Patient Oriented Research in Gastrointestinal Cancer Screening

描述(由申请者提供)：这个K24职业中期研究员奖将帮助培训参加GI流行病学专门培训计划(T32-DK062708)的GI研究员，指导申请/完成职业发展奖的初级教师，以及在由NIH和VA资助的GI癌症筛查试验中以患者为导向的研究的表现。“对未来成功的最好预测可能是过去的成就。”作为密歇根大学胃肠道流行病学培训计划的首席研究员和主任，我成功地指导了100%的参与者在学术医学方面的职业生涯。在我们的项目中，GI研究员完成临床研究设计和统计分析的硕士项目，并接受高级研究人员的广泛指导和监督，这有助于他们成功过渡到学术医学。在初级教员完成这个培训计划后，我还会指导他们获得K23、R21和其他职业发展奖励。除了为指导学员和初级教师提供受保护的时间外，这笔赠款还将促进我的研究职业目标：识别GI癌症的风险因素，并开发更有效的GI癌症筛查工具。我已经成功地完成了K23和R21的资助，这导致了多本出版物的出版。目前，我是退伍军人事务部资助的一个中心基金的PI，该基金致力于应用家族病史和基因组工具来改进结直肠癌(CRC)筛查，并与人共同研究U54基金，开发体内生物标记物，用于在内窥镜检查中识别食道和结肠的异型增生。这些正在进行的研究项目将为学员和初级教员提供一个平台，让他们发展自己的研究。此外，密歇根大学提供了出色的环境和资源，包括我们的GI流行病学专业培训计划、NIH资助的密歇根临床研究单位、VA资助的实践管理和结果研究卓越中心，以及我们公共卫生学院的临床流行病学专业硕士课程。不幸的是，对GI研究员和初级教员的指导没有资金。目前的U54和VA资金用于支付研究用品、设备和辅助人员的费用，但提供的资金不足，无法保护我用于以患者为导向的研究和指导的时间。这个K24奖项将为实现我的导师和研究目标提供必要的支持。 公共卫生相关性：该奖项将为指导年轻研究人员进行以患者为导向的胃肠道癌症筛查研究提供支持。它还将为完成这一主题的研究提供候选人。拟议的研究将改进Barrett‘s食道癌和食管腺癌的筛查技术，促进对有结直肠癌家族史的患者进行适当筛查，确定结肠腺瘤的可改变的风险因素，并确定新的工具来检测胃肠道异型增生。

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award will facilitate training GI fellows participating in a specialized Training Program in GI Epidemiology (T32-DK062708), mentoring of junior faculty applying for/completing career development awards, and performance of patient-oriented research in GI cancer screening trials funded by NIH and VA. "The best predictor of future success may be past achievement." As principal investigator and Director of the U. of Michigan Training Program in GI Epidemiology, I have successfully mentored 100% of the participants to careers in academic medicine. In our program, GI fellows complete a Master's program in Clinical Research Design and Statistical Analysis and undergo extensive mentoring and supervision from senior investigators which contributes to their successful transition to academic medicine. I also mentor junior faculty on K23, R21, and other career development awards after they complete this training program. In addition to providing protected time to mentor trainees and junior faculty, this grant will also facilitate my research career objective: identification of risk factors for GI cancer and development of more effective tools for GI cancer screening. I have successfully completed K23 and R21 grants which have led to multiple publications. Currently, I am PI of a VA-funded Center grant about the application of family history and genomic tools to improve colorectal cancer (CRC) screening, and co-investigator of a U54 grant developing in vivo biomarkers for the identification of dysplasia in the esophagus and colon during endoscopy. These on-going research projects will provide a platform for trainees and junior faculty to develop their own research. Also, the U. of Michigan provides an outstanding environment and resources, including our specialized Training Program in GI Epidemiology, our NIH-funded Michigan Clinical Research Unit, VA-funded Center of Excellence for Practice Management and Outcomes Research, and our School of Public Health's specialized Master's Programs in Clinical Epidemiology. Unfortunately, mentoring of GI fellows and junior faculty is unfunded. The current U54 and VA funding pay for research supplies, equipment, and ancillary personnel, but provides inadequate funding to protect my time for patient-oriented research and mentorship. This K24 award will provide essential support to achieve my mentorship and research goals. PUBLIC HEALTH RELEVANCE: This award will provide support to mentor young investigators performing patient-oriented GI cancer screening research. It will also provide the candidate to complete studies on this topic. The proposed studies will improve screening techniques for Barrett's esophagus and esophageal adenocarcinoma, facilitate appropriate screening of patients with a family history of colorectal cancer, identify modifiable risk factors for colon adenomas, and identify new tools to detect dysplasia in the gastrointestinal tract.