The role of ghrelin and NPY signaling in the regulation of energy homeostasis

ghrelin 和 NPY 信号在能量稳态调节中的作用

• 批准号: 8129579
• 负责人: Heather Dungan Lemko
• 金额: $ 4.97万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129579
• 关键词: Acute; Body Weight; Cardiovascular Diseases; Cells; Chronic; Diabetes Mellitus; Diet; Eating; Energy Metabolism; Fatty acid glycerol esters; Glucose; Homeostasis; Hormones; Hyperglycemia; Hyperphagia; Insulin Resistance; Knockout Mice; Link; Mediating; Obesity; Overnutrition; Predisposition; Receptor Signaling; Regulation; Role; Signal Transduction; Somatotropin; Weight Gain; Work; blood glucose regulation; feeding; ghrelin; ghrelin receptor; global health; insulin sensitivity; receptor expression; research study; respiratory; restoration

DESCRIPTION (provided by applicant): Obesity has become a global health concern because it is linked to such conditions as cardiovascular disease, diabetes, respiratory illness, and others. The work described in this proposal will "contribute to our understanding of the mechanisms underlying obesity and insulin resistance by examining how the pro-obesity hormone ghrelin triggers overeating, weight gain, and hyperglycemia."

描述（由申请人提供）： 肥胖已经成为一个全球性的健康问题，因为它与心血管疾病有关， 疾病、糖尿病、呼吸系统疾病等。本提案中描述的工作将“通过研究促肥胖激素胃饥饿素如何引发暴饮暴食、体重增加和高血糖，有助于我们了解肥胖和胰岛素抵抗的潜在机制。"

项目成果

Kiss of the mutant mouse: how genetically altered mice advanced our understanding of kisspeptin's role in reproductive physiology.

突变小鼠之吻：基因改造小鼠如何增进我们对 Kisspeptin 在生殖生理学中作用的理解。

• DOI: 10.1210/en.2012-1494
• 发表时间: 2012
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: DunganLemko,HeatherM;Elias,CarolF
• 通讯作者: Elias,CarolF