Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)

项目摘要/摘要 儿童环境健康分子流行病学(MECEH)培训计划于2001年7月开始 目前已进入第20个培训年。MECEH的定义是使用生物学、分子和生物统计学 流行病学研究中确定环境暴露如何影响儿童健康的措施 生理、行为、细胞和分子水平。流行病学、医学、统计学的结合 遗传学、分子生物学、分子遗传学和分子流行病学是 重点研究环境流行病学、生物标志物和遗传学。MECEH有四个参与者 系/专业：环境与公共卫生科学、儿科学、精神病学和行为学 神经科学和辛辛那提医学科学家培训计划。MECEH已经有了连续的满 招收27名博士后研究员和53名博士后研究员，其中包括39名医学博士/博士研究生。实习生已经取得了 在国家报告、大量出版物、拨款申请和获得 学术、政府和工业研究职位。此应用程序请求支持4名博士后 2022-2027年每年6个博士后职位，以保持目前的规模。 MECEH培训方案的长期目标是继续增加交叉培训的人数 流行病学家、内科科学家、生物统计学家和研究高影响的分子生物学家 与环境暴露和复杂的儿童疾病有关的问题。这样做的主要理由是 方案是，分子流行病学的培训不仅对我们理解复杂的起源至关重要 通过提供关于影响风险的特定机制、分子和基因的线索 为新一代儿科研究人员提供跨学科培训的框架 工作。因此，MECEH培训方案有三个主要目标：1)为 流行病学、生物统计学和分子方法；2)为学生进行跨学科研究和 “加强临床研究人员培训”，如美国国立卫生研究院路线图所述；3)扩大增长领域 表观基因组学/‘基因组学’和基于社区的参与性研究的流行病学培训；以及4)提供 职业发展规划，以促进职业成功和可持续性。这些目标都实现了 通过招聘高素质的申请者，包括代表性不足的少数群体、领导层和 以国内和国际知名科学家为核心的导师，以研究密集型为支持 部门；资金充足的科学计划和中心；以及来自杰出和热情的建议 外部咨询委员会。

PROJECT SUMMARY / ABSTRACT The Molecular Epidemiology in Children’s Environmental Health (MECEH) Training Program began July, 2001 and is in its 20th training year. MECEH is defined as the use of biological, molecular and biostatistical measures in epidemiological research to determine how environmental exposures impact children’s health at the physiologic, behavioral, cellular, and molecular levels. The marriage of epidemiology, medicine, statistical genetics, molecular biology, molecular genetics, and molecular epidemiology serves as an umbrella for focused research in environmental epidemiology, biomarkers and genetics. MECEH has four participating departments/programs: Environmental and Public Health Sciences, Pediatrics, psychiatry and behavioral neuroscience, and the Cincinnati Medical Scientist Training Program. MECEH has had a continuous full enrollment with 27 Predoctoral and 53 Postdoctoral Fellows, including 39 MD/DO fellows. Trainees have made great professional strides with national presentations, numerous publications, grant submissions and obtaining academic, government and industrial research positions. This application requests support for 4 predoctoral and 6 postdoctoral positions each year for 2022-2027, to maintain its current size. The MECEH Training Program’s long-term objective is to continue to increase the number of cross-trained epidemiologists, physician-scientists, biostatisticians, and molecular biologists who investigate high impact issues related to environmental exposures and complex childhood diseases. The overarching rationale for this program is that training in molecular epidemiology is not only vital to our understanding of the origin of complex disease by providing clues regarding specific mechanisms, molecules and genes that influence risk but also provides a framework for interdisciplinary training for a new generation of pediatric researchers to perform this work. Thus, the MECEH Training Program has three primary goals: 1) provide a strong grounding in epidemiologic, biostatistical, and molecular methods; 2) prepare students for interdisciplinary research and “enhance clinical research workforce training,” as stated in the NIH roadmap; 3) expand growth areas for epidemiological training in epigenomics/’omics’ and community based participatory research; and 4) provide career development programming to promote career success and sustainability. These goals are achieved through the recruitment of high quality applicants, including underrepresented minorities, leadership and mentorship by a core of nationally- and internationally- renowned scientists, support by research-intensive departments; well-funded scientific programs and centers; and advise from a distinguished and enthusiastic External Advisory Board.