Murine Models for Studying Human Colon Cancer

用于研究人类结肠癌的小鼠模型

• 批准号: 8124042
• 负责人: RICHARD P WOYCHIK
• 金额: $ 0.9万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-10 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8124042
• 关键词: Address; Animal Model; Bilateral; Biological; Biological Markers; Biology; Cancer Etiology; Cell division; Cessation of life; Chemoprevention; Clinical; Clonality; Colon Carcinoma; Colorectal Cancer; Communication; CpG Island Methylator Phenotype; Development; Diagnosis; Disease; Dysplasia; Early Diagnosis; Environmental Risk Factor; Epigenetic Process; Epithelium; Etiology; Genetic; Genomics; Health; Human; Inflammation; Intestines; Laboratories; Lead; Longitudinal Studies; Maine; Malignant Neoplasms; Modeling; Molecular Biology; Mus; Normal tissue morphology; Pathway interactions; Phenotype; Predisposition; Public Health; Rattus; Rectal Tumors; Research; Research Personnel; Resistance; Schedule; Series; Somatic Mutation; Sorting - Cell Movement; Staging; Stem cells; Study models; Translating; United States; anticancer research; carcinogenesis; design; genome wide association study; human disease; improved; lectures; meetings; mouse model; outcome forecast; public health relevance; stem; symposium; therapeutic target; tool; tumor

DESCRIPTION (provided by applicant): Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a continuing dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in mice and rats. To this end, the meeting proposed in this application will be hosted by The Jackson Laboratory in Bar Harbor Maine on October 19-22, 2010. Rather than scheduling a series of lectures, we are designing this conference to address six sets of current issues in half-day sessions: 1) Susceptibility/resistance genetic factors and GWAS, 2) Stem and progenitor cells; (poly)clonality; culturing crypts and epithelia, 3) Genomic (in)stability (CIN and MIN) and epigenetic factors (CIMP): The multiple pathway hypothesis; somatic mutations and epimutations; biomarkers for diagnosis and prognosis; serrated, squamous, and rectal tumors; longitudinal studies, 4) Dysplasia; EMT; polarity; (a)symmetric cell division; progression, 5) Inflammation and environmental risk factors; intestinal flora; chemoprevention, and 6) Early detection; therapeutic targets. Each Session will be chaired by an active Rapporteur. We intend to schedule the half-day sessions for morning (9 - 12:30) and afternoon (2:30 - 6:00), each with a 30- minute break. Each session will typically have two 20-minute talks and six 10-minute talks, with five minutes for discussion after each talk. The Rapporteur will provide 10 minutes of introduction at the beginning and lead 10 minutes of general discussion at the end of each half-day session. We believe that the field of research on colon cancer is reaching an exciting point, one that deserves an interactive conference involving both senior and junior investigators. Furthermore, the setting in Bar Harbor will provide a venue in which this sort of conference can thrive, in contrast to larger conferences in urban settings where speakers give lectures and then meet only with pre-determined colleagues. PUBLIC HEALTH RELEVANCE: Colon cancer remains one of the leading health threats in the U.S. today. In order to realize the development of effective models of human cancer, it is critical that basic and clinical researchers maintain clear lines of communication that promote a complete bilateral understanding of the disease and its phenotypes in animal models and how this translates to the study and treatment of the human disease. )

描述(申请人提供)：结直肠癌是美国癌症死亡的第二大原因。1995年，大约有16万例新的结直肠癌病例，其中6万人死于这种疾病。在了解这种疾病的病因和改进治疗方面取得进展的要求之一是开发新的动物模型，在这种模型中可以研究正常的组织生物学和所有阶段的癌症发生。为癌症研究准备新的小鼠模型的工具已经到位；需要的是基础和临床研究人员之间关于人类肿瘤的分子生物学、它们的启动和进展与生物相关性以及在小鼠和大鼠中的建模的持续对话。为此，本申请中提议的会议将于2010年10月19日至22日在缅因州巴尔港由杰克逊实验室主办。我们没有安排一系列讲座，而是设计这次会议，在半天的会议中讨论六组当前的问题：1)易感/耐药遗传因素与GWA，2)干细胞和祖细胞；(多)克隆性；培养隐窝和上皮；3)基因组(In)稳定性(CIN和MIN)和表观遗传因素(CIMP)：多途径假说；体细胞突变和表观突变；诊断和预后的生物标记物；锯齿状、鳞状和直肠肿瘤；纵向研究，4)异型增生；EMT；极性；(A)对称细胞分裂；进展，5)炎症和环境风险因素；肠道菌群；化学预防和6)早期发现；治疗靶点。每届会议将由一名活跃的报告员主持。我们计划在上午(9-12：30)和下午(2：30-6：00)安排半天的会议，每个会议有30分钟的休息时间。每堂课通常有两次20分钟的演讲和6次10分钟的演讲，每次演讲后有5分钟的讨论时间。报告员将在每届半天会议开始时提供10分钟的介绍，并在每半天的会议结束时主持10分钟的一般性讨论。我们相信，结肠癌的研究领域正在达到一个激动人心的点，值得举行一次包括高级和初级研究人员在内的互动会议。此外，巴尔港的环境将为此类会议的蓬勃发展提供一个场所，与城市环境中的大型会议形成对比，在城市环境中，演讲者发表演讲，然后只与预先确定的同事会面。 与公共健康相关：结肠癌仍然是当今美国最大的健康威胁之一。为了实现有效的人类癌症模型的开发，至关重要的是基础和临床研究人员保持清晰的沟通渠道，以促进对疾病及其在动物模型中的表型的完整的双边理解，以及这如何转化为对人类疾病的研究和治疗。)