for Studying Human Colon Cancer

描述（由申请人提供）：结直肠癌是美国癌症死亡的第二大原因。 1995年，大约有16万例结直肠癌新发病例，6万人因此死亡。了解该疾病的病因和改进治疗的要求之一是开发新的动物模型，在其中可以研究正常组织生物学和癌发生的所有阶段。这些工具已经到位，可以为癌症研究准备新的小鼠模型；基础研究人员和临床研究人员之间需要就人类肿瘤的分子生物学、肿瘤的发生和进展与生物相关性以及小鼠和大鼠的建模进行持续对话。为此，本申请中提议的会议将于 2010 年 10 月 19-22 日由位于缅因州巴港的杰克逊实验室主办。我们设计这次会议的目的不是安排一系列讲座，而是在半天的会议中解决六组当前问题：1) 易感性/耐药性遗传因素和 GWAS，2) 干细胞和祖细胞； （多）克隆性；培养隐窝和上皮细胞，3) 基因组稳定性（CIN 和 MIN）和表观遗传因素（CIMP）：多途径假说；体细胞突变和表观突变；用于诊断和预后的生物标志物；锯齿状肿瘤、鳞状肿瘤和直肠肿瘤；纵向研究，4）发育不良；急救人员；极性; (a)对称细胞分裂；进展，5）炎症和环境危险因素；肠道菌群；化学预防，6) 早期发现；治疗目标。每届会议将由一名现任报告员主持。我们打算将半天的课程安排在上午（9 - 12:30）和下午（2:30 - 6:00），每次有 30 分钟的休息时间。每场会议通常有两次 20 分钟的演讲和六次 10 分钟的演讲，每次演讲后有 5 分钟的讨论时间。报告员将在每半天的会议开始时提供 10 分钟的介绍，并在每次半天会议结束时主持 10 分钟的一般性讨论。我们相信，结肠癌的研究领域正在达到一个令人兴奋的阶段，值得召开一次由高级和初级研究人员参加的互动会议。此外，巴港的环境将为此类会议提供一个蓬勃发展的场所，这与城市环境中的大型会议形成鲜明对比，在城市环境中，演讲者进行演讲，然后只与预先确定的同事会面。 公共卫生相关性：结肠癌仍然是当今美国主要的健康威胁之一。为了实现有效的人类癌症模型的开发，基础研究人员和临床研究人员保持清晰的沟通渠道至关重要，以促进双方对动物模型中的疾病及其表型以及如何将其转化为人类疾病的研究和治疗的全面了解。 ）

DESCRIPTION (provided by applicant): Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a continuing dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in mice and rats. To this end, the meeting proposed in this application will be hosted by The Jackson Laboratory in Bar Harbor Maine on October 19-22, 2010. Rather than scheduling a series of lectures, we are designing this conference to address six sets of current issues in half-day sessions: 1) Susceptibility/resistance genetic factors and GWAS, 2) Stem and progenitor cells; (poly)clonality; culturing crypts and epithelia, 3) Genomic (in)stability (CIN and MIN) and epigenetic factors (CIMP): The multiple pathway hypothesis; somatic mutations and epimutations; biomarkers for diagnosis and prognosis; serrated, squamous, and rectal tumors; longitudinal studies, 4) Dysplasia; EMT; polarity; (a)symmetric cell division; progression, 5) Inflammation and environmental risk factors; intestinal flora; chemoprevention, and 6) Early detection; therapeutic targets. Each Session will be chaired by an active Rapporteur. We intend to schedule the half-day sessions for morning (9 - 12:30) and afternoon (2:30 - 6:00), each with a 30- minute break. Each session will typically have two 20-minute talks and six 10-minute talks, with five minutes for discussion after each talk. The Rapporteur will provide 10 minutes of introduction at the beginning and lead 10 minutes of general discussion at the end of each half-day session. We believe that the field of research on colon cancer is reaching an exciting point, one that deserves an interactive conference involving both senior and junior investigators. Furthermore, the setting in Bar Harbor will provide a venue in which this sort of conference can thrive, in contrast to larger conferences in urban settings where speakers give lectures and then meet only with pre-determined colleagues. PUBLIC HEALTH RELEVANCE: Colon cancer remains one of the leading health threats in the U.S. today. In order to realize the development of effective models of human cancer, it is critical that basic and clinical researchers maintain clear lines of communication that promote a complete bilateral understanding of the disease and its phenotypes in animal models and how this translates to the study and treatment of the human disease. )