Functional MRI of anti-tobacco public service announcements

反烟草公共服务公告的功能性 MRI

• 批准号: 8073249
• 负责人: DANIEL D LANGLEBEN
• 金额: $ 24万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073249
• 关键词: AIDS prevention; AIDS/HIV problem; Adult; African American; Anti-Retroviral Agents; Antismoking; Area; Attitude; Behavior; Behavioral; Belief; Brain; Brain imaging; Data; Development; Education; Esthesia; Ethnic Origin; Evaluation; Functional Magnetic Resonance Imaging; Goals; HIV; HIV Infections; Health Communication; Immediate Recalls; Learning; Mass Media; Measures; Media Campaign; Methodology; Methods; Morbidity - disease rate; Neurobiology; Neurosciences; Outcome; Outcome Measure; Parents; Pharmaceutical Preparations; Primary Prevention; Public Health; Reporting; Safe Sex; Self Efficacy; Services; Signal Transduction; Tobacco; Translating; Work; age group; base; condoms; cost; design; global health; improved; mortality; neurophysiology; parent grant; public health relevance; response; sex; social; social implication; tool; translational study

DESCRIPTION (provided by applicant): HIV/AIDS is a critical global health problem. Despite growing efficacy of anti- retroviral medications, primary prevention is still the most effective way to alleviate mortality, morbidity and suffering caused by HIV/AIDS. Mass media campaigns using televised public service announcements (PSAs) are a key tool of HIV prevention. The critical importance of primary prevention in HIV/AIDS makes efforts to quantify the mechanisms of PSA impact highly cost-effective. Any incremental increase in the efficacy of HIV-PSAs is amplified by the broad reach of mass media. Functional Magnetic Resonance Imaging (fMRI) is an established neuroscience tool that has been effectively applied to the evaluation of the brain effects of mass audiovisual media. Recent reports indicate that fMRI may be used to predict the neurobiology of action of anti-smoking PSAs. Specifically, Message Sensation Value (MSV) has been identified as a PSA variable that has both behavioral and fMRI correlates. The goal of the parent grant was to investigate the brain correlates of the anti-smoking PSAs MSV and argument strength. Using brain imaging methodology previously established with anti-tobacco PSAs (and other screen media), the present competitive revision proposal will investigate the interaction of MSV with behavioral (short term recall, safe sex and condom use attitudes) and neurophysiological (brain fMRI signal) measures to inform the evaluation and design of HIV PSAs. Results of this exploratory translational study could be instrumental in laying the groundwork towards optimization of the design and evaluation of mass media public health communications in the area of HIV/AIDS. The ultimate goal of the present competitive supplement proposal is to improve the efficacy of the televised HIV prevention campaigns. By demonstrating that the parent proposal findings generalize to HIV PSA, this competitive revision will give the parent grant broad social relevance, as high sensation value messages are currently widely used in general education. PUBLIC HEALTH RELEVANCE: The present competitive revision is to extend and translate the findings of the parent grant and the pilot data that preceded it, to HIV prevention public service announcements (PSAs). Results of this study would be instrumental in extending the findings of the parent grant to HIV PSAs, and demonstrating the potential of using brain imaging to optimize the design and evaluation of HIV PSAs. The ultimate goal of this proposal is to improve the efficacy of the televised HIV- prevention campaigns. The use of high sensation value messages in general education (i.e."edutainment") makes this proposal broadly socially relevant.

描述(申请人提供)：艾滋病毒/艾滋病是一个严重的全球健康问题。尽管抗逆转录病毒药物的疗效越来越高，但初级预防仍然是减少艾滋病毒/艾滋病造成的死亡率、发病率和痛苦的最有效途径。使用电视公共服务公告(PSA)的大众媒体宣传活动是预防艾滋病毒的关键工具。艾滋病毒/艾滋病初级预防的极端重要性使量化PSA影响机制的努力具有极高的成本效益。大众媒体的广泛影响放大了艾滋病毒-PSA效力的任何递增。功能磁共振成像(FMRI)是一种成熟的神经科学工具，已被有效地应用于评估大众视听媒体的大脑效应。最近的报道表明，功能磁共振成像可以用来预测禁烟PSA的神经生物学作用。具体地说，消息感觉值(MSV)已被确定为同时具有行为和功能磁共振相关的PSA变量。家长资助的目标是调查反吸烟的PSA、MSV和论点强度之间的大脑相关性。使用以前与反烟草PSA(和其他屏幕媒体)建立的脑成像方法，本竞争性修订提案将调查MSV与行为(短期回忆、安全性行为和避孕套使用态度)和神经生理(脑功能磁共振信号)指标的交互作用，以为HIV PSA的评估和设计提供信息。这一探索性转化研究的结果可能有助于为优化艾滋病毒/艾滋病领域大众媒体公共卫生传播的设计和评价奠定基础。目前竞争性补充方案的最终目标是提高电视转播的艾滋病毒预防运动的效果。通过证明家长提案的调查结果概括到艾滋病毒PSA，这一竞争性修订将赋予家长赠款广泛的社会相关性，因为高感觉价值的信息目前在普通教育中被广泛使用。 公共卫生相关性：目前的竞争性修订是将父母赠款的结果和之前的试点数据扩展和翻译为艾滋病毒预防公共服务公告(PSA)。这项研究的结果将有助于扩大父母对艾滋病毒公益广告的资助结果，并展示利用脑成像来优化艾滋病毒公益广告的设计和评估的潜力。这项提议的最终目标是提高电视转播的艾滋病毒预防运动的效果。在普通教育中使用高感官价值的信息(即“教育娱乐”)使这一建议具有广泛的社会意义。

项目成果

Using Brain Imaging for Lie Detection: Where Science, Law and Research Policy Collide.

• DOI: 10.1037/a0028841
• 发表时间: 2013-05-01
• 期刊: PSYCHOLOGY PUBLIC POLICY AND LAW
• 影响因子: 2
• 作者: Langleben, Daniel D.;Moriarty, Jane Campbell
• 通讯作者: Moriarty, Jane Campbell

Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements.

• DOI: 10.1523/jneurosci.3840-12.2013
• 发表时间: 2013-04-24
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Wang AL;Ruparel K;Loughead JW;Strasser AA;Blady SJ;Lynch KG;Romer D;Cappella JN;Lerman C;Langleben DD
• 通讯作者: Langleben DD