Maternal Fetal Medicine Units Network

母胎医学单位网络

• 批准号: 8251932
• 负责人: GEORGE R. SAADE
• 金额: $ 30.14万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251932
• 关键词: Acute; Address; Adherence; Admission activity; Ambulatory Care Facilities; Antioxidants; Area; Award; Basic Science; Beds; Birth; Caring; Cephalic; Cervix Uteri; Clinic; Clinical; Clinical Pathology; Clinical Research; Clinical Services; Clinical Trials; Collaborations; Commit; Communities; Competitive Bidding; Computerized Medical Record; Consent; Core Facility; County; Critical Care; Data; Data Analyses; Data Collection; Data Quality; Development; Diagnostic; Discipline of obstetrics; Documentation; Employee; Enrollment; Equipoise; Evaluation; Evidence based practice; Faculty; Funding; Genetic; Genomics; Gestational Diabetes; Goals; Health; High-Risk Pregnancy; Home environment; Hospitals; Human Resources; Individual; Indomethacin; Information Systems; Informed Consent; Inpatients; Institutes; Institution; Investigation; Laboratories; Lead; Leadership; Letters; Life; Link; Logistics; Low Birth Weight Infant; Magnesium Sulfate; Maternal and Child Health; Medical; Mission; Mosses; Multicenter Trials; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Neonatology; Network-based; Neurologic; Neurologist; Nifedipine; Notification; Nursing Research; Occupational Therapist; Ophthalmologist; Outcome; Outpatients; Pathology; Patient Care; Patient Recruitments; Patient Rights; Patients; Pediatrics; Perinatal; Persons; Pharmacology; Pharmacy facility; Physician Executives; Policies; Population; Population Study; Positioning Attribute; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Premature Labor; Prenatal Diagnosis; Prenatal care; Prevention; Principal Investigator; Procedures; Productivity; Proteomics; Protocols documentation; Public Health; Publications; Radiology Specialty; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Screening procedure; Services; Site; Spontaneous abortion; System; Texas; Time; Tissues; Tocolysis; Translational Research; U-Series Cooperative Agreements; Ultrasonography; United States National Institutes of Health; Universities; Visit; Woman; biobank; clinical infrastructure; clinical practice; design; experience; fetal; fetal medicine; follow-up; high risk; improved; innovation; intrapartum; medical schools; member; premature; prenatal; prevent; programs; protocol violation; public health relevance; randomized trial; sample collection; stillbirth; treatment trial

DESCRIPTION (provided by applicant): During our first cycle in the MFMU Network, we demonstrated the ability of our clinical and research infrastructure at The University of Texas Medical Branch (UTMB) to effectively contribute to multisite trials. In addition to productivity in the MFMU Network, the PI, George Saade, and alternate PI, Gary Hankins, bring extensive experience in study design, recruitment, data analysis, and publications from several non-MFMU Networks, such as the Stillbirth Collaborative Research Network, Obstetric Pharmacology Research Units Network, and Genomic/Proteomic Network for Premature Birth Research. We achieved successful patient recruitment and retention through our Department's Regional Maternal & Child Health Program (RMCHP). RMCHP clinics, following protocols set by the Maternal-Fetal Medicine Division, provided prenatal care for more than 12,000 multiethnic pregnant women in 2009. We deliver over 5,000 high-risk pregnancies a year, with more than 90% receiving prenatal care in our system. The Department's Electronic Medical Record System (EMR) captures antepartum and intrapartum data online and is readily available to authorized research personnel for query as well as automatic notification. The EMR and policies/procedures have been successfully adapted to maximize our research productivity. The MFM Division, Tissue BioBank, and team of dedicated research staff in the Perinatal Research Division (PRD), all under the direction of the PI, have broadened efficiency in clinical investigations. Joan Moss, MFMU Research Nurse Coordinator, brings extensive experience and expertise to the team. The prolific collaboration between PI and alternate PI, who is also Department Chair and RMCHP Medical Director, offers further benefit and efficacy to the Network. As the chief of OB, the PI directs the medical management of all Obstetrical patients at UTMB. Our Department has a well-funded basic science research group with expertise in many areas of relevance to the RFA. Finally, we have well-established collaborative ties with our University's Divisions of Neonatology, Genetics, Perinatal Pathology, Clinical Laboratory, and Radiology. At all levels, UTMB emphasizes research in general, with multiple core facilities available to the Network, including the Institute of Translational Research, the home for UTMB's CTSA. Our Department is consistently one of the top NIH- funded Ob/Gyn departments in the nation. In our concept protocol, we propose to compare the neonatal outcomes following acute tocolysis with nifedipine vs. indomethacin. We accept the RFA's capitation and participatory stipulations and stand ready to continue as productive members of the Network. PUBLIC HEALTH RELEVANCE: Investigations by the MFMU Network focus on problems in clinical obstetrics, particularly those related to prevention of low birth weight, prematurity, and medical problems of pregnancy. These complications can lead to health problems at birth as well as later in life; therefore, research that may lead to their prevention has powerful potential for improving individual lives and public health.

描述（由申请人提供）：在MFMU网络的第一个周期中，我们证明了德克萨斯大学医学分支（UTMB）的临床和研究基础设施有效促进多中心试验的能力。除了MFMU网络的生产力外，PI乔治Saade和候补PI加里汉金斯在研究设计、招募、数据分析和几个非MFMU网络（如死产协作研究网络、产科药理学研究单位网络和早产研究基因组/蛋白质组学网络）的出版物方面拥有丰富的经验。我们通过我们部门的区域妇幼保健计划（RMCHP）成功地招募和留住了病人。2009年，RMCHP诊所按照母胎医学司制定的协议，为12 000多名多族裔孕妇提供了产前护理。我们每年为5,000多名高危孕妇提供服务，其中90%以上的孕妇在我们的系统中接受产前护理。该部门的电子医疗记录系统（EMR）在线采集产前和分娩期间的数据，并随时提供给授权的研究人员进行查询以及自动通知。EMR和政策/程序已经成功地调整，以最大限度地提高我们的研究生产力。MFM部门、组织生物库和围产期研究部门（PRD）的专职研究人员团队都在PI的指导下，扩大了临床研究的效率。琼莫斯，MFMU研究护士协调员，带来了丰富的经验和专业知识的团队。PI和候补PI（也是部门主席和RMCHP医学主任）之间的多产合作为网络提供了进一步的好处和功效。作为产科主任，PI指导UTMB所有产科患者的医疗管理。我们部门有一个资金充足的基础科学研究小组，在许多与RFA相关的领域拥有专业知识。最后，我们与我们大学的新生儿科，遗传学，围产期病理学，临床实验室和放射学部门建立了良好的合作关系。在各个层面上，UTMB强调一般的研究，有多个核心设施提供给网络，包括转化研究所，UTMB的CTSA的家。我们的部门一直是美国国立卫生研究院资助的妇产科在全国最好的部门之一。在我们的概念方案中，我们建议比较硝苯地平与吲哚美辛急性安胎后的新生儿结局。我们接受外地住房安排的人头和参与规定，并随时准备继续作为该网络的富有成效的成员。 公共卫生关系：MFMU网络的调查重点是临床产科问题，特别是与预防低出生体重、早产和怀孕医疗问题有关的问题。这些并发症可能导致出生时以及以后的生活中的健康问题;因此，可能导致其预防的研究具有改善个人生活和公共卫生的强大潜力。