Infrastructure and Opportunity Fund Management
基础设施和机会基金管理
基本信息
- 批准号:8328003
- 负责人:
- 金额:$ 83.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-08-01 至 2016-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAllergensAllergic DiseaseAllergic inflammationAmplifiersApplication procedureAreaAsthmaAwardBudgetsChronicClinicalClinical ResearchCollaborationsCommunity Acquired Respiratory Distress Syndrome ToxinDevelopmentDiagnosticDiseaseDisease ProgressionEligibility DeterminationFunctional disorderFundingFunding OpportunitiesGoalsIndividualInfectionInflammationInflammatoryInjuryInnovative TherapyInstructionInvestigationLeadLinkLymphocyteMediator of activation proteinModelingMolecularMucous body substanceMusMycoplasma pneumoniaeNational Institute of Allergy and Infectious DiseaseOvalbuminPathologyPathway interactionsPatientsPneumoniaProteinsPulmonary PathologyPyroglyphidaeQualifyingReagentRecombinantsRecruitment ActivityRelative (related person)ResearchResearch InfrastructureResearch PersonnelResource DevelopmentRoleStructureTissuesToxinViralimprovedinnovationinsightmemberoutcome forecastpollutantpreventprospectivetool
项目摘要
The purpose of the Infrastructure and Opportunity Fund IVIanagement (lOFM) Core is to create
and facilitate collaborations between NIAID-sponsored AADCRCs through new clinical researcii
and resource development projects; support promising opportunities that advance an understanding
of the pathophysiology of asthma and allergic diseases; and develop improved therapies to reduce
or prevent disease progression. Since the focus of the SA-AADCRC emphasizes the Induction and
exacerbation of Inflammatory pathways and tissue Injury, as viewed from the perspective of
Mycoplasma pneumoniae and its unique ADP ribosylating and vacuolating toxin, designated
Community Acquired Respiratory Distress Syndrome Toxin (CARDS TX), many collaborative and
synergetic opportunities exist among AADCRC members. The ability of CARDS TX alone to both
Induce asthma-like disease and exacerbate allergic Inflammation places this remarkable pathogenic
factor as a potential sole mediator, or amplifier, or co-factor in a broad range of ainA/ay conditions
that lead to acute and chronic pulmonary pathologies. Therefore, the relationships between M.
pneumoniae and other environmental triggers could be very Impactful and revealing, as M.
pneumoniae infections are common and persistent and CARDS TX produces lymphocytic
Inflammation, mucous hypersecretion, and hyperreactivity. Importantly, CARDS TX protein can be
readily detected in airway secretions of asthmatic subjects and by Itself exacerbates
eosinophilic/lymphocytic Inflammation and hyperresponsiveness to ovalbumin and house dust mite
In the murine model. Collaborations with AADCRCs that examine viral and other Infectious
pollutants and allergens could lead to understanding how certain individuals manifest exaggerated
Inflammatory responsiveness as a result of M. pneumoniae and CARDS TX presence/persistence.
Also, recombinant CARDS TX and other related reagents could serve as useful tools to share
among AADCRCs for studying the molecular and pathophysiological mechanisms that precipitate
asthma-like pulmonary Inflammation and associated pathologies.
基础设施和机会基金IVIanimals(IOFM)核心的目的是创建
并通过新的临床研究促进NIAID申办的AADCRC之间的合作
资源开发项目;支持有希望的机会,
哮喘和过敏性疾病的病理生理学;并开发改进的治疗方法,
或阻止疾病进展。由于SA-AADCRC的重点强调了入门和
炎症途径和组织损伤的恶化,从以下角度来看:
肺炎支原体及其独特的ADP核糖基化和空泡化毒素,
社区获得性呼吸窘迫综合征毒素(CRTX),许多合作和
AADCRC成员之间存在协同增效的机会。单凭一个人的力量,
诱发哮喘样疾病和加剧过敏性炎症的地方,这一显着的致病性
因子作为潜在的唯一介质,或放大器,或在广泛的条件下的辅助因子
导致急性和慢性肺部病变。因此,M.
肺炎和其他环境触发因素可能是非常有影响力和揭示,因为M。
肺炎感染是常见的和持久的,
炎症、粘液分泌过多和高反应性。重要的是,BTX蛋白可以是
容易在哮喘患者的气道分泌物中检测到,
嗜酸性/淋巴细胞性炎症和对卵清蛋白和屋尘螨的高反应性
在小鼠模型中。与AADCRC合作,检查病毒和其他传染性疾病
污染物和过敏原可能导致理解某些人如何表现出夸大的
炎症反应是M.肺炎和肺炎支原体存在/持续存在。
此外,重组MTX和其他相关试剂可以作为有用的工具分享
在AADCRCs中研究沉淀的分子和病理生理机制,
哮喘样肺部炎症和相关病理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOEL Barry BASEMAN其他文献
JOEL Barry BASEMAN的其他文献
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{{ truncateString('JOEL Barry BASEMAN', 18)}}的其他基金
Role of host cell invasion in Mycoplasma genitalium persistent infection
宿主细胞侵袭在生殖支原体持续感染中的作用
- 批准号:
9197256 - 财政年份:2015
- 资助金额:
$ 83.49万 - 项目类别:
Biochemical, molecular and immunological characterization of Mycoplasma pneumoni
肺炎支原体的生化、分子和免疫学特征
- 批准号:
8328001 - 财政年份:2011
- 资助金额:
$ 83.49万 - 项目类别:
Role of unique ADP-ribosylating vacuolating Mycoplasma pneumoniae toxin in asthma
独特的 ADP-核糖基化空泡肺炎支原体毒素在哮喘中的作用
- 批准号:
7914874 - 财政年份:2009
- 资助金额:
$ 83.49万 - 项目类别:
Biochemical, Molecular &Immunological Characterization of the Mycoplasma pneumon
生化、分子
- 批准号:
7686482 - 财政年份:2008
- 资助金额:
$ 83.49万 - 项目类别:
Role of unique ADP-ribosylating vacuolating Mycoplasma pneumoniae toxin in asthma
独特的 ADP-核糖基化空泡肺炎支原体毒素在哮喘中的作用
- 批准号:
7274288 - 财政年份:2006
- 资助金额:
$ 83.49万 - 项目类别:
Role of unique ADP-ribosylating vacuolating Mycoplasma pneumoniae toxin i
独特的 ADP-核糖基化空泡肺炎支原体毒素 i 的作用
- 批准号:
8300811 - 财政年份:2006
- 资助金额:
$ 83.49万 - 项目类别:
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