Maternal Fetal Medicine Units Network

描述（由申请人提供）：在我们在MFMU网络的第一个周期中，我们展示了我们在德克萨斯大学医学分部（UTMB）的临床和研究基础设施有效促进多地点试验的能力。除了MFMU网络的生产力外，PI George Saade和替代PI Gary Hankins在研究设计，招募，数据分析和来自几个非MFMU网络（如死产合作研究网络，产科药理学研究单位网络和早产研究基因组/蛋白质组学网络）的出版物方面带来了丰富的经验。我们通过本部门的区域妇幼保健计划（RMCHP）成功地招募和保留了患者。2009年，根据母胎医学部制定的规程，RMCHP诊所为1.2万多民族孕妇提供了产前护理。我们每年为5000多名高危孕妇接生，其中90%以上在我们的系统中接受产前护理。该部门的电子医疗记录系统（EMR）在线捕获产前和分娩时的数据，并随时可供授权的研究人员查询和自动通知。电子病历和政策/程序已成功调整，以最大限度地提高我们的研究效率。MFM部门、组织生物库和围产期研究部门（PRD）的专业研究人员团队，都在PI的指导下，扩大了临床调查的效率。Joan Moss， MFMU研究护士协调员，为团队带来了丰富的经验和专业知识。PI和副PI之间的丰富合作，同时也是部门主席和RMCHP医学主任，为网络提供了进一步的好处和功效。作为产科主任，产科主任指导UTMB所有产科患者的医疗管理。我们系有一个资金充足的基础科学研究小组，在许多与RFA相关的领域拥有专业知识。最后，我们与我校的新生儿科、遗传学、围产期病理学、临床实验室和放射科建立了良好的合作关系。在所有层面上，UTMB强调一般的研究，有多个核心设施可供网络使用，包括转化研究所，UTMB CTSA的所在地。我们的部门一直是美国国家卫生研究院资助的顶级妇产科部门之一。在我们的概念方案中，我们建议比较硝苯地平和吲哚美辛急性胎溶后的新生儿结局。我们接受区域自由贸易区的出资和参与规定，并随时准备继续作为该网络的富有成效的成员。

DESCRIPTION (provided by applicant): During our first cycle in the MFMU Network, we demonstrated the ability of our clinical and research infrastructure at The University of Texas Medical Branch (UTMB) to effectively contribute to multisite trials. In addition to productivity in the MFMU Network, the PI, George Saade, and alternate PI, Gary Hankins, bring extensive experience in study design, recruitment, data analysis, and publications from several non-MFMU Networks, such as the Stillbirth Collaborative Research Network, Obstetric Pharmacology Research Units Network, and Genomic/Proteomic Network for Premature Birth Research. We achieved successful patient recruitment and retention through our Department's Regional Maternal & Child Health Program (RMCHP). RMCHP clinics, following protocols set by the Maternal-Fetal Medicine Division, provided prenatal care for more than 12,000 multiethnic pregnant women in 2009. We deliver over 5,000 high-risk pregnancies a year, with more than 90% receiving prenatal care in our system. The Department's Electronic Medical Record System (EMR) captures antepartum and intrapartum data online and is readily available to authorized research personnel for query as well as automatic notification. The EMR and policies/procedures have been successfully adapted to maximize our research productivity. The MFM Division, Tissue BioBank, and team of dedicated research staff in the Perinatal Research Division (PRD), all under the direction of the PI, have broadened efficiency in clinical investigations. Joan Moss, MFMU Research Nurse Coordinator, brings extensive experience and expertise to the team. The prolific collaboration between PI and alternate PI, who is also Department Chair and RMCHP Medical Director, offers further benefit and efficacy to the Network. As the chief of OB, the PI directs the medical management of all Obstetrical patients at UTMB. Our Department has a well-funded basic science research group with expertise in many areas of relevance to the RFA. Finally, we have well-established collaborative ties with our University's Divisions of Neonatology, Genetics, Perinatal Pathology, Clinical Laboratory, and Radiology. At all levels, UTMB emphasizes research in general, with multiple core facilities available to the Network, including the Institute of Translational Research, the home for UTMB's CTSA. Our Department is consistently one of the top NIH- funded Ob/Gyn departments in the nation. In our concept protocol, we propose to compare the neonatal outcomes following acute tocolysis with nifedipine vs. indomethacin. We accept the RFA's capitation and participatory stipulations and stand ready to continue as productive members of the Network.