Immunopathological role of monocyte-macrophages in flavivirus encephalitis.

单核细胞-巨噬细胞在黄病毒脑炎中的免疫病理学作用。

• 批准号: nhmrc : 512413
• 负责人: Prof Iain Campbell
• 金额: $ 29.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immunopathological-role-monocyte-flavivirus-encephalitis/95518
• 关键词: Immunopathological; role; monocyte; macrophages; flavivirus

Viral encephalitis is a life-threatening infection of the brain for which there are no reliable treatments. White cells called monocytes enter the brain from the blood and although important in the immune response that destroys the virus, can also damage the brain. Our work focuses on determining how monocytes migrate into the brain in viral infection, what functions they have once inside the brain, and how to exclude a certain types of monocytes that we have found to be particularly damaging.

病毒性脑炎是一种危及生命的脑部感染，目前尚无可靠的治疗方法。被称为单核细胞的白细胞从血液中进入大脑，虽然在破坏病毒的免疫反应中很重要，但也会损害大脑。我们的工作重点是确定单核细胞如何在病毒感染中迁移到大脑中，它们一旦进入大脑具有什么功能，以及如何排除我们发现特别具有破坏性的某些类型的单核细胞。