Maternal Fetal Medicine Units Network

母胎医学单位网络

• 批准号: 8081491
• 负责人: GEORGE R. SAADE
• 金额: $ 30.6万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8081491
• 关键词: Acute; Address; Adherence; Admission activity; Ambulatory Care Facilities; Antioxidants; Area; Award; Basic Science; Beds; Birth; Caring; Cephalic; Cervix Uteri; Clinic; Clinical; Clinical Pathology; Clinical Research; Clinical Services; Clinical Trials; Collaborations; Commit; Communities; Competitive Bidding; Computerized Medical Record; Consent; Core Facility; County; Critical Care; Data; Data Analyses; Data Collection; Data Quality; Development; Diagnostic; Discipline of obstetrics; Documentation; Employee; Enrollment; Equipoise; Evaluation; Evidence based practice; Faculty; Funding; Genetic; Genomics; Gestational Diabetes; Goals; Health; High-Risk Pregnancy; Home environment; Hospitals; Human Resources; Individual; Indomethacin; Information Systems; Informed Consent; Inpatients; Institutes; Institution; Investigation; Laboratories; Lead; Leadership; Letters; Life; Link; Logistics; Low Birth Weight Infant; Magnesium Sulfate; Maternal and Child Health; Medical; Mission; Mosses; Multicenter Trials; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Neonatology; Network-based; Neurologic; Neurologist; Nifedipine; Notification; Nursing Research; Occupational Therapist; Ophthalmologist; Outcome; Outpatients; Pathology; Patient Care; Patient Recruitments; Patient Rights; Patients; Pediatrics; Perinatal; Persons; Pharmacology; Pharmacy facility; Physician Executives; Policies; Population; Population Study; Positioning Attribute; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Premature Labor; Prenatal Diagnosis; Prenatal care; Prevention; Principal Investigator; Procedures; Productivity; Proteomics; Protocols documentation; Public Health; Publications; Radiology Specialty; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Screening procedure; Services; Site; Spontaneous abortion; System; Texas; Time; Tissues; Tocolysis; Translational Research; U-Series Cooperative Agreements; Ultrasonography; United States National Institutes of Health; Universities; Visit; Woman; biobank; clinical infrastructure; clinical practice; design; experience; fetal; fetal medicine; follow-up; high risk; improved; innovation; intrapartum; medical schools; member; premature; prenatal; prevent; programs; protocol violation; randomized trial; sample collection; stillbirth; treatment trial

DESCRIPTION (provided by applicant): During our first cycle in the MFMU Network, we demonstrated the ability of our clinical and research infrastructure at The University of Texas Medical Branch (UTMB) to effectively contribute to multisite trials. In addition to productivity in the MFMU Network, the PI, George Saade, and alternate PI, Gary Hankins, bring extensive experience in study design, recruitment, data analysis, and publications from several non-MFMU Networks, such as the Stillbirth Collaborative Research Network, Obstetric Pharmacology Research Units Network, and Genomic/Proteomic Network for Premature Birth Research. We achieved successful patient recruitment and retention through our Department's Regional Maternal & Child Health Program (RMCHP). RMCHP clinics, following protocols set by the Maternal-Fetal Medicine Division, provided prenatal care for more than 12,000 multiethnic pregnant women in 2009. We deliver over 5,000 high-risk pregnancies a year, with more than 90% receiving prenatal care in our system. The Department's Electronic Medical Record System (EMR) captures antepartum and intrapartum data online and is readily available to authorized research personnel for query as well as automatic notification. The EMR and policies/procedures have been successfully adapted to maximize our research productivity. The MFM Division, Tissue BioBank, and team of dedicated research staff in the Perinatal Research Division (PRD), all under the direction of the PI, have broadened efficiency in clinical investigations. Joan Moss, MFMU Research Nurse Coordinator, brings extensive experience and expertise to the team. The prolific collaboration between PI and alternate PI, who is also Department Chair and RMCHP Medical Director, offers further benefit and efficacy to the Network. As the chief of OB, the PI directs the medical management of all Obstetrical patients at UTMB. Our Department has a well-funded basic science research group with expertise in many areas of relevance to the RFA. Finally, we have well-established collaborative ties with our University's Divisions of Neonatology, Genetics, Perinatal Pathology, Clinical Laboratory, and Radiology. At all levels, UTMB emphasizes research in general, with multiple core facilities available to the Network, including the Institute of Translational Research, the home for UTMB's CTSA. Our Department is consistently one of the top NIH- funded Ob/Gyn departments in the nation. In our concept protocol, we propose to compare the neonatal outcomes following acute tocolysis with nifedipine vs. indomethacin. We accept the RFA's capitation and participatory stipulations and stand ready to continue as productive members of the Network. PUBLIC HEALTH RELEVANCE: Investigations by the MFMU Network focus on problems in clinical obstetrics, particularly those related to prevention of low birth weight, prematurity, and medical problems of pregnancy. These complications can lead to health problems at birth as well as later in life; therefore, research that may lead to their prevention has powerful potential for improving individual lives and public health.

描述(由申请人提供)：在我们在MFMU网络的第一个周期中，我们展示了我们在德克萨斯大学医学部(UTMB)的临床和研究基础设施有效促进多站点试验的能力。除了MFMU网络的生产力外，PIGeorge Saade和候补PIGary Hankins还在研究设计、招募、数据分析和来自几个非MFMU网络的出版物方面拥有丰富的经验，这些网络包括静产合作研究网络、产科药理学研究单位网络和早产研究基因组/蛋白质组网络。我们通过我们部门的区域妇幼保健计划(RMCHP)成功地招募和留住了患者。2009年，RMCHP诊所按照母胎医学司制定的方案，为12000多名多民族孕妇提供了产前护理。我们每年接生5000多例高危妊娠，其中90%以上在我们的系统中接受产前护理。该司的电子医疗记录系统(EMR)可在线获取产前和产中数据，并可供授权研究人员查询和自动通知。电子病历和政策/程序已成功调整，以最大限度地提高我们的研究效率。MFM分部、组织生物库和围产期研究部(PRD)的专职研究人员团队都在PI的指导下，扩大了临床研究的效率。MFMU研究护士协调员Joan Moss为团队带来了丰富的经验和专业知识。PI和候补PI之间的大量合作为该网络提供了更多的好处和功效。作为产科主任，PI指导UTMB所有产科病人的医疗管理。我们部有一个资金充足的基础科学研究小组，在许多与RFA相关的领域拥有专门知识。最后，我们与我们大学的新生儿科、遗传学、围产期病理学、临床实验室和放射科建立了良好的合作关系。在各级，UTMB强调总体研究，网络拥有多个核心设施，包括UTMB CTSA的总部所在地--翻译研究所。我们的部门一直是美国国立卫生研究院资助的妇产科的顶级部门之一。在我们的概念性方案中，我们建议比较硝苯地平和吲哚美辛治疗急性宫内翻转的新生儿结局。我们接受RFA的强制要求和参与性规定，并随时准备继续作为该网络的富有成效的成员。 公共卫生相关性：MFMU网络的调查重点是临床产科的问题，特别是与预防低出生体重、早产和怀孕的医学问题有关的问题。这些并发症可能导致出生时和以后的健康问题；因此，可能导致预防这些并发症的研究在改善个人生活和公共卫生方面具有强大的潜力。