Molecular Epidemiology in Children's Environmental Health Training Program

儿童环境健康分子流行病学培训项目

• 批准号: 8078499
• 负责人: Ranjan Deka
• 金额: $ 35.89万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078499
• 关键词: Child; Environmental Health; Molecular Epidemiology; Training Programs; health training

DESCRIPTION (provided by applicant) The Molecular Epidemiology in Children's Environmental Health (MECEH) training program began July, 2001 and is in its tenth training year. MECEH is defined as the use of biological, molecular and statistical measures in epidemiological research to determine how environmental exposures impact children's health at the physiologic, behavioral, cellular, and molecular levels. As the offspring of epidemiology, medicine, statistical genetics, molecular biology, and molecular genetics, molecular epidemiology serves as an umbrella for focused research in genetic and biomarker epidemiology. MECEH has 3 participating departments: Environmental Health, Pediatric Medicine and Molecular Genetics. MECEH has had continuous full enrollment with 13 pre-doctoral and 24 postdoctoral fellows trained or in training, including 19 M.D./D.O fellows, one DDS, and one environmental engineer. Trainees have made great professional strides with national presentations, numerous publications, grant submissions and obtaining academic research positions. This application requests support for four pre-doctoral and six postdoctoral positions each year for 2011-2016, which will maintain this program at its current size. The MECEH's long term objective is to continue increasing the number of cross-trained epidemiologists, physician epidemiologists and molecular biologists who investigate high impact issues related to environmental exposures and complex childhood diseases. The overarching rationale for this training program has been stated in such federal initiatives as the Children's Health Act of 2000 (H.R.4365) which stressed "investment in tomorrow's pediatric researchers" (sec 1002). The MECEH has 3 primary goals: 1) provide a strong grounding in epidemiologic, statistical and wet and dry laboratory molecular methods, 2) prepare students for interdisciplinary research training and "enhance clinical research workforce training" as stated in the NIH roadmap, and 3) in concert with Francis Collins' direction for opportunities and challenges the investigators seek to expand growth areas for trainee expertise in statistical genomics, epigenetic epidemiology, and design of community based participatory research. These goals are achieved through the recruitment of high quality applicants, including underrepresented minorities, mentorship by a core of world-renowned teacher-scientists, support by research-intensive environmental health, pediatric and molecular genetics departments, well-funded scientific programs and Centers, and advice from an enthusiastic External Advisory Board. The public health significance of the MECEH program is directly correlated to the increasing national awareness of the rising number of environmentally related disease such as diabetes, obesity, asthma, neurodevelopmental disorders, and prematurity, among others. Thus, the public health relevance of the program is great, and is directly related to the need for researchers knowledgeable across disciplines in cutting-edge methodologies in the area of pediatric environmental health.

描述（由申请人提供） 儿童环境卫生分子流行病学（MECEH）培训计划于2001年7月开始，目前已进入第十个培训年。 MECEH被定义为在流行病学研究中使用生物、分子和统计措施，以确定环境暴露如何在生理、行为、细胞和分子水平上影响儿童健康。作为流行病学、医学、统计遗传学、分子生物学和分子遗传学的产物，分子流行病学是遗传学和生物标志物流行病学的重点研究领域。 MECEH有3个参与部门：环境卫生，儿科医学和分子遗传学。 MECEH已连续招收了13名博士前和24名博士后研究员，其中包括19名M.D./ D.O研究员，一名DDS，一名环境工程师。受训人员在国家演讲、众多出版物、赠款提交和获得学术研究职位方面取得了巨大的专业进步。该申请要求在2011-2016年每年支持四个博士前和六个博士后职位，这将使该计划保持目前的规模。 MECEH的长期目标是继续增加交叉培训的流行病学家，医生流行病学家和分子生物学家的数量，他们调查与环境暴露和复杂儿童疾病有关的高影响问题。这项培训计划的总体原理已在联邦倡议中阐明，如2000年儿童健康法（H.R.4365），强调“投资于明天的儿科研究人员”（第1002节）。MECEH有三个主要目标：1）提供流行病学，统计学和干湿实验室分子方法的坚实基础，2）为学生进行跨学科研究培训和“加强临床研究队伍培训”做好准备，如NIH路线图所述，和3）与弗朗西斯柯林斯的机遇和挑战方向一致，调查人员寻求扩大统计专业培训生的增长领域基因组学、表观遗传流行病学和基于社区的参与性研究设计。这些目标是通过招募高质量的申请人，包括代表性不足的少数民族，由世界知名的教师科学家的核心指导，研究密集型环境卫生，儿科和分子遗传学部门，资金充足的科学计划和中心的支持，以及来自热情的外部咨询委员会的建议。 MECEH计划的公共卫生意义与国民对糖尿病、肥胖症、哮喘、神经发育障碍和早产等环境相关疾病数量不断增加的认识直接相关。因此，该计划的公共卫生相关性很大，并且与对儿科环境健康领域前沿方法学跨学科知识的研究人员的需求直接相关。