Role of Central Vasopressin/ERK Signaling in Ethanol Dependence

中枢加压素/ERK 信号在乙醇依赖中的作用

• 批准号: 8123465
• 负责人: Scott Edwards
• 金额: $ 1.33万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-13 至 2011-07-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8123465
• 关键词: Air; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholism; Alcohols; Amygdaloid structure; Animal Behavior; Animal Model; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Argipressin; Behavior; CRF receptor type 1; Cell Nucleus; Chronic; Corticotropin-Releasing Hormone; Development; Drug Addiction; Effectiveness; Ethanol; Ethanol dependence; Exposure to; Extracellular Signal Regulated Kinases; Heavy Drinking; Hormonal; In Vitro; Individual; Investigation; Lead; MEKs; Measures; Mediating; Mental Depression; Microinjections; Molecular; Molecular Mechanisms of Action; Motivation; Negative Reinforcements; Neurons; Neuropeptides; Peptides; Pharmaceutical Preparations; Phosphorylation; Receptor Signaling; Regulation; Relapse; Research; Role; SSR149415; Self Administration; Signal Pathway; Signal Transduction; Stress; Symptoms; System; Testing; Time; U-0126; V1b vasopressin receptor; Vasopressins; Withdrawal; Withdrawal Symptom; Work; alcohol testing; aversive conditioning; base; biological adaptation to stress; drinking; effective therapy; hypothalamic-pituitary-adrenal axis; in vivo; inhibitor/antagonist; insight; neuromechanism; next generation; public health relevance; receptor; small molecule; vapor

DESCRIPTION (provided by applicant): The applicant did not provide a description. PUBLIC HEALTH RELEVANCE: Although most people are capable of limiting alcohol use for recreational purposes, others tend to drink in an excessive and uncontrolled fashion. In addition, these individuals often drink to alleviate aversive conditions associated with alcohol withdrawal (such as anxiety or depression), and are therefore described as being dependent on alcohol. This research aims to understand the neural mechanisms of alcohol dependence and to facilitate the development of new medications that target excessive drinking in dependent individuals.

描述（由申请人提供）：申请人未提供描述。 公共卫生相关性：虽然大多数人都能够限制酒精的使用，以娱乐为目的，其他人倾向于过度饮酒和不受控制的方式。此外，这些人经常喝酒以减轻与酒精戒断相关的厌恶性状况（如焦虑或抑郁），因此被描述为依赖酒精。这项研究旨在了解酒精依赖的神经机制，并促进开发针对依赖者过度饮酒的新药物。