Murine Models for Studying Human Colon Cancer

用于研究人类结肠癌的小鼠模型

• 批准号: 8006104
• 负责人: RICHARD P WOYCHIK
• 金额: $ 1.2万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006104
• 关键词: Address; Animal Model; Bilateral; Biological; Biological Markers; Biology; Cancer Etiology; Cell division; Cessation of life; Chemoprevention; Clinical; Clonality; Colon Carcinoma; Colorectal Cancer; Communication; CpG Island Methylator Phenotype; Development; Diagnosis; Disease; Dysplasia; Early Diagnosis; Environmental Risk Factor; Epigenetic Process; Epithelium; Etiology; Genetic; Genomics; Health; Human; Inflammation; Intestines; Laboratories; Lead; Longitudinal Studies; Maine; Malignant Neoplasms; Modeling; Molecular Biology; Mus; Normal tissue morphology; Pathway interactions; Phenotype; Predisposition; Public Health; Rattus; Rectal Tumors; Research; Research Personnel; Resistance; Schedule; Series; Somatic Mutation; Sorting - Cell Movement; Staging; Stem cells; Study models; Translating; United States; anticancer research; carcinogenesis; design; genome wide association study; human disease; improved; lectures; meetings; mouse model; outcome forecast; public health relevance; stem; symposium; therapeutic target; tool; tumor

DESCRIPTION (provided by applicant): Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a continuing dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in mice and rats. To this end, the meeting proposed in this application will be hosted by The Jackson Laboratory in Bar Harbor Maine on October 19-22, 2010. Rather than scheduling a series of lectures, we are designing this conference to address six sets of current issues in half-day sessions: 1) Susceptibility/resistance genetic factors and GWAS, 2) Stem and progenitor cells; (poly)clonality; culturing crypts and epithelia, 3) Genomic (in)stability (CIN and MIN) and epigenetic factors (CIMP): The multiple pathway hypothesis; somatic mutations and epimutations; biomarkers for diagnosis and prognosis; serrated, squamous, and rectal tumors; longitudinal studies, 4) Dysplasia; EMT; polarity; (a)symmetric cell division; progression, 5) Inflammation and environmental risk factors; intestinal flora; chemoprevention, and 6) Early detection; therapeutic targets. Each Session will be chaired by an active Rapporteur. We intend to schedule the half-day sessions for morning (9 - 12:30) and afternoon (2:30 - 6:00), each with a 30- minute break. Each session will typically have two 20-minute talks and six 10-minute talks, with five minutes for discussion after each talk. The Rapporteur will provide 10 minutes of introduction at the beginning and lead 10 minutes of general discussion at the end of each half-day session. We believe that the field of research on colon cancer is reaching an exciting point, one that deserves an interactive conference involving both senior and junior investigators. Furthermore, the setting in Bar Harbor will provide a venue in which this sort of conference can thrive, in contrast to larger conferences in urban settings where speakers give lectures and then meet only with pre-determined colleagues. PUBLIC HEALTH RELEVANCE: Colon cancer remains one of the leading health threats in the U.S. today. In order to realize the development of effective models of human cancer, it is critical that basic and clinical researchers maintain clear lines of communication that promote a complete bilateral understanding of the disease and its phenotypes in animal models and how this translates to the study and treatment of the human disease. )

描述（由申请人提供）：结直肠癌是美国癌症死亡的第二大原因。1995年，约有160，000例新的结肠直肠癌病例，60，000人死于这种疾病。在理解病因学和改善这种疾病的治疗方面取得进展的要求之一是开发新的动物模型，其中可以研究正常组织生物学和癌变的所有阶段。这些工具已经到位，可以为癌症研究准备新的小鼠模型;所需要的是基础和临床研究人员之间关于人类肿瘤分子生物学的持续对话，它们的启动和进展与小鼠和大鼠的生物学相关性和建模。为此，本申请中提议的会议将于2010年10月19日至22日由缅因州巴尔港的杰克逊实验室主办。我们没有安排一系列的讲座，而是设计了这次会议，以半天的时间来解决六组当前的问题：1）易感性/抗性遗传因素和GWAS，2）干细胞和祖细胞;（多）克隆性;培养隐窝和上皮细胞，3）基因组稳定性（CIN和MIN）和表观遗传因素（CIMP）：多途径假说;体细胞突变和表观突变;诊断和预后的生物标志物;锯齿状、鳞状和直肠肿瘤;纵向研究，4）发育不良; EMT;极性;（a）对称细胞分裂;进展，5）炎症和环境危险因素;肠道植物群;化学预防，和6）早期检测;治疗靶点。每届会议将由一名现任特别报告员主持。我们打算安排上午（9时至12时30分）和下午（2时30分至6时）举行半天会议，各有30分钟的休息时间。每次会议通常有两个20分钟的会谈和六个10分钟的会谈，每次会谈后有5分钟的讨论。特别报告员将在每次半天会议开始时作10分钟的介绍，并在会议结束时主持10分钟的一般性讨论。我们相信，结肠癌的研究领域正在达到一个令人兴奋的点，值得一个互动的会议，涉及高级和初级研究人员。此外，在巴尔港的设置将提供一个场地，在这种会议可以蓬勃发展，相比之下，在城市环境中，演讲者讲课，然后只与预先确定的同事见面的大型会议。 公共卫生相关性：结肠癌仍然是当今美国主要的健康威胁之一。为了实现有效的人类癌症模型的发展，基础和临床研究人员保持清晰的沟通渠道至关重要，这将促进对疾病及其动物模型表型的全面了解，以及如何将其转化为人类疾病的研究和治疗。)