Interleukin-6 -gp130 signaling and actions in the CNS

CNS 中的 Interleukin-6 -gp130 信号传导和作用

• 批准号: nhmrc : 632754
• 负责人: Prof Iain Campbell
• 金额: $ 36.61万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interleukin-6-gp130-actions-cns/99899
• 关键词: Interleukin; gp130; signaling; actions; CNS

Interleukin-6 (IL-6) is a member of a family of cytokine proteins that may be causative factors in many neurological disorders where they are involved in diverse processes including inflammation, neuronal injury and repair. In this project we will study how IL-6 affects the brain to bring about these outcomes. The results of this work will advance our understanding of how members of this cytokine family function and how they contribute to neurological disease.

白介素6(IL-6)是细胞因子蛋白家族中的一员，可能是许多神经系统疾病的致病因子，参与多种过程，包括炎症、神经元损伤和修复。在这个项目中，我们将研究IL-6如何影响大脑来实现这些结果。这项工作的结果将促进我们对这一细胞因子家族成员如何发挥作用以及它们如何导致神经疾病的理解。