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Role of Central Vasopressin/ERK Signaling in Ethanol Dependence

Role of Central Vasopressin/ERK Signaling in Ethanol Dependence
中枢加压素/ERK 信号在乙醇依赖中的作用
批准号：
8123465
负责人：
Scott Edwards
金额：
$1.33万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-13 至 2011-07-12
来源：
https://reporter.nih.gov/project-details/8123465
关键词：
AirAlcohol consumptionAlcohol dependenceAlcohol withdrawal syndromeAlcoholismAlcoholsAmygdaloid structureAnimal BehaviorAnimal ModelAnimalsAnti-Anxiety AgentsAntidepressive AgentsAnxietyArgipressinBehaviorCRF receptor type 1Cell NucleusChronicCorticotropin-Releasing HormoneDevelopmentDrug AddictionEffectivenessEthanolEthanol dependenceExposure toExtracellular Signal Regulated KinasesHeavy DrinkingHormonalIn VitroIndividualInvestigationLeadMEKsMeasuresMediatingMental DepressionMicroinjectionsMolecularMolecular Mechanisms of ActionMotivationNegative ReinforcementsNeuronsNeuropeptidesPeptidesPharmaceutical PreparationsPhosphorylationReceptor SignalingRegulationRelapseResearchRoleSSR149415Self AdministrationSignal PathwaySignal TransductionStressSymptomsSystemTestingTimeU-0126V1b vasopressin receptorVasopressinsWithdrawalWithdrawal SymptomWorkalcohol testingaversive conditioningbasebiological adaptation to stressdrinkingeffective therapyhypothalamic-pituitary-adrenal axisin vivoinhibitor/antagonistinsightneuromechanismnext generationpublic health relevancereceptorsmall moleculevapor

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英文摘要
DESCRIPTION (provided by applicant): The applicant did not provide a description. PUBLIC HEALTH RELEVANCE: Although most people are capable of limiting alcohol use for recreational purposes, others tend to drink in an excessive and uncontrolled fashion. In addition, these individuals often drink to alleviate aversive conditions associated with alcohol withdrawal (such as anxiety or depression), and are therefore described as being dependent on alcohol. This research aims to understand the neural mechanisms of alcohol dependence and to facilitate the development of new medications that target excessive drinking in dependent individuals.
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  • 批准号：
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  • 项目类别：
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  • 依托单位：
    LSU HEALTH SCIENCES CENTER
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