The regulation and function of strawberry notch in neuroinflammation

草莓切迹在神经炎症中的调控及作用

• 批准号: nhmrc : 1047265
• 负责人: Prof Iain Campbell
• 金额: $ 48.92万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-function-strawberry-notch-neuroinflammation/111924
• 关键词: regulation; function; strawberry; notch; neuroinflammation

Inflammation is a response to injury and infection that may cause significant damage to the brain. This project will study the regulation and function of a novel gene called strawberry notch that we have identified is a major target of the protein IL-6 which is a central mediator of inflammation in the brain. The findings will advance our understanding of the function of Sbno2 in the context of the actions of IL-6 and will provide crucial new mechanistic insights into a cause of neurological disease.

炎症是对损伤和感染的反应，可能会对大脑造成重大损害。该项目将研究一种名为草莓切口的新基因的调节和功能，我们已经确定该基因是蛋白质IL-6的主要靶点，而IL-6是大脑中炎症的中心介质。这些发现将促进我们对Sbno 2在IL-6作用背景下的功能的理解，并将为神经系统疾病的原因提供重要的新机制见解。