Maternal Fetal Medicine Units Network

母胎医学单位网络

基本信息

批准号：
8081491
负责人：
GEORGE R. SAADE
金额：
$ 30.6万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-15 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8081491
关键词：
Acute Address Adherence Admission activity Ambulatory Care Facilities Antioxidants Area Award Basic Science Beds Birth Caring Cephalic Cervix Uteri Clinic Clinical Clinical Pathology Clinical Research Clinical Services Clinical Trials Collaborations Commit Communities Competitive Bidding Computerized Medical Record Consent Core Facility County Critical Care Data Data Analyses Data Collection Data Quality Development Diagnostic Discipline of obstetrics Documentation Employee Enrollment Equipoise Evaluation Evidence based practice Faculty Funding Genetic Genomics Gestational Diabetes Goals Health High-Risk Pregnancy Home environment Hospitals Human Resources Individual Indomethacin Information Systems Informed Consent Inpatients Institutes Institution Investigation Laboratories Lead Leadership Letters Life Link Logistics Low Birth Weight Infant Magnesium Sulfate Maternal and Child Health Medical Mission Mosses Multicenter Trials National Institute of Child Health and Human Development Neonatal Neonatal Intensive Care Units Neonatology Network-based Neurologic Neurologist Nifedipine Notification Nursing Research Occupational Therapist Ophthalmologist Outcome Outpatients Pathology Patient Care Patient Recruitments Patient Rights Patients Pediatrics Perinatal Persons Pharmacology Pharmacy facility Physician Executives Policies Population Population Study Positioning Attribute Pre-Eclampsia Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Premature Labor Prenatal Diagnosis Prenatal care Prevention Principal Investigator Procedures Productivity Proteomics Protocols documentation Public Health Publications Radiology Specialty Randomized Randomized Clinical Trials Recruitment Activity Research Research Design Research Infrastructure Research Personnel Screening procedure Services Site Spontaneous abortion System Texas Time Tissues Tocolysis Translational Research U-Series Cooperative Agreements Ultrasonography United States National Institutes of Health Universities Visit Woman biobank clinical infrastructure clinical practice design experience fetal fetal medicine follow-up high risk improved innovation intrapartum medical schools member premature prenatal prevent programs protocol violation randomized trial sample collection stillbirth treatment trial

项目摘要

DESCRIPTION (provided by applicant): During our first cycle in the MFMU Network, we demonstrated the ability of our clinical and research infrastructure at The University of Texas Medical Branch (UTMB) to effectively contribute to multisite trials. In addition to productivity in the MFMU Network, the PI, George Saade, and alternate PI, Gary Hankins, bring extensive experience in study design, recruitment, data analysis, and publications from several non-MFMU Networks, such as the Stillbirth Collaborative Research Network, Obstetric Pharmacology Research Units Network, and Genomic/Proteomic Network for Premature Birth Research. We achieved successful patient recruitment and retention through our Department's Regional Maternal & Child Health Program (RMCHP). RMCHP clinics, following protocols set by the Maternal-Fetal Medicine Division, provided prenatal care for more than 12,000 multiethnic pregnant women in 2009. We deliver over 5,000 high-risk pregnancies a year, with more than 90% receiving prenatal care in our system. The Department's Electronic Medical Record System (EMR) captures antepartum and intrapartum data online and is readily available to authorized research personnel for query as well as automatic notification. The EMR and policies/procedures have been successfully adapted to maximize our research productivity. The MFM Division, Tissue BioBank, and team of dedicated research staff in the Perinatal Research Division (PRD), all under the direction of the PI, have broadened efficiency in clinical investigations. Joan Moss, MFMU Research Nurse Coordinator, brings extensive experience and expertise to the team. The prolific collaboration between PI and alternate PI, who is also Department Chair and RMCHP Medical Director, offers further benefit and efficacy to the Network. As the chief of OB, the PI directs the medical management of all Obstetrical patients at UTMB. Our Department has a well-funded basic science research group with expertise in many areas of relevance to the RFA. Finally, we have well-established collaborative ties with our University's Divisions of Neonatology, Genetics, Perinatal Pathology, Clinical Laboratory, and Radiology. At all levels, UTMB emphasizes research in general, with multiple core facilities available to the Network, including the Institute of Translational Research, the home for UTMB's CTSA. Our Department is consistently one of the top NIH- funded Ob/Gyn departments in the nation. In our concept protocol, we propose to compare the neonatal outcomes following acute tocolysis with nifedipine vs. indomethacin. We accept the RFA's capitation and participatory stipulations and stand ready to continue as productive members of the Network. PUBLIC HEALTH RELEVANCE: Investigations by the MFMU Network focus on problems in clinical obstetrics, particularly those related to prevention of low birth weight, prematurity, and medical problems of pregnancy. These complications can lead to health problems at birth as well as later in life; therefore, research that may lead to their prevention has powerful potential for improving individual lives and public health.

描述（由申请人提供）：在我们在MFMU网络中的第一个周期中，我们证明了德克萨斯大学医学分公司（UTMB）有效促进多站点试验的临床和研究基础设施的能力。除了在MFMU网络中的生产力外，PI，George Saade和备用PI，Gary Hankins，还带来了来自多个非MFMU网络的研究设计，招聘，数据分析和出版物方面的丰富经验，例如StillBirth Collaborative Collaborative Collaborative Consemborative Consergion网络，OriveTric Pharmactric研究单位网络和基因组蛋白质综合网络，以供代表生育研究。我们通过部门的区域产妇和儿童健康计划（RMCHP）成功地招募了患者和保留。根据母亲医学部设定的方案，RMCHP诊所在2009年为超过12,000名多民族孕妇提供了产前护理。我们每年提供5,000多次高危妊娠，超过90％的人在我们的系统中获得产前护理。该部门的电子病历系统（EMR）在线捕获了天哪和产前数据，并且很容易为授权的研究人员提供查询以及自动通知。 EMR和政策/程序已成功地适应我们的研究生产率。 MFM部门，组织生物库和围产期研究部门专门研究人员的团队在PI的指导下都扩大了临床研究的效率。 MFMU研究护士协调员Joan Moss为团队带来了丰富的经验和专业知识。 PI和替代Pi之间的多产合作（也是部门主席兼RMCHP医疗总监）为网络提供了进一步的好处和功效。作为OB的负责人，PI指导UTMB所有产科患者的医疗管理。我们的部门在与RFA相关的许多领域中拥有一个资金丰富的基础科学研究小组。最后，我们与大学的新生儿学，遗传学，围产期病理学，临床实验室和放射学的分歧建立了良好的合作关系。 UTMB在各个层面上都强调了研究，网络可提供多个核心设施，包括转化研究所，UTMB CTSA的所在地。我们的部门一直是美国国立卫生研究院最高的OB/GYN部门之一。在我们的概念方案中，我们建议将急性淋巴结后的新生儿结果与硝苯地平与吲哚美辛进行比较。我们接受RFA的角色和参与式规定，并准备继续作为网络的生产成员。公共卫生相关性：MFMU网络的调查重点关注临床妇产科问题，尤其是与预防低出生体重，早产和妊娠问题有关的问题。这些并发症可能导致出生时以及生命后期的健康问题。因此，可能导致他们预防的研究具有改善个人生活和公共卫生的强大潜力。