Scope and Causes of Stillbirth

描述(由申请人提供)：德克萨斯大学加尔维斯顿分校(UTMB)有能力作为NIH多站点静产网络的成员积极参与。Pi George R.Saade医学博士在多个NIH多点临床试验中提供了丰富的经验，这些试验包括：非整倍体风险的早期和中期评估(FAST)；妊娠早期颈部半透明与先天性心脏病的风险；双胞胎输血综合征试验；以及产前硫酸镁研究(BEAM)的有益效果。我们通过频繁参与UTMB广泛的地区母婴健康计划(RMCHP)，成功地招募和留住了患者。RMCHP的所有诊所都遵循母胎医学部制定的方案，病人在加尔维斯顿的UTMB接生。UTMB服务的两个县--加尔维斯顿和布拉索里亚--的孕妇将构成基于地理的人口。其中90%以上的患者在UTMB诊所接受治疗，并在John Sealy医院分娩。如果需要，这一目标人群可以适当地扩展到基于邮政编码或县的其他RMCHP诊所。此外，该部的电子医疗记录记录了在线输入的产前和产中信息，可供授权调查人员随时查询。以同样的方式，我们部门的组织库为临床研究增加了广泛的效率。PI和Co-I、医学博士Radec Bukowski之间出色而富有成效的合作为StillBirth网络提供了进一步的好处。此外，我们系的遗传学顾问珍妮弗·李将担任我们网站的外展工作人员，她作为一名成熟的悲痛顾问带来了丰富的经验。我们部拥有一支富有成效且资金雄厚的基础科学研究小组，他们在许多与RFA相关的领域拥有专业知识，如感染、血管生理学、胎盘功能和胎儿发育。最后，我们与我们大学的病理学系以及遗传学和新生儿学部建立了良好的合作关系(见支持函)。特别是，UTMB有一个备受推崇的围产期病理学部门，在本RFA感兴趣的各个领域拥有专业知识，包括神经病理学和胎盘病理学。根据我们目前对DNA微阵列技术的兴趣，我们提出的研究概念是确定死胎特有的单核苷酸多态(SNP)标记谱。我们接受RFA的强制和参与性规定，并随时准备成为NIH静产网络的贡献者。

DESCRIPTION (provided by applicant): The University of Texas Medical Branch at Galveston (UTMB) has the capability to participate actively as a member of the NIH multisite Stillbirth Network. PI George R. Saade, MD, offers extensive experience within several NIH multisite clinical trials og: First and Second Trimester Evaluation of Risk of Aneuploidy (FASTER); First Trimester Nuchal Translucency and the Risk of Congenital Heart Disease; Twin-Twin Transfusion Syndrome Trial; and Beneficial Effects of Antenatal Magnesium Sulfate Study (BEAM). We have achieved successful patient recruitment and retention by frequent involvement with UTMB's extensive Regional Maternal & Child Health Program (RMCHP). All of RMCHP's clinics follow protocols established by the Maternal-Fetal Medicine division, and the patients are delivered at UTMB in Galveston. Pregnant women in two counties served by UTMB--Galveston and Brazoria--will constitute the geographic-based population. More than 90% of these patients are cared for at a UTMB clinic and deliver at John Sealy Hospital. If needed, this target population can be expanded to other RMCHP clinics based on zip codes or counties, as appropriate. Further, the Department's Electronic Medical Record captures antepartum and intrapartum information, entered on-line, that is readily available for query by authorized investigators. In like manner, our Department's Tissue Bank has added broad efficiencies to clinical investigation. The excellent and productive collaboration between PI and Co-I, Radec Bukowski, MD, PhD, offers further benefits to the Stillbirth Network. In addition, our Department's genetics counselor, Jennifer Lee, who will serve as our site's outreach worker, brings considerable experience as an established grief counselor. Our Department has a very productive and well-funded basic science research group with expertise in many areas of relevance to the RFA, such as infection, vascular physiology, placental function, and fetal growth. Finally, we have well-established collaborative ties with our University's Department of Pathology and divisions of Genetics and Neonatology (see letters of support). In particular, UTMB has a highly regarded Perinatal Pathology division with expertise in various areas of interest to this RFA, including neuropathology and placental pathology. Following on our current interest in DNA microarray technology, our proposed study concept is to determine a single nucleotide polymorphism (SNP) marker profile particular to stillbirth. We accept the capitation and participatory stipulations of this RFA and stand ready to become a contributinq member of the NIH Stillbirth Network.