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Role of Central Vasopressin/ERK Signaling in Ethanol Dependence

Role of Central Vasopressin/ERK Signaling in Ethanol Dependence
中枢加压素/ERK 信号在乙醇依赖中的作用
批准号：
7943923
负责人：
Scott Edwards
金额：
$5.01万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-13 至 2011-07-12
来源：
https://reporter.nih.gov/project-details/7943923
关键词：
AirAlcohol consumptionAlcohol dependenceAlcohol withdrawal syndromeAlcoholismAlcoholsAmygdaloid structureAnimal BehaviorAnimal ModelAnimalsAnti-Anxiety AgentsAntidepressive AgentsAnxietyArgipressinBehaviorCRF receptor type 1Cell NucleusChronicCorticotropin-Releasing HormoneDevelopmentDrug AddictionEffectivenessEthanolEthanol dependenceExposure toExtracellular Signal Regulated KinasesHeavy DrinkingHormonalIn VitroIndividualInvestigationLeadMEKsMeasuresMediatingMental DepressionMicroinjectionsMolecularMolecular Mechanisms of ActionMotivationNegative ReinforcementsNeuronsNeuropeptidesPeptidesPharmaceutical PreparationsPhosphorylationReceptor SignalingRegulationRelapseResearchRoleSSR149415Self AdministrationSignal PathwaySignal TransductionStressSymptomsSystemTestingTimeU-0126V1b vasopressin receptorVasopressinsWithdrawalWithdrawal SymptomWorkalcohol testingaversive conditioningbasebiological adaptation to stressdrinkingeffective therapyhypothalamic-pituitary-adrenal axisin vivoinhibitor/antagonistinsightneuromechanismnext generationpublic health relevancereceptorsmall moleculevapor

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中文摘要
翻译
描述（由申请人提供）：申请人未提供描述。 公共卫生相关性：虽然大多数人都能够限制酒精的使用，以娱乐为目的，其他人倾向于过度饮酒和不受控制的方式。此外，这些人经常喝酒以减轻与酒精戒断相关的厌恶性状况（如焦虑或抑郁），因此被描述为依赖酒精。这项研究旨在了解酒精依赖的神经机制，并促进开发针对依赖者过度饮酒的新药物。
英文摘要
DESCRIPTION (provided by applicant): The applicant did not provide a description. PUBLIC HEALTH RELEVANCE: Although most people are capable of limiting alcohol use for recreational purposes, others tend to drink in an excessive and uncontrolled fashion. In addition, these individuals often drink to alleviate aversive conditions associated with alcohol withdrawal (such as anxiety or depression), and are therefore described as being dependent on alcohol. This research aims to understand the neural mechanisms of alcohol dependence and to facilitate the development of new medications that target excessive drinking in dependent individuals.
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